FlyBase Allele Report: Dmel\Scr[Msc]

General Information

Symbol

Dmel\Scr^Msc

Species

D. melanogaster

Name

Multiple sex comb

FlyBase ID

FBal0015297

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

Also Known As

Msc, Msc¹

Key Links

Allele class

gain of function allele

loss of function allele

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Pattatucci and Kaufman, 1991)

gain of function allele

(Tamkun et al., 1992, Pattatucci and Kaufman, 1991, Pattatucci et al., 1991, Scott et al., 1983)

loss of function allele

(Pattatucci et al., 1991)

Mutagen

spontaneous

(Pattatucci et al., 1991, Scott et al., 1983)

Progenitor genotype

Caused by aberration

In(3R)Scr^Msc

Cytology

Description

Proximal inversion breakpoint is at map position +62-64.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Scott et al., 1983, Kaufman et al., 1980)

visible (with Df(3R)Scr), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

visible (with Scr⁴), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

visible | dominant

(Gutierrez et al., 2003, Southworth and Kennison, 2002, Scott et al., 1983, Kaufman et al., 1980)

visible | dominant | homeotic | heat sensitive

(Sinclair et al., 1984)

visible | homeotic

(Kankel et al., 2004)

Phenotype Manifest In

mesothoracic leg

(Kankel et al., 2004, Gutierrez et al., 2003, Southworth and Kennison, 2002, Scott et al., 1983, Lewis et al., 1980, Lewis et al., 1980)

mesothoracic leg (with Df(3R)Scr), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

mesothoracic leg (with Scr⁴), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

mesothoracic leg & sex comb | ectopic | conditional ts

(Sinclair et al., 1984)

mesothoracic leg | male

(Duncan and Kaufman, 1975)

metathoracic leg

(Kankel et al., 2004, Gutierrez et al., 2003, Southworth and Kennison, 2002, Scott et al., 1983, Lewis et al., 1980, Lewis et al., 1980)

metathoracic leg (with Df(3R)Scr), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

metathoracic leg (with Scr⁴), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

metathoracic leg | male

(Duncan and Kaufman, 1975)

prothoracic leg

(Lewis et al., 1980)

prothoracic leg | ectopic

(Kankel et al., 2004)

sex comb

(Southworth and Kennison, 2002, Lewis et al., 1980)

sex comb | ectopic

(Moazzen et al., 2009, Gutierrez et al., 2003, Southworth and Kennison, 2002, Duncan and Kaufman, 1975)

sex comb | ectopic (with Df(3R)Scr), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

sex comb | ectopic (with Scr⁴), with Dp(3;Y)77ab

(Southworth and Kennison, 2002)

Detailed Description

Statement

Reference

Mutants show a significant number of ectopic sex combs on the second leg.

(Moazzen et al., 2009)

Mutant adults show transformation of the second and third leg to first leg.

(Kankel et al., 2004)

100% of heterozygous males have sex comb teeth on the second and/or third leg. Expressivity of the phenotype is 23%.

(Gutierrez et al., 2003)

Heterozygous males have a reduced number of sex comb teeth on the first leg. Heterozygous males have an average of 3.2 ectopic sex comb teeth per second leg. Heterozygous males have an average of 1.4 ectopic sex comb teeth per third leg. Scr^Msc/Df(3R)Scr ; Dp(3;Y)77ab males have an average of 0.2 ectopic sex comb teeth per second leg. Scr^Msc/Df(3R)Scr ; Dp(3;Y)77ab males have an average of 0.1 ectopic sex comb teeth per third leg. Scr^Msc/Scr⁴ ; Dp(3;Y)77ab males have an average of 0.3 ectopic sex comb teeth per second leg. Scr^Msc/Scr⁴ ; Dp(3;Y)77ab males have an average of 0.1 ectopic sex comb teeth per third leg. Scr^Msc/Scr^Wrv4 males have no ectopic sex comb teeth on the second legs. Scr^Msc/Scr^Wrv4 males have no ectopic sex comb teeth on the third legs.

(Southworth and Kennison, 2002)

Dominant allele.

