FlyBase Allele Report: Dmel\ct[db7]

General Information

Symbol

Dmel\ct^db7

Species

D. melanogaster

Name

FlyBase ID

FBal0001960

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

diepoxybutane

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Sun and Deng, 2005, Brewster and Bodmer, 1995)

Mutagen

diepoxybutane

Progenitor genotype

Cytology

Description

Contains a 1kb deletion in 130-150kb, encoding a protein lacking the homeodomain.

(Sun and Deng, 2005)

Mutation in the coding region.

(Morcillo et al., 1996)

Small deletion in the ct gene of about 1kb.

(Brewster and Bodmer, 1995)

Protein lacks the homeobox.

(Jack et al., 1991)

1 kb deletion in 130 to 150 kb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Hardiman et al., 2002)

decreased cell number | oogenesis | somatic clone

(Sun and Deng, 2005)

decreased cell number | somatic clone

(Sun and Deng, 2005)

lethal

(Blochlinger et al., 1990)

lethal | recessive

(Morcillo et al., 1996, Brewster and Bodmer, 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

Enhanced cell death is seen in the filzkorper precursor cells of stage 11 mutant embryos compared to in wild type.

(Zhai et al., 2012)

ct^db7 mutant follicle-cell clones exhibit larger nuclei than their wild-type neighbours. The numbers of cells in the mutant clones are significantly lower than in the sister wild-type clone. Typically, 2-8 cells are found in each ct^db7 mutant cell clone, compared to a 2- to 5-fold greater number of cells in the wild-type clone. ct^db7 clones, in which ct function is lost during early oogenesis, are driven to differentiate earlier than in wild-type cells, indicating ct is required to maintain the follicle cells in mitosis.

(Sun and Deng, 2005)

Homozygous embryos show transformation of external sensory organs into chordotonal organs.

(Hardiman et al., 2002)

Extra nub expressing multidendritic (md) neurons are seen in mutant embryos. There are usually two ectopic nub expressing neurons in the dorsal cluster, and two in the lateral cluster.

(Brewster et al., 2001)

The stigmatophore protrudes normally but the spiracular chamber is defective in that the filzkorper is almost missing, the trachea is still connected to the spiracular chamber and the spiracular hairs are also missing.

(Hu and Castelli-Gair, 1999)

The identity of the AS-C-dependent md neurons has changed to what seems to be characteristic of a subset of at-dependent md neurons.

(Brewster and Bodmer, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(1)A209, ct^db7 has visible | dominant phenotype

(Jackson and Berg, 1999)

Df(1)sd72b, ct^db7 has visible | dominant phenotype

(Jackson and Berg, 1999)

Df(1)JA26, ct^db7 has lethal phenotype

(Jackson and Berg, 1999)

Df(3R)P14, ct^db7 has lethal phenotype

(Jackson and Berg, 1999)

Df(3R)Tl-P, ct^db7 has partially lethal phenotype

(Jackson and Berg, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

ct^db7 has phenotype, enhanceable by capu[+]/capu^HK3

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(2R)or-BR6/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(2R)M60E/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3L)GN50/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3L)GN24/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3L)66C-G28/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3L)AC1/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3L)W4/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3R)Antp17/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3R)P14/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(3R)Tl-P/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(1)JC70/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(1)RA2/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(1)KA14/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(1)N105/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(1)JA26/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(2L)30A-C/+

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by +/Df(2R)44CE

(Jackson and Berg, 1999)

ct^db7 has egg chamber phenotype, enhanceable by Df(2R)eve/+

(Jackson and Berg, 1999)

NOT Enhanced by

Statement

Reference

ct^db7 has phenotype, non-enhanceable by chic[+]/chic^k13321

(Jackson and Berg, 1999)

Other

Statement

Reference

Df(2L)32FP-5, ct^db7, dome^G0468 has embryonic/larval spiracle phenotype

(Lovegrove et al., 2006)

Df(2L)32FP-5, ct^db7, dome^G0468, ems² has embryonic/larval spiracle phenotype

(Lovegrove et al., 2006)

Df(1)A209, ct^db7 has macrochaeta phenotype

(Jackson and Berg, 1999)

Df(1)sd72b, ct^db7 has wing phenotype

(Jackson and Berg, 1999)

capu^HK3, ct^db7 has egg chamber phenotype

(Jackson and Berg, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

In ct^db7, dome^G0468, Df(2L)32FP-5 (deficiency for sal) triple mutants, no obvious spiracle structures remain, but the trachea still joins to the outside.

Quadruple ct^db7, Df(2L)32FP-5 (deficiency for sal), ems², dome^G0468 mutants are missing spiracle structures completely.

(Lovegrove et al., 2006)

capu^HK3 does not interact with ct^db7 in a doubly heterozygous background, although it does enhance the frequency of binucleate cell production in the egg chambers of ct^db7/ct^L188 animals. chic^k13321/+ does not interact with ct^db7/ct^L188. ct^db7 produces egg chambers with binucleate cells in double heterozygous combination with a number of deficiencies; Df(1)JC70, Df(1)RA2, Df(1)KA14, Df(1)N105, Df(1)JA26, Df(2L)30A-C, Df(2R)44CE, Df(2R)eve, Df(2R)or-BR6, Df(2R)M60E, Df(3L)GN50, Df(3L)GN24, Df(3L)66C-G28, Df(3L)AC1, Df(3L)W4, Df(3R)Antp17, Df(3R)P14 and Df(3R)Tl-P. Dominantly enhances the wing notching phenotype seen in Df(1)N-8/+ flies; notches are deeper and more frequent. Double heterozygotes with Df(1)sd72b show a wing notching phenotype. ct^db7/Df(1)A209 flies have shortened and tapered bristles.

(Jackson and Berg, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

78562

y¹ w^* ct^db7/FM7c, P{ftz-lacC}YH1

Notes on Origin

Discoverer

Comments

lethal II cut phenotypic class.

(Blochlinger et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ct^DB7

(Jackson and Berg, 1999, Jack et al., 1991)

ct^db7

(Molina-Gil et al., 2023, Zhai et al., 2012, Zartman et al., 2008, Bhat, 2007, Krattinger et al., 2007, Lovegrove et al., 2006)

cut^DB7

(Levine et al., 2010)

Name Synonyms

Secondary FlyBase IDs

FBal0045480

References (19)

Report Sections

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