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General Information
Symbol
Dmel\ptcG20
Species
D. melanogaster
Name
FlyBase ID
FBal0032507
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of 66bp in the 5' region of the coding sequence that eliminates 22 amino acids. At the 3' end of the deletion five new bases are present introducing two new amino acids just before the last amino acids of exon 1. Deletion of 66bp in the 5' region of the coding region eliminating 22 amino acids and an insertion of 5 bases at the 3' end of the deletion introducing two new amino acids.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ptcG20/ptc16 wing discs show an extension of all sensory organ precursor cells close to the A/P border, with extra sensilla induced in the Sc25, Sc4d and Sc12 clusters and extra vein 3 sensilla throughout the anterior compartment.

ptc4/ptcG20 flies have very abnormal legs, showing overgrowth, excess bristles, truncations and segments of abnormal length.

ptcG20/ptc16 heterozygotes display severe disorganisation and necrosis of the wing.

The combination ptcG20/ptc9 is pupal lethal but ptcG20/ptc16 is semi-viable. ptcG20/ptc16 wings show overgrowth of the anterior compartment, partial or complete loss of vein 2 and plexation of veins 1 and 3. Extra bristles appear on the notum and there are morphological alterations in the legs.

ptc4/ptcG20 transheterozygotes partially or totally lack triple-row bristles.

Additional bristles in second leg.

In ptcG20 homozygotes the shape of the wing and vein pattern are altered. Vein 2 is partially or completely deleted and veins 1 and 3 are broadened and/or plexate. ptcG20 in combination with lethal ptc alleles may cause more loss of bristles in the costa.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

ptcG20 has visible phenotype, suppressible by kn1

ptcG20 has visible phenotype, suppressible by knKN4

Phenotype Manifest In
Suppressed by
Statement
Reference

ptcG20 has wing vein L2 phenotype, suppressible by kn1

ptcG20 has wing vein L2 phenotype, suppressible by knKN4

ptc16/ptcG20 has phenotype, suppressible by fuJ

ptcG20/ptc4 has phenotype, suppressible by fuJ

ptc16/ptcG20 has phenotype, suppressible | partially by dppd5/dppd12

Additional Comments
Genetic Interactions
Statement
Reference

Loss of wing vein L2 is suppressed by kn1 and knKN4.

fuJ; ptcG20/ptc16 or fuJ; ptcG20/ptc4 flies are viable and show a fu phenotype, and the ptc phenotype is rescued, although occasionally incompletely.

Partial rescue of the ptc phenotype is seen in dppd12 ptcG20 / dppd5 ptc16, increased bristle numbers on legs, antennae and notum are lower and reduced overgrowth of pharate adult legs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

lethality seen in combination with ptc16 can be rescued by the ptchs.PSa. ptchs.PSa partially rescues the lethality and wing and wing venation defects seen in combination with ptc9.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
ptcG20
Name Synonyms
Secondary FlyBase IDs
    References (15)