FlyBase Allele Report: Dmel\ptc[G20]

General Information

Symbol

Dmel\ptc^G20

Species

D. melanogaster

Name

FlyBase ID

FBal0032507

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Mullor and Guerrero, 2000)

loss of function allele

(Nestoras et al., 1997)

Mutagen

gamma ray

(Phillips et al., 1990)

Progenitor genotype

Cytology

Description

Deletion of 66bp in the 5' region of the coding sequence that eliminates 22 amino acids. At the 3' end of the deletion five new bases are present introducing two new amino acids just before the last amino acids of exon 1. Deletion of 66bp in the 5' region of the coding region eliminating 22 amino acids and an insertion of 5 bases at the 3' end of the deletion introducing two new amino acids.

(Capdevila et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Mullor and Guerrero, 2000, Nestoras et al., 1997, Capdevila et al., 1994, Phillips et al., 1990)

visible

(Nestoras et al., 1997)

visible | recessive

(Sanchez-Herrero et al., 1996, Held, 1993)

Phenotype Manifest In

campaniform sensillum of dorsal radius Sc4d | precursor

(Mullor et al., 1997)

campaniform sensillum of dorsal radius Sc12 | precursor

(Mullor et al., 1997)

campaniform sensillum of dorsal radius Sc25 | precursor

(Mullor et al., 1997)

costal wing cell

(Capdevila et al., 1994)

leg

(Sanchez-Herrero et al., 1996, Capdevila et al., 1994)

macrochaeta

(Sanchez-Herrero et al., 1996, Capdevila et al., 1994)

mesothoracic tarsal bristle longitudinal row 5

(Held, 1993)

mesothoracic tarsal bristle longitudinal row 5.5

(Held, 1993)

mesothoracic tarsal bristle longitudinal row 7

(Held, 1993)

scutellar bristle

(Capdevila et al., 1994)

sensory mother cell

(Mullor et al., 1997)

wing blade anterior compartment

(Capdevila et al., 1994)

wing disc anterior compartment

(Mullor et al., 1997)

wing vein

(Capdevila et al., 1994)

wing vein L2

(Nestoras et al., 1997)

Detailed Description

Statement

Reference

ptc^G20/ptc¹⁶ wing discs show an extension of all sensory organ precursor cells close to the A/P border, with extra sensilla induced in the Sc25, Sc4d and Sc12 clusters and extra vein 3 sensilla throughout the anterior compartment.

(Mullor et al., 1997)

ptc⁴/ptc^G20 flies have very abnormal legs, showing overgrowth, excess bristles, truncations and segments of abnormal length.

(Sanchez-Herrero et al., 1996)

ptc^G20/ptc¹⁶ heterozygotes display severe disorganisation and necrosis of the wing.

(Capdevila and Guerrero, 1994)

The combination ptc^G20/ptc⁹ is pupal lethal but ptc^G20/ptc¹⁶ is semi-viable. ptc^G20/ptc¹⁶ wings show overgrowth of the anterior compartment, partial or complete loss of vein 2 and plexation of veins 1 and 3. Extra bristles appear on the notum and there are morphological alterations in the legs.

(Capdevila et al., 1994)

ptc⁴/ptc^G20 transheterozygotes partially or totally lack triple-row bristles.

(Hidalgo, 1994)

Additional bristles in second leg.

(Held, 1993)

In ptc^G20 homozygotes the shape of the wing and vein pattern are altered. Vein 2 is partially or completely deleted and veins 1 and 3 are broadened and/or plexate. ptc^G20 in combination with lethal ptc alleles may cause more loss of bristles in the costa.

(Phillips et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ptc^G20 has visible phenotype, suppressible by kn¹

(Nestoras et al., 1997)

ptc^G20 has visible phenotype, suppressible by kn^KN4

(Nestoras et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

ptc^G20 has wing vein L2 phenotype, suppressible by kn¹

(Nestoras et al., 1997)

ptc^G20 has wing vein L2 phenotype, suppressible by kn^KN4

(Nestoras et al., 1997)

ptc¹⁶/ptc^G20 has phenotype, suppressible by fu^J

(Sanchez-Herrero et al., 1996)

ptc^G20/ptc⁴ has phenotype, suppressible by fu^J

(Sanchez-Herrero et al., 1996)

ptc¹⁶/ptc^G20 has phenotype, suppressible | partially by dpp^d5/dpp^d12

(Capdevila et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Loss of wing vein L2 is suppressed by kn¹ and kn^KN4.

(Nestoras et al., 1997)

fu^J; ptc^G20/ptc¹⁶ or fu^J; ptc^G20/ptc⁴ flies are viable and show a fu phenotype, and the ptc phenotype is rescued, although occasionally incompletely.

(Sanchez-Herrero et al., 1996)

Partial rescue of the ptc phenotype is seen in dpp^d12 ptc^G20 / dpp^d5 ptc¹⁶, increased bristle numbers on legs, antennae and notum are lower and reduced overgrowth of pharate adult legs.

(Capdevila et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ptc^G20 is rescued by ptc^hs.PSa

(Capdevila et al., 1994)

Comments

lethality seen in combination with ptc¹⁶ can be rescued by the ptc^hs.PSa. ptc^hs.PSa partially rescues the lethality and wing and wing venation defects seen in combination with ptc⁹.

(Capdevila et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ptc^G20

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

Open Close