FlyBase Allele Report: Dmel\Antp[73b]

General Information

Symbol

Dmel\Antp^73b

Species

D. melanogaster

Name

FlyBase ID

FBal0000573

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Doc{}Antp^73b

Carried in Construct

Also Known As

Antp⁷³

Key Links

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Bhojwani et al., 1997, Adamson and Shearn, 1996, Jorgensen and Garber, 1987)

Mutagen

spontaneous

(Hazelrigg and Kaufman, 1983, Scott et al., 1983, Kaufman et al., 1980)

recombination

(Schneuwly et al., 1987)

Progenitor genotype

Doc{}sas^Doc

(Schneuwly et al., 1987)

Doc{}Antp^Doc

(Schneuwly et al., 1987)

Associated Insertion(s)

Doc{}Antp^73b

Caused by aberration

In(3R)Antp^73b

Cytology

Description

Inversion breakpoint in Antp.

(Bermingham et al., 1990)

Inversion breakpoint is 45kb upstream of the P2 start site.

(Boulet and Scott, 1988)

Inversion between Doc{}sas^Doc (in first intron of sas) and Doc{}Antp^Doc (in first intron of Antp) causes an exchange between the proximal exons of Antp and sas.

(Schneuwly et al., 1987)

Proximal inversion breakpoint is at map position +178-182.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | dominant

(Abbott and Kaufman, 1986)

lethal | recessive

(Scott et al., 1983, Kaufman et al., 1980)

viable (with Antp¹)

(Southworth and Kennison, 2002)

viable (with Antp²³)

(Southworth and Kennison, 2002)

visible

(Gutierrez et al., 2003, Bhojwani et al., 1997)

visible | dominant

(Möller et al., 2005, Kankel et al., 2004, Brizuela and Kennison, 1997)

visible | dominant | homeotic

(Vazquez et al., 1999, Possidente et al., 1990, Jorgensen and Garber, 1987)

visible | homeotic

(Emerald and Cohen, 2004, Abbott and Kaufman, 1986)

Phenotype Manifest In

Detailed Description

Statement

Reference

100% of heterozygotes show transformation of antenna to leg.

(Möller et al., 2005)

Mutants show extensive transformation of antenna to leg.

(Emerald and Cohen, 2004)

Only 55% of heterozygotes show normal arista development.

(Kankel et al., 2004)

100% of mutant flies show an antenna to leg transformation.

(Gutierrez et al., 2003)

Heterozygous males do not show any change in the level of monoene cuticular hydrocarbons compared to wild-type males. Heterozygous females do not show any significant change in the level of monoene or 7,11-diene cuticular hydrocarbons compared to wild-type females.

(Wicker-Thomas and Jallon, 2001)

Heterozygous flies show transformation of antenna to leg. This phenotype is not suppressed by one copy of osa¹ or osa².

(Vazquez et al., 1999)

No gross morphological defects in the brain are seen in homozygous embryos.

(Hirth et al., 1998)

Antenna to leg transformation. Heterozygotes display minaturised maxillary palps, characterised by fewer bristles. Heterozygotes exhibit reduced compound eye and ommatidia are replaced by micro- and macrochaetae.

(Bhojwani et al., 1997)

Heterozygotes show differentiation of leg structures in the antennae. The penetrance and expressivity of this phenotype is unaffected if the flies are also heterozygous for mor¹ or mor².

(Brizuela and Kennison, 1997)

None of the ash2 alleles affect the expressivity or penetrance of the antenna to leg transformation.

(Adamson and Shearn, 1996)

pb^hs.PB cannot redirect phenotype of antennae from ectopic leg to maxillary palp.

(Cribbs et al., 1995)

Shows a small patch of untransformed antennal tissue remaining on the homeotic femur. Size of this patch varies 6-fold across different genetic backgrounds. Effects of maternal parent, sex and sex-linkage have been observed.

(Possidente et al., 1990)

Transformation of head to thoracic tissue.

(Jorgensen and Garber, 1987)

Homeotic transformation of antennae to mesothoracic legs.

(Abbott and Kaufman, 1986)

Antennae to leg transformation.

(Scott et al., 1983)

Transformation of antenna to prothoracic leg identity.

(Lewis et al., 1980)

A strong allele.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Antp^73b has visible phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^73b has visible phenotype, enhanceable by tsh⁸

(Bhojwani et al., 1997)

Antp^73b has visible phenotype, enhanceable by tsh⁷⁵

(Bhojwani et al., 1997)

NOT suppressed by

Statement

Reference

Antp^73b has visible | dominant phenotype, non-suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^73b has visible | dominant phenotype, non-suppressible by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

Antp^73b has visible | dominant phenotype, non-suppressible by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

Antp^73b has visible | dominant phenotype, non-suppressible by Gug³³³³/Gug[+]

(Kankel et al., 2004)

Antp^73b has visible | dominant phenotype, non-suppressible by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

Antp^73b has visible phenotype, non-suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^73b has visible phenotype, non-suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^73b has visible phenotype, non-suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

