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Citation
Farkas, G., Gausz, J., Galloni, M., Reuter, G., Gyurkovics, H., Karch, F. (1994). The Trithorax-like gene encodes the Drosophila GAGA factor.  Nature 371(6500): 806--808.
FlyBase ID
FBrf0076985
Publication Type
Research paper
Abstract

Little is known about the way higher-order chromatin structure influences gene expression and chromosome topology in general. Genetic analysis in Drosophila has led to the discovery of two classes of genes, the regulators of homeotic genes and the modifiers of position-effect variegation, which seem to be good candidates for encoding some of the factors regulating chromatin functions. The Trithorax-like gene we described here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation. We found that Trithorax-like encodes the GAGA factor which is involved in the formation of an accessible chromatin structure at promoter sequences. Our genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (2)
    Alleles (5)
    Genes (6)
    Insertions (1)