DiNardo, S., Sher, E., Heemskerk-Jongens, J., Kassis, J.A., O'Farrell, P.H. (1988). Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 332(): 604--609.
FlyBase ID
FBrf0048767
Publication Type
Research paper
Abstract
A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory genes, for example the pair-rule genes, are expressed transiently and as their products decay a distinct regulatory programme involving segment polarity genes takes over. This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication.
