FlyBase Allele Report: Dmel\dpp[s11]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\dpp^s11

General Information

Symbol

Dmel\dpp^s11

Species

D. melanogaster

Name

FlyBase ID

FBal0003081

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

S11

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

(Segal and Gelbart, 1985)

Progenitor genotype

Caused by aberration

Cytology

Description

Breakpoint allele.

(St. Johnston et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(St. Johnston et al., 1990, Segal and Gelbart, 1985)

lethal - all die before end of larval stage (with dpp^s3)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s5)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s12)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s13)

(Stultz et al., 2005)

lethal - all die before end of P-stage

(Stultz et al., 2005)

lethal - all die before end of P-stage (with dpp^s20)

(Stultz et al., 2005)

lethal - all die before end of P-stage (with dpp^s22)

(Stultz et al., 2005)

lethal - all die before end of pupal stage

(Huang et al., 2011)

some die during larval stage (with dpp^s3)

(Stultz et al., 2005)

some die during larval stage (with dpp^s5)

(Stultz et al., 2005)

some die during larval stage (with dpp^s12)

(Stultz et al., 2005)

some die during larval stage (with dpp^s13)

(Stultz et al., 2005)

some die during pharate adult stage

(Stultz et al., 2005)

some die during pharate adult stage (with dpp^s20)

(Stultz et al., 2005)

some die during pharate adult stage (with dpp^s22)

(Stultz et al., 2005)

viable (with dpp^s6)

(Stultz et al., 2005)

viable (with dpp^s7)

(Stultz et al., 2005)

viable (with dpp^s-hc1)

(Stultz et al., 2005)

(Stultz et al., 2005)

visible (with dpp^s3)

(Stultz et al., 2005)

visible (with dpp^s4)

(Ray and Wharton, 2001)

visible (with dpp^s5)

(Stultz et al., 2005)

visible (with dpp^s6)

(Stultz et al., 2005)

visible (with dpp^s7)

(Stultz et al., 2005)

visible (with dpp^s12)

(Stultz et al., 2005)

visible (with dpp^s13)

(Stultz et al., 2005)

visible (with dpp^s20)

(Stultz et al., 2005)

visible (with dpp^s22)

(Stultz et al., 2005)

visible (with dpp^s-hc1)

(Stultz et al., 2005)

visible (with dpp^TgR46.1)

(Stultz et al., 2005)

visible | dominant

(Segal and Gelbart, 1985)

Phenotype Manifest In

adult head capsule

(Stultz et al., 2005)

adult head capsule (with dpp^s3)

(Stultz et al., 2005)

adult head capsule (with dpp^s5)

(Stultz et al., 2005)

adult head capsule (with dpp^s7)

(Stultz et al., 2005)

adult head capsule (with dpp^s12)

(Stultz et al., 2005)

adult head capsule (with dpp^s13)

(Stultz et al., 2005)

adult head capsule (with dpp^s20)

(Stultz et al., 2005)

adult head capsule (with dpp^s22)

(Stultz et al., 2005)

adult head capsule (with dpp^s-hc1)

(Stultz et al., 2005)

adult head capsule (with dpp^TgR46.1)

(Stultz et al., 2005)

embryonic/larval midgut

(Masucci and Hoffmann, 1993)

(Masucci and Hoffmann, 1993)

(St. Johnston et al., 1990)

posterior crossvein

(Stultz et al., 2005)

posterior crossvein (with dpp^s4)

(Ray and Wharton, 2001)

vibrissal bristle

(St. Johnston et al., 1990)

wing (with dpp^s3)

(Stultz et al., 2005)

wing (with dpp^s5)

(Stultz et al., 2005)

wing (with dpp^s7)

(Stultz et al., 2005)

wing (with dpp^s12)

(Stultz et al., 2005)

wing (with dpp^s13)

(Stultz et al., 2005)

wing (with dpp^s20)

(Stultz et al., 2005)

wing (with dpp^s22)

(Stultz et al., 2005)

(Stultz et al., 2005, St. Johnston et al., 1990)

wing vein L2 | distal (with dpp^s4)

(Ray and Wharton, 2001)

wing vein L4 | distal (with dpp^s4)

(Ray and Wharton, 2001)

wing vein L5 | distal (with dpp^s4)

(Ray and Wharton, 2001)

Detailed Description

Statement

Reference

Heterozygotes do not have an ectopic wing vein phenotype.

