FlyBase Allele Report: Dmel\tna[1]

General Information

Symbol

Dmel\tna¹

Species

D. melanogaster

Name

FlyBase ID

FBal0143158

Feature type

allele

Associated gene

Dmel\tna

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Monribot-Villanueva et al., 2013)

Mutagen

ethyl methanesulfonate

(Gutierrez et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q566term.

(Gutierrez et al., 2003)

Nucleotide substitution: C?T.

(Gutierrez et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:10,872,449..10,872,449 [+]

Nucleotide change:

C10872449T

Reported nucleotide change:

C?T

Amino acid change:

Q592term | tna-PA; Q606term | tna-PB; Q566term | tna-PD; Q643term | tna-PE

Reported amino acid change:

Q566term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Figure 4 of FBrf0155711 shows location of amino acid substitution.

(Gutierrez et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

haltere (with tna^L6731)

(Gutierrez et al., 2003)

haltere (with tna^rI075)

(Gutierrez et al., 2003)

haltere (with tna^S058302)

(Gutierrez et al., 2003)

sex comb (with tna^L6731)

(Gutierrez et al., 2003)

sex comb (with tna^rI075)

(Gutierrez et al., 2003)

sex comb (with tna^S058302)

(Gutierrez et al., 2003)

wing

(Monribot-Villanueva et al., 2013, Vázquez et al., 2008, Gutierrez et al., 2003)

wing | ectopic (with tna^L6731)

(Gutierrez et al., 2003)

wing | ectopic (with tna^rI075)

(Gutierrez et al., 2003)

wing | ectopic (with tna^S058302)

(Gutierrez et al., 2003)

Detailed Description

Statement

Reference

tna¹/tna⁵ larvae do not have melanotic tumors, nor are they larger in size than wild type.

65% of tna¹/tna⁵ animals reach third instar larval stage, but only 41% pupate, and only 8% of the expected number reach pharate stage. No tna¹/tna⁵ animals eclose as adults. The tna¹/tna⁵ third instar larvae that fail to pupate often survive long after the pupation of their heterozygous siblings. The lifespan of some of the tna¹/tna⁵ larvae extends to at least two weeks. In contrast to wild-type late stage third instar larvae, tna¹/tna⁵ continue feeding.

tna¹/+ flies show a slight held-out wing phenotype.

(Monribot-Villanueva et al., 2013)

17% of heterozygotes have a held-out wing phenotype.

(Vázquez et al., 2008)

tna¹/tna^rI075, tna¹/tna^S058302 and tna¹/tna^L6731 flies can have a partial transformation of haltere to wing. 17% of heterozygous flies have a held-out wings phenotype. tna¹/tna^rI075, tna¹/tna^S058302 and tna¹/tna^L6731 flies show a reduction in the number of sex combs on the first leg. tna¹/Df(3L)lxd6 animals dervied from tna¹ homozygous female germline clones (these animals lack both maternal and zygotic tna function) generally die as third instar larvae, although a few animals reach the pharate adult stage. These pharate animals have fewer sex comb teeth in the male first legs than normal and show a haltere to wing transformation. tna¹/+ animals derived from tna¹ homozygous female germline clones (these animals lack maternal but not zygotic tna function) develop to normal, fertile adults.

(Gutierrez et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tna¹ has visible | dominant phenotype, enhanceable by osa¹/osa[+]

(Monribot-Villanueva et al., 2013)

tna¹ has visible | dominant phenotype, enhanceable by Sumo⁰⁴⁴⁹³/smt3[+]

(Monribot-Villanueva et al., 2013)

tna¹ has visible | dominant phenotype, enhanceable by lwr[+]/lwr^4-3

(Monribot-Villanueva et al., 2013)

tna¹ has visible | dominant phenotype, enhanceable by lwr¹³/lwr[+]

(Monribot-Villanueva et al., 2013)

tna¹ has visible | dominant phenotype, enhanceable by γTub23C^Pl-2

(Vázquez et al., 2008)

tna¹ has visible | dominant phenotype, enhanceable by mor²

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by osa¹

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by skd²

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by skd^L7062

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by brm²

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by skd^rK760

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by tara²⁰

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by tara²

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by kis¹

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by kis^k13416

(Gutierrez et al., 2003)

tna¹ has visible | dominant phenotype, enhanceable by mor¹

(Gutierrez et al., 2003)

Enhancer of

Statement

Reference

tna¹ is an enhancer of visible | dominant phenotype of brm²

(Gutierrez et al., 2003)

tna¹ is an enhancer of visible | dominant phenotype of osa¹

(Gutierrez et al., 2003)

tna¹ is an enhancer of visible | dominant phenotype of tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

Suppressor of

Statement

Reference

tna¹ is a suppressor of visible | dominant phenotype of Pc⁴

(Gutierrez et al., 2003)

tna¹ is a suppressor of visible | dominant phenotype of Scr^Msc

(Gutierrez et al., 2003)

tna[+]/tna¹ is a suppressor of visible phenotype of Antp^Ns

(Gutierrez et al., 2003)

tna¹ is a suppressor of visible | dominant phenotype of Pc³

(Gutierrez et al., 2003)

NOT Suppressor of

Statement

Reference

tna[+]/tna¹ is a non-suppressor of visible phenotype of Antp^73b

(Gutierrez et al., 2003)

Other

Statement

Reference

Glut4EF^Antp-B, tna[+]/tna¹ has visible | dominant phenotype

(Gutierrez et al., 2003)

Glut4EF^Antp-R, tna[+]/tna¹ has visible | dominant phenotype

(Gutierrez et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

tna¹ has wing phenotype, enhanceable by osa¹/osa[+]

