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General Information
Symbol
Dmel\Ubx130
Species
D. melanogaster
Name
FlyBase ID
FBal0017400
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The anterior compartment is increased in size in Ubx130/Ubxbx-3 haltere discs.

The posterior compartment is increased in size in Ubx130/Ubxpbx-1 haltere discs.

Ubx130 heterozygotes display slightly enlarged halteres compared to wild-type.

In Ubx130 mutant adults, halters are homogeneous in size and shape, being slightly larger than those in wild-type.

Ubx130 heterozygotes have normal halteres and nota.

Like Ubx1 as a dominant. RK1A.

Increases the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

Flies carrying both RpII215Ubl and Ubx130 show a greater transformation of haltere to wing than flies carrying RpII215Ubl alone.

Transheterozygotes with UbxS1, UbxS2 and UbxS3 are viable.

T(2;3)T1-19/Ubx130 flies show reduced viability and fecundity.

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is increased in flies also containing a copy of Ubx130.

Heterozygotes have a slight transformation of haltere to wing at 29oC and 17oC. Ubx130/UbxCbx-1 flies show a temperature sensitive phenotype; flies grown at 29oC have a slight conversion of haltere to wing and strong transformation of wing to haltere, while those grown at 17oC have a strong haltere to wing transformation and a slight transformation of wing to haltere. The UbxCbx-1 transformation in the wing is generally reduced and the Ubx130 transformation in the haltere is generally enhanced in the transheterozygote, compared to heterozygous or homozygous UbxCbx-1 or Ubx130 flies respectively.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

TrlR85, Ubx130, Ubx[+], Ubx+ has homeotic phenotype, enhanceable by Taf3Fa4a

TrlR85, Ubx130 has visible phenotype, enhanceable by pho1

Trl[+]/TrlR85, Ubx130 has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18

TrlR85, Ubx130, Ubx[+], Ubx+ has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18

Suppressor of
Statement
Reference

Ubx130/Ubx[+] is a suppressor | partially of visible phenotype of dppd5/dppd12

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

TrlR85, Ubx130, Ubx[+], Ubx+ has haltere phenotype, enhanceable by Taf3Fa4a

TrlR85, Ubx130, Ubx[+], Ubx+ has wing | ectopic phenotype, enhanceable by Taf3Fa4a

Ubx130 has haltere phenotype, enhanceable by Df(3L)Aprt-21

Trl13C, Ubx130 has haltere phenotype, enhanceable by Df(3L)Aprt-21

Ubx130 has haltere phenotype, enhanceable by Trl13C

Trl[+]/TrlR85, Ubx130 has haltere phenotype, enhanceable by +/Df(2R)Δ18

TrlR85, Ubx130, Ubx[+], Ubx+ has haltere phenotype, enhanceable by +/Df(2R)Δ18

TrlR85, Ubx130, Ubx[+], Ubx+ has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18

Trl[+]/TrlR85, Ubx130 has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18

Ubx130 has phenotype, enhanceable by Trl13C

Suppressed by
Suppressor of
Statement
Reference

Ubx130/Ubx[+] is a suppressor | partially of capitellum phenotype of dppd5/dppd12

Other
Additional Comments
Genetic Interactions
Statement
Reference

Ubx130 Ino80Δ4 double heterozygotes have a haltere to wing transformation with 100% penetrance.

2.48% of flies carrying one copy of TrlR85 and one copy of Ubx130 show a mild haltere to wing transformation.

Homozygous bip2Fa4a does not enhance the frequency of haltere to wing transformation seen in TrlR85/TM2, Ubx130 flies (2.73% of flies show transformations, compared to 2.48%), but it does enhance the severity of the transformation.

The reduced size of the capitellum seen in dppd5/dppd12 adults is partially suppressed by Ubx130/+.

TrlR85/Ubx130; pho1 flies show an enhancement of the Ubx130 phenotype in 18% of flies.

Double heterozygous lolalk02512 Ubx130 flies do not show significant increase in the expressivity of the Ubx phenotype. lolalk02512/+; Trl13C/Ubx130 flies display a higher frequency (18%) of strong haltere-to-wing transformations compared to Trl13C/Ubx130 siblings (6.3%). This increased transformation is often accompanied by a notal transformation.

56% of Ubx130, Trl13C double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone. 63% of Ubx130, Df(3L)Aprt-21 double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone. 78% of Ubx130, Df(3L)Aprt-21, Trl13C triple heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone, also exhibiting a stronger phenotype than any two of the alleles used. The haltere becomes a wing -like structure with wing veins and hairs on the wing margin.

Ubx130/TrlR85 flies have a low penetrance of haltere to wing transformations and notal transformations. The penetrance of these phenotypes is significantly enhanced by heterozygosity for Df(2R)Δ18, even though the phenotypes are present at a very low penetrance (<0.5%) in Ubx130, Df(2R)Δ18 double heterozygotes.

Flies doubly heterozygous for Ubx130 and Trl13C show larger halteres than Ubx130 heterozygotes alone, and with variable penetrance and expressivity show homeotic transformations of the haltere and postnotum. When zae(bx) is added to the doubly heterozygous combination the Ubx phenotype is enhanced.

Heterozygotes have slightly enlarged halteres compared to wild type. Trl13C+/+Ubx130 double heterozygous flies have larger halteres than Ubx130 heterozygotes. Homeotic transformations include a low frequency of patches on the haltere and postnotum that develop like wing and notum tissues respectively.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (17)
Notes on Origin
Discoverer
Comments
Comments

Temperature-shift experiments show that the temperature sensitive period in Ubx130/UbxCbx-1 flies extends throughout embryonic and larval life.

The brm2 or trxE2 mutations greatly increase the frequency of haltere to wing transformation in double heterozygotes with Ubx130.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (33)