(Lindsley and Zimm, 1992)

Heterozygotes exhibit derepression of Scr in the second and third imaginal discs causes transformation to first leg identities. In the presence of two brm⁺ alleles 100% of flies show some transformation, only 10% in brm² heterozygotes.

(Tamkun et al., 1992)

Extra sex combs present an all six legs of males.

(Pattatucci and Kaufman, 1991)

Haplo-abnormal phenotype is suppressed by a duplication carrying Scr.

(Kennison and Russell, 1987)

Phenotype is enhanced by ph-d².

(Dura et al., 1985)

Heterozygous males have extra sex combs on the second legs. The penetrance of this phenotype is higher at 29^oC than at 22^oC.

(Sinclair et al., 1984)

Partial transformation of second and third legs into first legs.

(Scott et al., 1983)

Sex comb teeth are produced on the basitarsus of all six legs (transformation of meso- and metathoracic into prothoracic legs). Reduction in the number of sex comb teeth present on the prothoracic leg.

(Kaufman et al., 1980)

Transformation of prothoracic leg to mesothoracic leg identity and transformation of meso- and metathoracic leg to prothoracic leg identity.

(Lewis et al., 1980)

Males display reduced sex comb phenotype, indicating a transformation of meso- and metathoracic leg to prothoracic leg identity.

(Lewis et al., 1980)

Sex combs are present on the second and third leg of males.

(Duncan and Kaufman, 1975)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scr^Msc has visible | homeotic phenotype, suppressible by Gug¹⁷⁵⁷

(Kankel et al., 2004)

Scr^Msc has visible | homeotic phenotype, suppressible by Gug²²⁹⁵

(Kankel et al., 2004)

Scr^Msc has visible | homeotic phenotype, suppressible by Gug³³³³

(Kankel et al., 2004)

Scr^Msc has visible | homeotic phenotype, suppressible by Gug⁵¹⁹

(Kankel et al., 2004)

Scr^Msc has visible | dominant phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Scr^Msc has visible | dominant phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Scr^Msc has visible | dominant phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Scr^Msc has visible | dominant phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Scr^Msc has visible | dominant phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Scr^Msc has visible | dominant | homeotic | heat sensitive phenotype, suppressible by M(3)80[+]/M(3)80¹

(Sinclair et al., 1984)

Scr^Msc has visible | dominant | homeotic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Scr^Msc has visible | dominant | homeotic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

Other

Statement

Reference

Antp^Ns-rv2, Scr^Msc has lethal phenotype

(Duncan and Kaufman, 1975)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scr^Msc has sex comb | ectopic phenotype, enhanceable by Df(3R)ED5474/+

(Moazzen et al., 2009)

Scr^Msc has phenotype, enhanceable by Pcl¹

(Duncan, 1982)

NOT Enhanced by

Statement

Reference

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by Df(3R)BSC509/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by Df(3R)DG4/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by Df(3R)wrd-CG7208/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by PP2A-B'[+]/wrd^Δ

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by z¹

(Southworth and Kennison, 2002)

Scr^Msc has sex comb | ectopic phenotype, non-enhanceable by z^a

(Southworth and Kennison, 2002)

Suppressed by

Statement

Reference

Scr^Msc has sex comb | ectopic phenotype, suppressible by Df(3R)P14/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, suppressible by Df(3R)Exel6178/+

(Moazzen et al., 2009)

Scr^Msc has mesothoracic leg phenotype, suppressible by Gug¹⁷⁵⁷

(Kankel et al., 2004)

Scr^Msc has mesothoracic leg phenotype, suppressible by Gug²²⁹⁵

(Kankel et al., 2004)

Scr^Msc has mesothoracic leg phenotype, suppressible by Gug³³³³

(Kankel et al., 2004)

Scr^Msc has mesothoracic leg phenotype, suppressible by Gug⁵¹⁹

(Kankel et al., 2004)

Scr^Msc has prothoracic leg | ectopic phenotype, suppressible by Gug¹⁷⁵⁷

(Kankel et al., 2004)

Scr^Msc has prothoracic leg | ectopic phenotype, suppressible by Gug²²⁹⁵

(Kankel et al., 2004)

Scr^Msc has prothoracic leg | ectopic phenotype, suppressible by Gug³³³³

(Kankel et al., 2004)