(Ramel et al., 2007)

20% of homozygotes show pharate adult lethality and the remaining 80% develop as adults with head capsule and wing vein defects.

50% of dpp^s22/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 50% die as pharate adults.

Some dpp^s20/dpp^s11 animals develop as adults with head capsule and wing defects, while others die as pharate adults.

42% of dpp^s3/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 58% die as larvae.

27% of dpp^s12/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 73% die as larvae.

45% of dpp^s5/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 55% die as larvae.

60% of dpp^s13/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 40% die as larvae.

dpp^s7/dpp^s11 animals have head capsule and wing defects.

(Stultz et al., 2005)

dpp^s4/dpp^s11 flies have a "shortvein" phenotype; the distal ends of L2, L4 and L5 are truncated. The posterior crossvein is missing.

(Ray and Wharton, 2001)

dpp expression in shv-class of dpp alleles has been examined: they selectively remove aspects of embryonic visceral mesoderm expression of dpp.

(Hursh et al., 1993)

Midguts from dpp^s11/dpp^s22 mutant larvae exhibit variable gastric caeca length and/or absence defects.

(Masucci and Hoffmann, 1993)

Weak pharate adult lethal when heterozygous with other dpp alleles. Adult escapers display wing venation defects, reduced maxillary palps and vibrissae head capsule.

(St. Johnston et al., 1990)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dpp^s11 has increased mortality during development phenotype, suppressible | partially by jhamt^UAS.cUa/Scer\GAL4^Aug21

(Huang et al., 2011)

Enhancer of

Statement

Reference

dpp^s11 is an enhancer of visible phenotype of Art1⁵⁰

(Brückner, 2013.7.16)

Suppressor of

Statement

Reference

dpp^s11/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^s11 is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

dpp^s11/dpp[+] is a suppressor of wing vein | ectopic phenotype of MAN1^ΔC

(Wagner et al., 2010)

dpp^s11/dpp[+] is a suppressor of posterior crossvein phenotype of MAN1^ΔC

(Wagner et al., 2010)

dpp^s11/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^s11 is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

Art1⁵⁰/Art1[+], dpp^s11 has wing vein phenotype

(Brückner, 2013.7.16)

Additional Comments

Genetic Interactions

Statement

Reference

Combining heterozygous Art1⁵⁰ with homozygous dpp^s11 results in the shortening of the fifth longitudinal vein L5 in almost all flies, a venation defect that is not seen in homozygous Art1⁵⁰ or Art1⁵⁰ heterozygotes alone.

(Brückner, 2013.7.16)

Only 14% of MAN1^ΔC flies heterozygous for dpp^s11 show extra venation.

(Wagner et al., 2010)

The frequency of the ectopic wing vein phenotype caused by expression of Snoo^GS-C517T under the control of Scer\GAL4^tub is significantly suppressed if the flies are also carrying one copy of dpp^s11.

(Ramel et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

dpp^H46/dpp^s11 is partially rescued by dpp^Sal20

(Stultz et al., 2005)

Df(2L)DTD2/dpp^s11 is partially rescued by dpp^Sal20

(Stultz et al., 2005)

Comments

Belongs to the shv-p class of alleles.

(St. Johnston et al., 1990)

Allele class: shv-p

Images (0)

Mutant

Wild-type

Stocks (2)

2065

106646

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

S11

(Brugger et al., 2004)

dpp^S11

(Wagner et al., 2010, Ramel et al., 2007, Bach et al., 2003)

dpp^s11

(Li et al., 2020, Brückner, 2013.7.16, Matsuda et al., 2013, Matsuda and Shimmi, 2012, Huang et al., 2011, Stultz et al., 2006)

s11

(Stultz et al., 2005)

shv^S11

(Segal and Gelbart, 1985)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections