FlyBase Allele Report: Dmel\ptc[4]

General Information

Symbol

Dmel\ptc⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0028494

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

Also Known As

ptc^6P, ptc^6P43

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Capdevila et al., 1994, Hooper, 1994)

loss of function allele

(Strigini and Cohen, 1997)

Mutagen

ethyl methanesulfonate

(Hidalgo and Ingham, 1990, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Bejsovec and Wieschaus, 1993)

some die during embryonic stage | recessive

(Bejsovec and Wieschaus, 1993)

visible | recessive

(Sanchez-Herrero et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

100% of ptc^hdl/ptc⁴ transheterozygotes show head capsule defects.

(Shyamala and Bhat, 2002)

ptc⁴/ptc^G20 flies have very abnormal legs, showing overgrowth, excess bristles, truncations and segments of abnormal length.

(Sanchez-Herrero et al., 1996)

Homozygous mutant clones present in the anterior compartment of the male foreleg cause bifurcation.

(Lepage et al., 1995)

Clonal analysis of cells lacking ptc demonstrates that lack of ptc function is able to de-repress the dpp gene.

(Capdevila et al., 1994)

ptc⁴/ptc^G20 transheterozygotes partially or totally lack triple-row bristles.

(Hidalgo, 1994)

No reduction in rate of germ band extension, in wg, ptc, en triple mutants.

(Irvine and Wieschaus, 1994)

Mutant embryos have abnormal naked cuticle and row-1 and row-2-type ventral denticles.

(Bejsovec and Wieschaus, 1993)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

ptc^G20/ptc⁴ has phenotype, suppressible by fu^J

(Sanchez-Herrero et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

fu^J; ptc^G20/ptc⁴ flies are viable and show a fu phenotype, and the ptc phenotype is rescued, although occasionally incompletely.

(Sanchez-Herrero et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ptc^k02507

(Prokopenko et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

ptc⁴

ptc^6P43

(Shyamala and Bhat, 2002, Von Ohlen and Hooper, 1997, Hooper, 1994, Irvine and Wieschaus, 1994, Bejsovec and Wieschaus, 1993, Hidalgo and Ingham, 1990)

ptc^6P

(Denef et al., 2000, Strigini and Cohen, 1997, Sanchez-Herrero et al., 1996, Lepage et al., 1995, Ma and Moses, 1995, Capdevila et al., 1994, Hidalgo, 1994, Tearle and Nusslein-Volhard, 1987)

ptc^6p43

(DiNardo et al., 1988)

ptc^6p

(Huang and Kunes, 1998)

tuf⁴

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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