FlyBase Allele Report: Dmel\Snoo[GS-C517T]

General Information

Symbol

Dmel\Snoo^GS-C517T

Species

D. melanogaster

Name

FlyBase ID

FBal0196806

Feature type

allele

Associated gene

Dmel\Snoo

Associated Insertion(s)

P{GSV6}GS18054

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ramel et al., 2007)

Progenitor genotype

P{GSV6}GS18054

(Ramel et al., 2007)

Associated Insertion(s)

P{GSV6}GS18054

Cytology

Description

Nucleotide substitution: C517T.

(Ramel et al., 2007)

The P{GSV6}Snoo^GS18054 insertion present on the progenitor chromosome is still present.

(Ramel et al., 2007)

Amino acid replacement: ?173term.

(Ramel et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:7,975,674..7,975,674 [-]

Nucleotide change:

C7975674T

Reported nucleotide change:

C517T

Amino acid change:

Q173term | Snoo-PB; Q173term | Snoo-PC; Q173term | Snoo-PD; Q173term | Snoo-PG

Reported amino acid change:

Q173term

(Ramel et al., 2007)

transposable_element_insertion_site

2L:7,976,904..7,976,904

(Ramel et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-fertile

(Ramel et al., 2007)

viable

(Ramel et al., 2007)

viable, with Scer\GAL4^Act.PU

(Ramel et al., 2007)

viable, with Scer\GAL4^Tub.PU

(Ramel et al., 2007)

visible, with Scer\GAL4^Act.PU

(Ramel et al., 2007)

visible, with Scer\GAL4^Tub.PU

(Ramel et al., 2007)

visible | dominant

(Ramel et al., 2007)

Phenotype Manifest In

wing vein | ectopic

(Ramel et al., 2007)

wing vein | ectopic, with Scer\GAL4^Act.PU

(Ramel et al., 2007)

wing vein | ectopic, with Scer\GAL4^Tub.PU

(Ramel et al., 2007)

Detailed Description

Statement

Reference

Homozygotes and heterozygotes have no significant growth defects, either in whole animals or in individual structures such as the wing and eye.

93.8% of homozygotes have ectopic vein tissue in thw wing, occasionally around vein L2, but more consistently in the vicinity of the posterior crossvein and wing vein L5. Ectopic veins located posterior to L5 have a dorsal identity, while ectopic veins protruding from the posterior crossvein and anterior to L5 mostly have a ventral identity.

Approximately 20% of heterozygotes have an ectopic wing vein phenotype (the precise frequency depends on genetic background).

Flies expressing Snoo^GS-C517T under the control of Scer\GAL4^ap-md544 do not show an upturned wing phenotype.

Flies expressing Snoo^GS-C517T under the control of Scer\GAL4^Act or Scer\GAL4^tub have multiple ectopic wing veins in the L5 region.

(Ramel et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, Snoo^GS-C517T has visible phenotype, suppressible | partially by dpp^d5/dpp[+]

(Ramel et al., 2007)

Scer\GAL4^Tub.PU, Snoo^GS-C517T has visible phenotype, suppressible | partially by dpp^d6/dpp[+]

(Ramel et al., 2007)

Scer\GAL4^Tub.PU, Snoo^GS-C517T has visible phenotype, suppressible | partially by dpp^s11/dpp[+]

(Ramel et al., 2007)

Snoo^GS-C517T has visible phenotype, suppressible by dpp^d5/dpp[+]

(Ramel et al., 2007)

Snoo^GS-C517T has visible phenotype, suppressible by dpp^d6/dpp[+]

(Ramel et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, Snoo^GS-C517T has wing vein | ectopic phenotype, suppressible | partially by dpp^d5/dpp[+]

(Ramel et al., 2007)

Scer\GAL4^Tub.PU, Snoo^GS-C517T has wing vein | ectopic phenotype, suppressible | partially by dpp^d6/dpp[+]

(Ramel et al., 2007)

Scer\GAL4^Tub.PU, Snoo^GS-C517T has wing vein | ectopic phenotype, suppressible | partially by dpp^s11/dpp[+]

(Ramel et al., 2007)

Snoo^GS-C517T has wing vein | ectopic phenotype, suppressible by dpp^d5/dpp[+]

(Ramel et al., 2007)

Snoo^GS-C517T has wing vein | ectopic phenotype, suppressible by dpp^d6/dpp[+]

(Ramel et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the Snoo^GS-C517T/Snoo^GS-C517T ectopic wing vein phenotype is significantly suppressed if the flies are also carrying one copy of dpp^d5 or dpp^d6.

The frequency of the ectopic wing vein phenotype caused by expression of Snoo^GS-C517T under the control of Scer\GAL4^tub is significantly suppressed if the flies are also carrying one copy of dpp^d5, dpp^d6 or dpp^s11.

(Ramel et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Snoo^GS-C517T is partially rescued by Snoo^UAS.cRa/Scer\GAL4^bs-1348

(Ramel et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a revertant of the upturned wing phenotype caused by expression of Snoo^GS18054 under the control of Scer\GAL4^Bx-MS1096.

(Ramel et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Snoo^GS-C517T

dSno^GS-C517T

(Ramel et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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