FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hh3
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General Information
Symbol
Dmel\hh3
Species
D. melanogaster
Name
FlyBase ID
FBal0005464
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
Also Known As
hh6N16, hh6N
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Mohler, 1988)

loss of function allele

(McDonald and Doe, 1997)
Mutagen
ethyl methanesulfonate
(Mohler, 1988, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In hh3 mutants, midline cells do not differentiate and instead die during late embryogenesis.

      (Bossing and Brand, 2006)

      Mutant embryos have exclusively row-5-type denticles arranged in a disorganized pattern of ventral midline whorls, with no naked cuticle.

      (Bejsovec and Wieschaus, 1993)

      40% length of wild type larvae and exhibit a ventral lawn of denticles associated with the loss of naked cuticle from the ventral surface. No obvious segmentation.

      (Mohler, 1988)

      Deletion of naked cuticle and fusion of denticle bands.

      (Carroll and Scott, 1986)

      Strong phenotype. Mutant embryos show no obvious segmentation, and are 40% the length of wild type; denticles form a lawn arranged in a number of whorls on the ventral surface as a result of loss of naked cuticle.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      hh3 is a non-enhancer of eye phenotype of Nspl-1

      (Nagel and Preiss, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Has no effect on the eye phenotype of Nspl-1.

      (Nagel and Preiss, 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series in terms of phenotype severity: hh3 > hh8 > hh4.

      (Glazer and Shilo, 2001)

      Strong allele of hh.

      (Mohler, 1988)

      Mutations in hh enhance the wg phenotype.

      (Bejsovec and Wieschaus, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (14)