FlyBase Allele Report: Dmel\dpp[s12]

General Information

Symbol

Dmel\dpp^s12

Species

D. melanogaster

Name

FlyBase ID

FBal0003082

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Segal and Gelbart, 1985)

Progenitor genotype

Caused by aberration

In(2L)dpp^s12

Cytology

Description

Deletion of promoters P4 and P5.

(Panganiban et al., 1990)

Breakpoint allele.

(St. Johnston et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | larval stage (with dpp^s22)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s22)

(Stultz et al., 2005)

lethal | recessive

(Segal and Gelbart, 1985)

lethal - all die before end of larval stage

(St. Johnston et al., 1990)

lethal - all die before end of larval stage (with dpp^s3)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s5)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s7)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s11)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s13)

(Stultz et al., 2005)

lethal - all die before end of larval stage (with dpp^s20)

(Stultz et al., 2005)

lethal - all die before end of larval stage | recessive

(Masucci and Hoffmann, 1993)

some die during larval stage

(St. Johnston et al., 1990)

some die during larval stage (with dpp^s3)

(Stultz et al., 2005)

some die during larval stage (with dpp^s5)

(Stultz et al., 2005)

some die during larval stage (with dpp^s7)

(Stultz et al., 2005)

some die during larval stage (with dpp^s11)

(Stultz et al., 2005)

some die during larval stage (with dpp^s13)

(Stultz et al., 2005)

some die during larval stage (with dpp^s20)

(Stultz et al., 2005)

some die during larval stage | recessive

(Masucci and Hoffmann, 1993)

viable (with dpp^s6)

(Stultz et al., 2005)

visible (with dpp^s6)

(Stultz et al., 2005)

visible (with dpp^s11)

(Stultz et al., 2005)

visible | dominant

(Segal and Gelbart, 1985)

Phenotype Manifest In

adult head capsule (with dpp^s11)

(Stultz et al., 2005)

embryonic/larval midgut

(Masucci and Hoffmann, 1993)

gastric caecum

(Masucci and Hoffmann, 1993)

wing (with dpp^s11)

(Stultz et al., 2005)

Detailed Description

Statement

Reference

Adult dpp^s12/dpp^s22 escapers have wing and head capsule defects.

27% of dpp^s12/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 73% die as larvae.

(Stultz et al., 2005)

Defects in second midgut section and gastric caecae. Four day old mutant larvae remain in the first and second instars.

(Masucci and Hoffmann, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

FoxK⁴⁴, dpp^s12 has lethal phenotype

(Casas-Tinto et al., 2008)

FoxK¹⁶, dpp^s12 has lethal phenotype

(Casas-Tinto et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygous dpp^s12; fd68A¹⁶ mutants exhibit almost 100% lethality.

Double heterozygous dpp^s12; fd68A⁴⁴ mutants exhibit almost 100% lethality.

(Casas-Tinto et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^s4/dpp^s12 is rescued by dpp^dpp.674

(Capovilla et al., 1994)

dpp^s12 is rescued by dpp^{7175-8391.lacZ}

(Masucci and Hoffmann, 1993)

Partially rescued by

dpp^s12 is partially rescued by dpp^7191.lacZ

(Masucci and Hoffmann, 1993)

Not rescued by

dpp^s12 is not rescued by dpp^8391.lacZ

(Masucci and Hoffmann, 1993)

Comments

dpp^dpp.674 completely rescues the second midgut constriction phenotype of dpp^s4/dpp^s12 mutant embryos.

(Capovilla et al., 1994)

Complements all disk region mutants. Belongs to the shv-lc class of alleles.

(St. Johnston et al., 1990)

Allele class: shv-lc

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dpp^S12

(Casas-Tinto et al., 2008, Panganiban et al., 1990)

dpp^s12

(Casas-Tinto et al., 2008)

s12

(Stultz et al., 2005)

shv^S12

(Segal and Gelbart, 1985)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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