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General Information
Symbol
Dmel\capuHK3
Species
D. melanogaster
Name
FlyBase ID
FBal0030718
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
capuHK
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T3873891C

Amino acid change:

I751T | capu-PA; I741T | capu-PB; I899T | capu-PD; I972T | capu-PE; I1053T | capu-PF; I624T | capu-PG; I799T | capu-PH; I990T | capu-PI; I781T | capu-PJ

Reported amino acid change:
Comment:

Site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change; CDS from reference sequence longer by 1 amino acid than published CDS in GB:U34258 and thus the mutation coordinates differ by 1

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: I750T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous egg chambers do not contain binucleate cells.

hts RNA localization unaltered in embryos derived from capu mutant mothers.

Variable expansion (dorsalization) of dorsal appendages, at expense of main body shell. Absence of polar granules, pole cells and abdominal segments in embryos.

Homozygous mothers produce dorsalized egg shells and embryos. The first sign of dorsalization in embryos can be seen during gastrulation, when the ventral furrow is reduced or absent. Dorsalization in the egg chamber is evident in the shape of the follicle cells. While the number of follicle cells around the main body of the egg shell is reduced, dorsal appendages are expanded, often fused dorsally and/or extended ventrally. The embryos lack polar granules and pole cells, and show cellularization defects. Embryos show abdominal segmentation defects similar to those produced by mutations in the grandchildless-knirps or posterior class of maternal effect loci. A small fraction of the offspring survive to adulthood, and are agametic.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

capu[+]/capuHK3 is an enhancer of phenotype of ctdb7

capu[+]/capuHK3 is an enhancer of phenotype of ctL188

capu[+]/capuHK3 is an enhancer of phenotype of ctC145

capu[+]/capuHK3 is an enhancer of egg phenotype of Ets97Dtne-1

Other
Additional Comments
Genetic Interactions
Statement
Reference

capuHK3 does not interact with ctC145 in a doubly heterozygous background, although it does enhance the frequency of binucleate cell production in the egg chambers of ctC145/ctL188 animals. capuHK3 does not interact with ctdb7 in a doubly heterozygous background, although it does enhance the frequency of binucleate cell production in the egg chambers of ctdb7/ctL188 animals.

One copy of capuHK3 decreases the number of eggs laid by Ets97Dtne-1/Df(3R)ro80b females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Does not interact with RpII140wimp maternal effect.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0030719
References (12)