(Monribot-Villanueva et al., 2013)

tna¹ has wing phenotype, enhanceable by Sumo⁰⁴⁴⁹³/smt3[+]

(Monribot-Villanueva et al., 2013)

tna¹ has wing phenotype, enhanceable by lwr[+]/lwr^4-3

(Monribot-Villanueva et al., 2013)

tna¹ has wing phenotype, enhanceable by lwr¹³/lwr[+]

(Monribot-Villanueva et al., 2013)

tna¹ has wing phenotype, enhanceable by γTub23C^Pl-2

(Vázquez et al., 2008)

tna¹ has wing phenotype, enhanceable by mor²

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by osa¹

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by skd²

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by skd^L7062

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by skd^rK760

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by tara²⁰

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by tara²

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by brm²

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by kis¹

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by kis^k13416

(Gutierrez et al., 2003)

tna¹ has wing phenotype, enhanceable by mor¹

(Gutierrez et al., 2003)

Enhancer of

Statement

Reference

tna¹ is an enhancer of wing phenotype of brm²

(Gutierrez et al., 2003)

tna¹ is an enhancer of wing phenotype of osa¹

(Gutierrez et al., 2003)

tna¹ is an enhancer of wing phenotype of tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

Suppressor of

Statement

Reference

tna¹ is a suppressor of mesothoracic leg phenotype of Pc⁴

(Gutierrez et al., 2003)

tna¹ is a suppressor of metathoracic leg phenotype of Pc⁴

(Gutierrez et al., 2003)

tna¹ is a suppressor of sex comb | ectopic phenotype of Pc⁴

(Gutierrez et al., 2003)

tna¹ is a suppressor of mesothoracic leg phenotype of Scr^Msc

(Gutierrez et al., 2003)

tna¹ is a suppressor of metathoracic leg phenotype of Scr^Msc

(Gutierrez et al., 2003)

tna¹ is a suppressor of sex comb | ectopic phenotype of Scr^Msc

(Gutierrez et al., 2003)

tna[+]/tna¹ is a suppressor of antenna phenotype of Antp^Ns

(Gutierrez et al., 2003)

tna[+]/tna¹ is a suppressor of leg | ectopic phenotype of Antp^Ns

(Gutierrez et al., 2003)

tna¹ is a suppressor of mesothoracic leg phenotype of Pc³

(Gutierrez et al., 2003)

tna¹ is a suppressor of metathoracic leg phenotype of Pc³

(Gutierrez et al., 2003)

tna¹ is a suppressor of sex comb | ectopic phenotype of Pc³

(Gutierrez et al., 2003)

NOT Suppressor of

Statement

Reference

tna[+]/tna¹ is a non-suppressor of antenna phenotype of Antp^73b

(Gutierrez et al., 2003)

tna[+]/tna¹ is a non-suppressor of leg | ectopic phenotype of Antp^73b

(Gutierrez et al., 2003)

Other

Statement

Reference

Glut4EF^Antp-B, tna[+]/tna¹ has wing phenotype

(Gutierrez et al., 2003)

Glut4EF^Antp-R, tna[+]/tna¹ has wing phenotype

(Gutierrez et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Trans-heterozygous tna¹, osa¹ double mutants show a stronger held-out wing phenotype than either of the single mutants.

smt3⁰⁴⁴⁹³/+ enhances both the penetrance and expressivity of the held-out wing phenotype of tna¹/+ flies. A maternal effect is observed in the enhancement of the tna¹/+ held out phenotype by smt3⁰⁴⁴⁹³/+.

lwr^4-3/+ enhances both the penetrance and expressivity of the held-out wing phenotype of tna¹/+ flies.

lwr¹³/+ enhances both the penetrance and expressivity of the held-out wing phenotype of tna¹/+ flies.

(Monribot-Villanueva et al., 2013)

γTub23C^Pl-2 results in a held-out wing phenotype in double heterozygous combination with tna¹ (75% penetrance).

(Vázquez et al., 2008)

100% of brm²/tna¹ flies have a held-out wings phenotype. 65% of tna¹/Glut4EF^Antp-R flies have a held-out wings phenotype. 75% of Glut4EF^Antp-B/tna¹ flies have a held-out wings phenotype. 100% of tna¹/osa¹ flies have a held-out wings phenotype. 100% of tara²/tna¹ flies have a held-out wings phenotype. 87% of tara²⁰/tna¹ flies have a held-out wings phenotype. 80% of tara⁰³⁸⁸¹/tna¹ flies have a held-out wings phenotype. tna¹ does not show a strong genetic interaction with Snr1⁰³¹⁹, kto¹, MED17^s2956, ash2¹, trx¹, trx⁰⁰³⁴⁷, urd² or sls¹.

100% of brm²/tna¹ flies have a held-out wings phenotype. 65% of tna¹/Antp^R flies have a held-out wings phenotype. 100% of tna¹/osa¹ flies have a held-out wings phenotype. 100% of tara²/tna¹ flies have a held-out wings phenotype. 87% of tara²⁰/tna¹ flies have a held-out wings phenotype. 80% of tara⁰³⁸⁸¹/tna¹ flies have a held-out wings phenotype. tna¹ does not show a strong genetic interaction with Snr1⁰³¹⁹, kto¹, MED17^s2956, ash2¹, trx¹, trx⁰⁰³⁴⁷, urd² or sls¹.

(Gutierrez et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tna^S058302

(Gutierrez et al., 2003)

tna^L6731

(Gutierrez et al., 2003)

tna^rI075

(Gutierrez et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tna¹

(Rosales-Vega et al., 2023, Monribot-Villanueva et al., 2013, Vázquez et al., 2008, Chang et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

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