FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(3L)W4
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General Information
Symbol
Df(3L)W4
Species
D. melanogaster
Name
Deficiency (3L) Wrinkled
FlyBase ID
FBab0002358
Feature type
chromosomal_deletion
Also Known As
Df(3L)WR4, Df(3L)Wr4, Df(3L)w+R4
Computed Breakpoints include

75B10;75C5

Features within 75B10--75C5
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Abbott and Lengyel, 1991)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Salzberg et al., 1997, Addison et al., 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Birchler et al., 1994, Abbott and Lengyel, 1991, Segraves and Hogness, 1990)
Breakpoints

75B8-76B11;75C5-75C7

(Segraves and Hogness, 1990)

75B;75C4

(Abbott and Lengyel, 1991)

75B10;75C1-75C2

(Harbecke and Lengyel, 1995, Birchler et al., 1994)

75B8-75B11;75C5-75C7

(Salzberg et al., 1997, Addison et al., 1995, Pauli et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

Eip75B << bk1 << W << ads << bk2 << l(3)j13B3

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Segraves and Hogness, 1990)
Comments on Cytology

Ref: FBrf0051843.

(Abbott and Lengyel, 1991)

Limits of break 1 from polytene analysis (FBrf0074960) Left limit of break 2 from polytene analysis (FBrf0051843) Right limit of break 2 from non-inclusion of l(3)j13B3 (FBrf0067338)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Loss of heterozygosity is elevated compared to wild-type in Df(3L)x37/Df(3L)W4 animals. Df(3L)x37/Df(3L)W4 animals have macrochaetae defects (probably due genomic instability resulting in the loss of genetic material at haploinsufficient Minute loci).

    (Brodsky et al., 2000)

    Lethal in combination with Df(3L)GR844X22. Complements Df(3L)Δ26, Df(3L)Δ32, Df(3L)Δ54, Df(3L)Δ215, Df(3L)Δ3002, Df(3L)GR844X31 and Df(3L)GR844X33.

    (Addison et al., 1995)
    NOT in combination with other aberrations

    Flies heterozygous for the deletion do not show a Minute bristle phenotype.

    (Marygold et al., 2007)

    The Df(3L)W4 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(3L)W4 results in 0.7% X chromosome nondisjunction and 0.3% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Dominantly enhances the KrIf-1/+ eye phenotype.

    (Carrera et al., 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)

    Homozygous embryos are very abnormal compared to wild-type.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Number of cells expressing midline glial cell markers in the embryonic CNS is increased by 60%.

    (Sonnenfeld and Jacobs, 1995)

    Homozygotes show the full cell death defective phenotype.

    (White et al., 1994)

    75B puff is unchanged.

    (Segraves and Hogness, 1990)
    Stocks (2)
    Notes on Origin
    Discoverer

    Segraves.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (13)
    References (45)