FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ptck02507
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General Information
Symbol
Dmel\ptck02507
Species
D. melanogaster
Name
FlyBase ID
FBal0044325
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
P{lacW}ptck02507
Carried in Construct
Also Known As
l(2)k02507, Ptc-LacZ, k02507
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kania et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}ptck02507
Cytology
Description

P{lacW} insertion in the first intron of ptc.

(Prokopenko et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF175904
AF175905
AF175906
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes show a direct effect on the shape of the wing, with a widening of the central region of the wing relative to other landmarks in the wing.

      (Dworkin and Gibson, 2006)

      Homozygous embryos exhibit defects in the location and organisation of most clusters, in addition to a loss of neurons in the dorsal cluster. Embryos also exhibit severe pathfinding defects as well as gaps in the CNS.

      (Kania et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      Comments
      Comments

      Complements: Rho1k02107b. Complements: Vps25k08904. Complements: l(2)44DEak16116. Complements: l(2)s1878s1878.

      (BDGP Project Members, 1994-1999)

      P{lacW} insertion can be excised and revert the lethal phenotype to wild type.

      (Kania et al., 1995)
      External Crossreferences and Linkouts ( 3 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      25/7
      (Kania et al., 1995)
      k02507
      (Dworkin et al., 2011, Dworkin and Gibson, 2006)
      l(2)k02507
      (Dockendorff et al., 2000, Prokopenko et al., 2000, Spradling et al., 1999)
      ptck02507
      ptck02527
      (Akimoto et al., 2005)
      rubrk02507
      (BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)