FlyBase Allele Report: Dmel\ptc[10]

General Information

Symbol

Dmel\ptc¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0028500

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

Also Known As

ptc^B98, ptc^IIB

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Phillips et al., 1990)

some die during embryonic stage

(Phillips et al., 1990)

visible, with Scer\GAL4^T80, ptc^Δ1.2C.UAS

(Lu et al., 2006)

Phenotype Manifest In

adult head capsule (with ptc^hdl)

(Shyamala and Bhat, 2002)

double row of wing sensilla, with Scer\GAL4^71B, ptc^1130X.UAS

(Johnson et al., 2000)

first basal wing cell, with Scer\GAL4^71B, ptc^D584N.UAS

(Johnson et al., 2002)

first posterior wing cell, with Scer\GAL4^71B, ptc^D584N.UAS

(Johnson et al., 2002)

wing blade anterior compartment, with Scer\GAL4^T80, ptc^Δ1.2C.UAS

(Lu et al., 2006)

wing vein, with Scer\GAL4^T80, ptc^Δ1.2C.UAS

(Lu et al., 2006)

wing vein | ectopic, with Scer\GAL4^71B, ptc^1130X.UAS

(Johnson et al., 2000)

wing vein | ectopic, with Scer\GAL4^71B, ptc^D584N.UAS

(Johnson et al., 2002)

wing vein L3, with Scer\GAL4^71B, ptc^1130X.UAS

(Johnson et al., 2000)

wing vein L4, with Scer\GAL4^71B, ptc^1130X.UAS

(Johnson et al., 2000)

Detailed Description

Statement

Reference

Expression of ptc^{Δ1.2C.Scer\UAS} under the control of Scer\GAL4^T80 in ptc¹⁰/+ flies results in wings with enlarged anterior compartments and extensive vein defects.

(Lu et al., 2006)

100% of ptc^hdl/ptc¹⁰ transheterozygotes show head capsule defects.

(Shyamala and Bhat, 2002)

The addition of heterozygous ptc¹⁰ enhances the wing phenotypes seen in ptc^{1130X.Scer\UAS}, Scer\GAL4^71B flies alone. There is increased venation in the vein 3 region and a larger row of bristles at the wing margin.

(Johnson et al., 2000)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ptc[+]/ptc¹⁰ is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

ptc[+]/ptc¹⁰ is a suppressor of wing vein phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ptc^k02507

(Prokopenko et al., 2000)

Rescued by

ptc¹⁶/ptc¹⁰ is rescued by Scer\GAL4^ptc-559.1/ptc^Y442C.UAS

(Johnson et al., 2002)

Partially rescued by

ptc¹⁰ is partially rescued by ptc^UAS.cJa/Scer\GAL4^hs.PB

(Lu et al., 2006)

Not rescued by

ptc¹⁰ is not rescued by ptc^Δ1.2C.UAS/Scer\GAL4^hs.PB

(Lu et al., 2006)

ptc¹⁶/ptc¹⁰ is not rescued by Scer\GAL4^ptc-559.1/ptc^D584N.UAS

(Johnson et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

IIB98

ptc¹⁰

(Casso et al., 2008)

ptc^B98

(Biehs et al., 2010, Lu et al., 2006, Johnson et al., 2002, Ramirez-Weber et al., 2001, Johnson et al., 2000)

ptc^B

(Ramirez-Weber et al., 2001)

ptc^IIB98

(Shyamala and Bhat, 2002)

ptc^IIB

(Ma and Moses, 1995, Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)

tuf¹⁰

Name Synonyms

Secondary FlyBase IDs

FBal0123747

References (12)

Report Sections

Open Close