FlyBase Allele Report: Dmel\ct[L188]

General Information

Symbol

Dmel\ct^L188

Species

D. melanogaster

Name

FlyBase ID

FBal0030982

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

transposable element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Johnston et al., 1998, Ostrow and Blochlinger, 1995)

Mutagen

transposable element activity

(Jackson and Blochlinger, 1997)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive | cold sensitive

(Johnston et al., 1998)

viable

(Jackson and Blochlinger, 1997)

Phenotype Manifest In

egg chamber

(Jackson and Berg, 1999)

Detailed Description

Statement

Reference

At 18^oC ct^L188/ct^C145 is essentially lethal, whereas at 24^oC ~50% flies eclose and appear morphologically normal.

(Johnston et al., 1998)

Egg chambers of ct^L188/ct^C145 females sometimes contain two diploid nuclei, and the distribution of ring canals may be abnormal. Egg chambers of ct^L188/ct^db10 females sometimes contain a multinucleate nurse cell but no detectable oocyte.

(Jackson and Blochlinger, 1997)

Homozygous viable. Lethal in combination with ct^C145.

(Ostrow and Blochlinger, 1995)

Homozygous embryos fail to transform ES organs to CH organs.

(Liu et al., 1991)

No embryonic phenotype.

(Blochlinger et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp², ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^CB, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp²⁵, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp¹⁶, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp²², ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188/ct^C145 has visible phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has visible phenotype

(Johnston et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

ct^L188 has phenotype, enhanceable by capu[+]/capu^HK3

(Jackson and Berg, 1999)

ct^L188/ct^db10 has nurse cell phenotype, enhanceable by Pka-C1⁰¹²⁷²

(Jackson and Blochlinger, 1997)

NOT Enhanced by

Statement

Reference

ct^L188 has phenotype, non-enhanceable by chic[+]/chic⁰⁷⁸⁸⁶

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by chic[+]/chic^k13321

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by arm⁴/arm[+]

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by spir[+]/spir¹

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by spir²/spir[+]

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by Src64B^Δ17/Src64B[+]

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by qua[+]/qua⁹

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by Egfr[+]/Egfr^f24

(Jackson and Berg, 1999)

ct^L188 has phenotype, non-enhanceable by Btk29A[+]/Btk^k00206

(Jackson and Berg, 1999)

Other

Statement

Reference

capu^HK3, ct^L188 has egg chamber phenotype

(Jackson and Berg, 1999)

Antp², ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp^CB, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^CB, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^CB, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp², ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp², ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp¹⁶, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp¹⁶, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp¹⁶, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp²⁵, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp²², ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp²², ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp²⁵, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp²², ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Df(3R)Scr, ct^L188 has pseudotrachea phenotype

(Johnston et al., 1998)

Df(3R)Scr, ct^L188 has labellum phenotype

(Johnston et al., 1998)

Df(3R)MAP2, ct^L188 has pseudotrachea phenotype

(Johnston et al., 1998)

Df(3R)MAP2, ct^L188 has labellum phenotype

(Johnston et al., 1998)

Df(3R)MAP8, ct^L188 has pseudotrachea phenotype

(Johnston et al., 1998)

Df(3R)MAP8, ct^L188 has labellum phenotype

(Johnston et al., 1998)

ct^L188, pb¹ has pseudotrachea phenotype

(Johnston et al., 1998)

ct^L188, pb¹ has labellum phenotype

(Johnston et al., 1998)

ct^L188, pb⁵ has pseudotrachea phenotype

(Johnston et al., 1998)

Antp²⁵, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

ct^L188, pb⁵ has labellum phenotype

(Johnston et al., 1998)

ct^L188, pb¹⁴ has pseudotrachea phenotype

(Johnston et al., 1998)

ct^L188, pb¹⁴ has labellum phenotype

(Johnston et al., 1998)

ct^L188, pb²⁷ has pseudotrachea phenotype

(Johnston et al., 1998)

ct^L188, pb²⁷ has labellum phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188/ct^C145 has humeral bristle phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188/ct^C145 has pronotum phenotype

(Johnston et al., 1998)

Antp¹¹, ct^L188/ct^C145 has postpronotum phenotype

(Johnston et al., 1998)

Antp^73b, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

capu^HK3 enhances the frequency of binucleate cell production in the egg chambers of ct^C145/ct^L188 and ct^db7/ct^L188 animals. Src64B^Δ17, qua⁹, Egfr^f24, Btk29A^k00206, spir¹, spir², arm⁴/+, chic⁰⁷⁸⁸⁶/+ or chic^k13321/+ do not interact with ct^C145/ct^L188. chic^k13321/+ does not interact with ct^db7/ct^L188.

(Jackson and Berg, 1999)

All flies of the genotype ct^L188/Y;Df(3R)Scr/+ show defective mouthparts. Number of pseudotrachea often reduced in ct^L188, but moreso in combination with Df(3R)Scr/+ and structures characteristic of legs and/or antennae are present. The phenotype shows 100% penetrance but variable expressivity. This phenotype resembles that of pb mutants. Similar phenotype occurs for other combinations with deficiencies e.g. Df(3R)MAP2 or Df(3R)MAP8 that remove pb and with pb¹, pb⁵, pb¹⁴ and pb²⁷, though not with Df(3R)LIN. The transformations seen in ct; pb/+ flies is less severe than that seen for e.g. pb¹/pb⁵ flies. In 22% of ct^L188 males in heterozygous combination with Antp¹¹, ectopic structures project (usually unilaterally) from the position of the anterior spiracle on the dorsal prothorax, and are associated with malformation of absence of the two macrochaetae on the humeral callus. The phenotype is reminiscent of that of Antp allelic combinations and is increased at 18^oC. 63% of ct^L188/ct^C145; Antp¹¹/+ flies show this phenotype at 24^oC.

(Johnston et al., 1998)

The frequency and severity of the ct^L188/ct^db10 multinucleate cell phenotype is enhanced by Pka-C1⁰¹²⁷². Ovaries from ct^L188/+; RpII140^wimp/+ females show no abnormal phenotype.

(Jackson and Blochlinger, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

lethal IV cut phenotypic class.

(Blochlinger et al., 1990)

ct^L188 fails to complement ct^C145 and ct^lS1, and alleles of the cut wing and kinked femur phenotypic class.

(Liu et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ct¹⁸⁸

(Ostrow and Blochlinger, 1995)

ct^L188

Name Synonyms

Secondary FlyBase IDs

References (7)

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