FlyBase Allele Report: Dmel\dpp[s6]

General Information

Symbol

Dmel\dpp^s6

Species

D. melanogaster

Name

FlyBase ID

FBal0003076

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Segal and Gelbart, 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Segal and Gelbart, 1985)

Description

Deletion of 4845bp, including the 812bp regulatory region that directs expression in parasegment 7 of the visceral mesoderm.

(Sun et al., 1995)

Deletion within shv region.

(St. Johnston et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Segal and Gelbart, 1985)

viable

(Stultz et al., 2005)

viable (with dpp^s3)

(Stultz et al., 2005)

viable (with dpp^s5)

(Stultz et al., 2005)

viable (with dpp^s7)

(Stultz et al., 2005)

viable (with dpp^s11)

(Stultz et al., 2005)

viable (with dpp^s12)

(Stultz et al., 2005)

viable (with dpp^s20)

(Stultz et al., 2005)

viable (with dpp^s22)

(Stultz et al., 2005)

visible

(Stultz et al., 2005)

visible (with dpp^s3)

(Stultz et al., 2005)

visible (with dpp^s5)

(Stultz et al., 2005)

visible (with dpp^s7)

(Stultz et al., 2005)

visible (with dpp^s11)

(Stultz et al., 2005)

visible (with dpp^s12)

(Stultz et al., 2005)

visible (with dpp^s20)

(Stultz et al., 2005)

visible (with dpp^s22)

(Stultz et al., 2005)

visible | dominant

(Segal and Gelbart, 1985)

Phenotype Manifest In

Detailed Description

Statement

Reference

wing

(with dpp[s11]) wing

(with dpp[s22]) wing

(with dpp[s20]) wing

(with dpp[s7]) wing

(with dpp[s3]) wing

(with dpp[s12]) wing

(with dpp[s5]) wing

(Stultz et al., 2005)

dpp^s6/dpp^hr4 transheterozygotes are adult viable and exhibit occasional wing vein defects. Truncation of longitudinal vein 5 (L5) is observed in approximately 11% of adults, while 2% display truncations of L4 and L5.

(Takaesu et al., 2005)

dpp^hr4/dpp^s6 causes relatively few wings to have abnormal venation.

(Nicholls and Gelbart, 1998)

Abnormal gut morphology.

(Hursh et al., 1993)

Fails to form second midgut constriction. Length of midgut reduced in section 2, with remaining cells having hexagonal shape. Small but statistically significant decrease in the viability of adults.

(Masucci and Hoffmann, 1993)

Affect adult wing venation.

(St. Johnston et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Mad¹, dpp^s6/dpp^hr4 has lethal phenotype

(Takaesu et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Mad¹

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L5 phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L4 phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L5 phenotype, enhanceable by Df(2L)C28/+

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L4 phenotype, enhanceable by Df(2L)C28/+

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L5 phenotype, enhanceable by Df(3R)E40/+

(Takaesu et al., 2005)

dpp^s6 has wing vein phenotype, enhanceable by Df(2R)Pcl11B/+

(Nicholls and Gelbart, 1998)

dpp^s6 has wing vein phenotype, enhanceable by Df(2R)Pcl7B/+

(Nicholls and Gelbart, 1998)

Other

Statement

Reference

Df(2L)C28/+, dpp^s6/dpp^hr4 has wing vein L2 phenotype

(Takaesu et al., 2005)

Df(2L)C28/+, dpp^s6/dpp^hr4 has posterior crossvein phenotype

(Takaesu et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

dpp^s6/dpp^hr4 Mad¹ flies exhibit L4 and L5 wing vein defects in almost 100% of cases. Approximately 10% of wings with L4 and L5 defects exhibit missing crossveins (anterior, posterior, or both) and small wing margin notches. This indicates an enhancement of the dpp^s6/dpp^hr4 phenotype by Mad¹.

Only 71% of the expected dpp^s6/dpp^hr4 Mad¹ progeny are recovered, indicating a statistically significant amount of lethality.

dpp^s6/dpp^hr4 Med⁷ flies exhibit L4 and L5 wing vein defects in approximately 42% of cases, with 15% of these wings also exhibiting defects in L2, or the posterior crossvein or margin notches.

(Takaesu et al., 2005)

The incidence of abnormal venation in dpp^hr4/dpp^s6 is increased by Df(2R)Pcl11B or Df(2R)Pcl7B.

(Nicholls and Gelbart, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^s6/dpp^H46 is rescued by dpp^Sal20

(Stultz et al., 2005)

Df(2L)DTD2/dpp^s6 is rescued by dpp^Sal20

(Stultz et al., 2005)

Not rescued by

dpp^s6/dpp^H46 is not rescued by dpp^P15

(Stultz et al., 2005)

Comments

dpp^s-hc1 and dpp^TgR46.1 each fully complement the wing vein defects of dpp^s6.

(Stultz et al., 2005)

Allele class: shv-w

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81063

y¹ w^*; ast¹ dpp^s6 ed¹ dpy^ov1 cl¹/SM6a

Notes on Origin

Discoverer

Comments

Used to examine regulation of dpp-Ecol\lacZ promoter fusions, whose expression depends on endogenous dpp function demonstrating that positiveautoregulation maintains dpp expression in the visceral mesoderm.

(Hursh et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dpp^s6

(Quijano et al., 2011, Takaesu et al., 2005, Grienenberger et al., 2003)

dpp^shv6

(Graba et al., 1995)

(Stultz et al., 2005)

shv^S6

(Segal and Gelbart, 1985)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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