NOT Suppressor of

Statement

Reference

Antp^73b is a non-suppressor of visible | somatic clone phenotype of bowl¹

(Brás-Pereira and Casares, 2008)

Other

Statement

Reference

Antp^73b, toy^D2 has visible | homeotic phenotype

(Papadopoulos et al., 2011)

Antp^73b, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

Antp^73b, ct^C145 has visible phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^73b, tsh⁷⁵ has visible | recessive phenotype

(Bhojwani et al., 1997)

Antp^73b, tsh⁸ has visible | dominant phenotype

(Bhojwani et al., 1997)

Antp^73b, tsh¹⁷ has visible | dominant phenotype

(Bhojwani et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^73b has antenna phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^73b has eye phenotype, enhanceable by tsh⁷⁵

(Bhojwani et al., 1997)

Antp^73b has leg | ectopic phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^73b has antenna phenotype, enhanceable by tsh⁸

(Bhojwani et al., 1997)

Antp^73b has leg | ectopic phenotype, enhanceable by tsh⁸

(Bhojwani et al., 1997)

Antp^73b has antenna phenotype, enhanceable by tsh⁷⁵

(Bhojwani et al., 1997)

Antp^73b has leg | ectopic phenotype, enhanceable by tsh⁷⁵

(Bhojwani et al., 1997)

Antp^73b has ommatidium phenotype, enhanceable by tsh⁷⁵

(Bhojwani et al., 1997)

NOT suppressed by

Statement

Reference

Antp^73b has antenna phenotype, non-suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^73b has leg | ectopic phenotype, non-suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^73b has arista phenotype, non-suppressible by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

Antp^73b has arista phenotype, non-suppressible by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

Antp^73b has arista phenotype, non-suppressible by Gug³³³³/Gug[+]

(Kankel et al., 2004)

Antp^73b has arista phenotype, non-suppressible by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

Antp^73b has antenna phenotype, non-suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^73b has antenna phenotype, non-suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^73b has antenna phenotype, non-suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

Antp^73b has leg | ectopic phenotype, non-suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^73b has leg | ectopic phenotype, non-suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^73b has leg | ectopic phenotype, non-suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

NOT Suppressor of

Statement

Reference

Antp^73b is a non-suppressor of eye-antennal disc | somatic clone phenotype of bowl¹

(Brás-Pereira and Casares, 2008)

Other

Statement

Reference

Antp^73b, toy^D2 has eye phenotype

(Papadopoulos et al., 2011)

Antp^73b, toy^D2 has wing | ectopic phenotype

(Papadopoulos et al., 2011)

Antp^73b, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^73b, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Antp^73b, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp^73b, ct^C145 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^73b, ct^C145 has pronotum phenotype

(Johnston et al., 1998)

Antp^73b, ct^C145 has postpronotum phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^73b, tsh⁷⁵ has ommatidium phenotype

(Bhojwani et al., 1997)

Antp^73b, tsh⁷⁵ has antenna phenotype

(Bhojwani et al., 1997)

Antp^73b, tsh⁸ has antenna phenotype

(Bhojwani et al., 1997)

Antp^73b, tsh¹⁷ has antenna phenotype

(Bhojwani et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Antp^73b toy^D2 mutants show eye-to-wing transformations.

(Papadopoulos et al., 2011)

Somatic mutant bowl¹ clones induced in the ventral region of the antennal imaginal disc during stage L1 in Antp^73b mutant larvae result in the formation of ectopic, supernumerary appendages.

(Brás-Pereira and Casares, 2008)

The antenna to leg transformation phenotype seen in Antp^73b/+ flies is not suppressed by Bap60¹/+.

(Möller et al., 2005)

obk¹, Antp^73b (or Antp^Ns), hth^dtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae.

(Dworkin et al., 2001)

Eye phenotype is enhanced in a tsh⁷⁵ mutant background.

(Bhojwani et al., 1997)

Not enhanced or suppressed by brm¹.

(Tamkun et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

2259

In(3R)Antp^73b, Antp^73b sas^Antp73b red¹ e¹/TM3, Ser¹

2111

In(3R)Antp^73b, Ki¹ pb⁴ Antp^73b sas^Antp73b ss^a/TM3, Sb¹

Kyoto

106758

In(3R)Antp^73b, Antp^73b sas^Antp73b red¹ e¹/TM3, Sb¹

106666

In(3R)Antp^73b, Ki¹ pb⁴ Antp^73b sas^Antp73b ss^a/TM3, Sb¹

Notes on Origin

Discoverer

Green.

Induced on: red¹ e¹.

(Johnston et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Antp 73b

(Wicker-Thomas and Jallon, 2001)

Antp⁷³

(Riede, 2004, Duncan, 1982)

Antp^73B

(Johnston et al., 1998)

Antp^73b

(Ahn et al., 2011, Papadopoulos et al., 2011, Brás-Pereira and Casares, 2008, Prince et al., 2008, Möller et al., 2005, Riede, 2004)

Name Synonyms

Secondary FlyBase IDs

References (41)

Report Sections

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