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General Information
Symbol
Dmel\Trl62
Species
D. melanogaster
Name
FlyBase ID
FBal0029713
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Transposable element inserted 5' of the transcription start site.

Insertion components
P{hsneo.ry+}Trl62
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Trl13C/Trl62 females have a similar viability to homozygotes, males show a significantly reduced viability.

Most homozygotes die as third instar larvae.

Lethality occurs at metamorphosis.

brm2 shows little if any interaction in double heterozygous combination with Trl62; less than 3% of flies have held-out wings.

Enhances the position effect variegation at the w locus caused by In(1)wm4 and enhances the position effect variegation at the bw locus caused by In(2R)bwVDe2. Does not enhance position effect variegation at the bw locus caused by Byron or the position effect variegation of w seen in the P{wAR}41A insertion.

Transheterozygotes with Trl13C are even less viable than Trl13C homozygotes.

Moderate enhancer of position effect variegation. Heterozygotes with Trl13C eclose late, are poorly viable and exhibit the same phenotypes as Trl13C homozygotes.

Enhances variegation of In(1)wm4h.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Trl62/Trl13C has lethal | male phenotype, enhanceable by msl-2[+]/msl-21

Trl62/Trl13C has lethal | male phenotype, enhanceable by msl-11/msl-1[+]/msl-2[+]/msl-21/mle1/mle[+]

Trl62/Trl13C has lethal | male phenotype, enhanceable by msl-11/msl-1[+]

NOT Enhanced by
Statement
Reference

Trl62/Trl13C has partially lethal | female phenotype, non-enhanceable by msl-11/msl-1[+]/msl-2[+]/msl-21/mle1/mle[+]

Trl62/Trl13C has partially lethal | female phenotype, non-enhanceable by msl-11/msl-1[+]

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

Trl62/Trl13C has partially lethal | female phenotype, non-suppressible by msl-11/msl-1[+]

Trl62/Trl13C has partially lethal | female phenotype, non-suppressible by mle1/mle[+]

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Trl[+]/Trl62 is an enhancer of sex comb | ectopic & mesothoracic leg phenotype of Pc3

Trl62 is an enhancer of mesothoracic leg phenotype of Pc3

Trl[+]/Trl62 is an enhancer of sex comb | ectopic & mesothoracic leg phenotype of Pc15

Trl62 is an enhancer of mesothoracic leg phenotype of Pc15

Suppressor of
Statement
Reference

Trl62 is a suppressor | partially of eye phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference

Mutant weakly suppresses the CycEJP rough eye phenotype.

Mutant heterozygotes show a weak enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes.

The frequency of homeotic transformations seen in heterozygotes is increased in double heterozygous combination with mod(mdg4)ul or mod(mdg4)T16. Dominantly enhances the effect of mod(mdg4)ul on the y2 phenotype.

The formation of extra sex combs on the second and third legs in Pc4/+ flies is not enhanced by Trl62.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Trl62.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Weak enhancer. High spontaneous background rate of E(var) mutations in these experiments allows for the possibility that the P insertion is not the cause of the E(var) phenotype.

Attempts to make germ-line clones with this allele failed.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (20)