FlyBase Allele Report: Dmel\Antp[R]

General Information

Symbol

Dmel\Antp^R

Species

D. melanogaster

Name

of Rapoport

FlyBase ID

FBal0000615

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(3R)Antp^R

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

viable (with Antp¹)

(Southworth and Kennison, 2002)

viable (with Antp²³)

(Southworth and Kennison, 2002)

visible | dominant

visible | homeotic

(Lewis et al., 1980)

Phenotype Manifest In

antenna

(Cribbs et al., 1995, Lewis et al., 1980)

mesothoracic leg | ectopic

(Cribbs et al., 1995)

mesothoracic preepisternum

Detailed Description

Statement

Reference

Transformation of antenna to prothoracic leg identity.

(Lewis et al., 1980)

Segments added to antennae, usually distal to aristae. Claw occasionally at end of antenna. Asymmetry pronounced. Rarely an antenna-like organ on sternopleura. Enhanced by D¹. Lethal in combination with Antp^B (Von Halle, cited in FBrf0066905). RK3A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp^R, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^R, ct^C145 has visible phenotype

(Johnston et al., 1998)

Phenotype Manifest In

Other

Statement

Reference

Antp^R, ct^L188 has postpronotum phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^R, ct^L188 has pronotum phenotype

(Johnston et al., 1998)

Antp^R, ct^C145 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^R, ct^C145 has pronotum phenotype

(Johnston et al., 1998)

Antp^R, ct^C145 has postpronotum phenotype

(Johnston et al., 1998)

Antp^R, pb^hs.PB has antenna phenotype

(Cribbs et al., 1995)

Antp^R, pb^hs.PB has maxillary palp | ectopic phenotype

(Cribbs et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

In heterozygous combination with ct^L188 or ct^C145, ectopic structures project (usually unilaterally) from the position of the anterior spiracle on the dorsal prothorax, and are associated with malformation of absence of the two macrochaetaes on the humeral callus. The phenotype is incompletely penetrant and not as severe as for Antp¹¹.

(Johnston et al., 1998)

Homeotic transformation of antennae to T2 leg seen in Antp^R flies can be redirected by pb^hs.PB from ectopic leg to maxillary palp.

(Cribbs et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Antp^B

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1437

In(3R)Antp^R, Antp^R/TM6B, Tb¹

Kyoto

106313

In(3R)Antp^R, Antp^R/TM6B, Tb¹

Notes on Origin

Discoverer

Rappaport, 1963.

Comments

Variable expression but expressivity 100% in combination with D. Moderate dominant allele.

The wing positioning defects in In(3R)Antp^R flies were previously attributed to an effect on Antp (FBrf0107412 and FBrf0155711), however, complementation analysis in FBrf0204343 indicates that the Glut4EF gene is also disrupted by the In(3R)Antp^R chromosome and suggests that the wing positioning defects are caused instead by an effect on Glut4EF.

(Yazdani et al., 2008)

FlyBase curator comment: FBrf0155711 attributes the wing positioning defects in In(3R)Antp^R flies to an effect on Antp. However, complementation analysis in FBrf0204343 indicates that the Glut4EF gene is also disrupted by the In(3R)Antp^R chromosome and suggests that the wing positioning defects are caused instead by an effect on Glut4EF.

(Gutierrez et al., 2003)

FlyBase curator comment: FBrf0107412 attributes the wing positioning defects in In(3R)Antp^R flies to an effect on Antp. However, complementation analysis in FBrf0204343 indicates that the Glut4EF gene is also disrupted by the In(3R)Antp^R chromosome and suggests that the wing positioning defects are caused instead by an effect on Glut4EF.

(Vazquez et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Antp^R

ss^A

Name Synonyms

of Rapoport

spineless-Aristapedia Dominant

Secondary FlyBase IDs

References (11)

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