Scr^Msc has prothoracic leg | ectopic phenotype, suppressible by Gug⁵¹⁹

(Kankel et al., 2004)

Scr^Msc has mesothoracic leg phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Scr^Msc has mesothoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Scr^Msc has mesothoracic leg phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Scr^Msc has mesothoracic leg phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Scr^Msc has mesothoracic leg phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Scr^Msc has metathoracic leg phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Scr^Msc has metathoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Scr^Msc has metathoracic leg phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Scr^Msc has metathoracic leg phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Scr^Msc has metathoracic leg phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Scr^Msc has sex comb | ectopic phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Scr^Msc has sex comb | ectopic phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Scr^Msc has sex comb | ectopic phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Scr^Msc has sex comb | ectopic phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Scr^Msc has sex comb | ectopic phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Scr^Msc has mesothoracic leg & sex comb | ectopic phenotype, suppressible by M(3)80[+]/M(3)80¹

(Sinclair et al., 1984)

Scr^Msc has mesothoracic leg & sex comb | ectopic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Scr^Msc has mesothoracic leg & sex comb | ectopic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

NOT suppressed by

Statement

Reference

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by Df(3R)BSC509/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by Df(3R)DG4/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by Df(3R)wrd-CG7208/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by PP2A-B'[+]/wrd^Δ

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by +/Df(3R)ED6265

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by PP2A-B'[+]/wrd^Δ/+/Df(3R)ED6265

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by PP2A-B'[+]/wrd^Δ/Df(3R)ED5474/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by Df(3R)ED6025/+

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by +/Df(2L)ED12527

(Moazzen et al., 2009)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by z^a

(Southworth and Kennison, 2002)

Scr^Msc has sex comb | ectopic phenotype, non-suppressible by z¹

(Southworth and Kennison, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Compared to Scr^Msc mutants alone, significantly fewer sex combs form on the second leg of Scr^Msc, Df(3R)P14/+ flies or Scr^Msc, Df(3R)Exel6178/+ flies.

Scr^Msc flies that are also heterozygous for Df(3R)BSC509, Df(3R)PP2A-B'-CG7208, PP2A-B'^Δ or other deletions removing genes encoding other PP2A regulatory subunits do not have fewer sex combs on the second leg than Scr^Msc mutants alone.

(Moazzen et al., 2009)

The average number of ectopic sex comb teeth on the second and third legs in Scr^Msc heterozygous males is not affected if they are also carrying z¹ or z^a.

(Southworth and Kennison, 2002)

The penetrance of the Scr^Msc/+ extra sex comb phenotype is strongly reduced by M(3)80¹ at 29^oC but not at 22^oC. The penetrance of the phenotype is also reduced by M(2)56F^unspecified or Df(3L)M(3)LS4.

(Sinclair et al., 1984)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

2186

In(3R)Scr^Msc, ru¹ Scr^Msc pum^Msc ss¹ e^s/TM3, Ser¹

Kyoto

106733

In(3R)Scr^Msc, ru¹ Scr^Msc pum^Msc ss¹ e^s/TM3, Ser¹

101711

ru¹ hry¹ Diap1^th-1 st¹ Pc¹² Scr^Msc sr¹ e^s ca¹ / TM3, Sb¹ Ser¹

101893

Antp^XMI Scr^Msc / TM3, y⁺ kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s Ser¹ ; T(Y;3)MA9, ru¹ st¹ e¹ ca¹

Notes on Origin

Discoverer

Tokunaga.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Msc

(Kaufman et al., 1990, Kennison and Russell, 1987, Dura et al., 1985, Sinclair et al., 1984, Hazelrigg and Kaufman, 1983, Duncan, 1982, Kaufman et al., 1980, Lewis et al., 1980, Duncan and Kaufman, 1975)

Msc¹

(LeMotte et al., 1989, Kennison and Russell, 1987, Riley et al., 1987, Scott et al., 1983)

Scr^Msc1

(Pattatucci et al., 1991)

Scr^Msc

(Moazzen et al., 2009, Diop et al., 2008)

Name Synonyms

Multiple sex comb

Secondary FlyBase IDs

References (23)

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