FlyBase Allele Report: Dmel\z[a]

General Information

Symbol

Dmel\z^a

Species

D. melanogaster

Name

FlyBase ID

FBal0018834

Feature type

allele

Associated gene

Dmel\z

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Judd, 1995, Tearle, 1991)

hypomorphic allele - genetic evidence

(Simonelig et al., 1996, Geyer et al., 1990)

loss of function allele

(Lloyd et al., 2002, Muller et al., 1999, Hagstrom et al., 1997, Pal-Bhadra et al., 1997)

Mutagen

X ray

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Pattatucci and Kaufman, 1991)

Description

No detectable rearrangements except for a DNA insertion (about 15 kb) of unknown significance (Gunaratne, Mansukhani, Lipari, Liou, Martindale and Goldberg, 1986).

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Judd, 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

z^a has no effect on female sexual receptivity.

(Juni and Yamamoto, 2009)

Eye colour: yellow, in z^a/z¹ female. Eye colour: essentially wild type, slightly diluted red, in hemizygous male and homozygous female.

(Judd, 1995)

Affects ommochrome pigmentation in the eyes only.

(Tearle, 1991)

Eye colour: diluted, becomes brown with age, in hemizygous male and homozygous female.

(Pirrotta et al., 1987)

Eye colour: wild-type, in hemizygous male and homozygous female.

(Kalisch and Rasmuson, 1974)

Eye colour: nearly wild-type, in hemizygous male and homozygous female.

(Gans, 1953)

Eye colour: wild-type, as z^a/Y male, z⁺/z^a and z^a/z^a female. Eye colour: zeste, as z¹/z^a female. Eye colour: light brown, as z^a w^DZL/z^a w^ch female.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

z^a is an enhancer of visible phenotype of ap^UGO35/Df(2R)DG

(Gohl et al., 2008)

z^a is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

z^a is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

z^a is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

z^a is an enhancer of visible | dominant phenotype of sna^Sco

(Fuse et al., 1999)

NOT Enhancer of

Statement

Reference

z^a is a non-enhancer of visible phenotype of ap^UGO35/Df(2R)DG

(Gohl et al., 2008)

z^a is a non-enhancer of visible phenotype of vg^83b27/vg¹

(Coulthard et al., 2005)

Suppressor of

Statement

Reference

z[+]/z^a is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

z[+]/z^a is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

NOT Suppressor of

Statement

Reference

z^a is a non-suppressor of abnormal courtship behavior | recessive | female phenotype of mbl^chst

(Juni and Yamamoto, 2009)

z^a is a non-suppressor of visible phenotype of ap^56f/Df(2R)DG

(Gohl et al., 2008)

z^a is a non-suppressor of visible phenotype of vg^83b27/vg¹

(Coulthard et al., 2005)

Other

Statement

Reference

mbl^chst/mbl^chst-exC3, z^a has abnormal courtship behavior | female phenotype

(Juni and Yamamoto, 2009)

mbl^chst/mbl^chst-exC45, z^a has abnormal courtship behavior | female phenotype

(Juni and Yamamoto, 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

z^a is an enhancer of wing phenotype of ap^UGO35/Df(2R)DG

(Gohl et al., 2008)

z^a is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

z^a is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

z^a is an enhancer of macrochaeta phenotype of sna^Sco

(Fuse et al., 1999)

NOT Enhancer of

Statement

Reference

z^a is a non-enhancer of wing phenotype of ap^UGO35/Df(2R)DG

(Gohl et al., 2008)

z^a is a non-enhancer of wing phenotype of vg^83b27/vg¹

(Coulthard et al., 2005)

z^a is a non-enhancer of sex comb phenotype of Scr^Wrv4/Scr^Tpl9

(Southworth and Kennison, 2002)

z^a is a non-enhancer of sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

z^a is a non-enhancer of sex comb phenotype of Scr^Antp-A41/Scr^Tpl9

(Southworth and Kennison, 2002)

z^a is a non-enhancer of sex comb phenotype of Scr^Tpl9

(Southworth and Kennison, 2002)

Suppressor of

Statement

Reference

z[+]/z^a is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

z[+]/z^a is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

NOT Suppressor of

Statement

Reference

z^a is a non-suppressor of wing phenotype of ap^56f/Df(2R)DG

(Gohl et al., 2008)

z^a is a non-suppressor of wing phenotype of vg^83b27/vg¹

(Coulthard et al., 2005)

z^a is a non-suppressor of sex comb phenotype of Scr^Wrv4/Scr^Tpl9

(Southworth and Kennison, 2002)

z^a is a non-suppressor of sex comb phenotype of Scr^Antp-A41/Scr^Tpl9

(Southworth and Kennison, 2002)

z^a is a non-suppressor of sex comb phenotype of Scr^Tpl9

(Southworth and Kennison, 2002)

z^a is a non-suppressor of sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of z^a.

(Morimoto et al., 2016)

z^a ; mbl^chst-exC3/mbl^chst and z^a ; mbl^chst-exC45/mbl^chst females show reduced sexual receptivity compared to controls.

(Juni and Yamamoto, 2009)

z^a slightly enhances the mild wing phenotypes in ap^UGO35/Df(2R)DG mutant flies.

z^a does not suppress the wing phenotypes seen in ap^56f/Df(2R)DG mutant flies.

(Gohl et al., 2008)

z^a has no effect on the complementation seen between vg¹ and vg^83b27.

(Coulthard et al., 2005)

g^53d, z^a double mutants have a reduced amount of red pigment in the eye comparted to g^53d single mutants in both male and female flies. The same is true for g^50e and g² alleles.

(Lloyd et al., 2002)

The average number of sex comb teeth per first leg in Scr^Tpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z^a. The average number of sex comb teeth per first leg in Scr^Tpl9/Scr^Antp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z^a. The viability and average number of sex comb teeth per first leg in Scr^Tpl9/Scr^Wrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z^a. The average number of ectopic sex comb teeth on the second and third legs in Scr^Msc heterozygous males is not affected if they are also carrying z^a.

(Southworth and Kennison, 2002)

Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.

(Fuse et al., 1999)

Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen in w^Mcp.y.scs'.1 combined with y^we.Mcp.2, leading to lighter eyes.

(Muller et al., 1999)

Eye colour: brown, as z^a par^X1122 heterozygote. Eye colour: white, z^a par^X1122 w^a heterozygote.

(Thierry-Mieg, 1982)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of z^a.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

1496

y¹ z^a

1059

y¹ z^a w^11E4

183

y¹ z^a w^ch2/C(1)DX, y¹ f¹

Kyoto

101275

z^a

109185

y¹ z^a; mbl^chst-exC3 / CyO

Notes on Origin

Discoverer

Gans.

Comments

Enhances certain genotypes in the bithorax complex and dpp that show transvection.

The sensitivity of the metanotal transformation of the Ubx^unspecified/Ubx^bx-34e genotype to chromosomal rearrangements has been studied in the presence and absence of z^a.

(Babu and Bhat, 1981)

The phenotype of Abd-B^iab7-MX2/Abd-B^iab8-D14 is unaffected by alleles of z.

(Hendrickson and Sakonju, 1995)

Does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

z^a; Ubx^Cbx-1/+ do not differ from Ubx^Cbx-1/+, whereas the wings of z^a; Ubx^1:Cbx-1/+ are considerably less haltere-like than those of Ubx^1:Cbx-1/+. Suppresses transactivation of the wild type Ubx gene by its Ubx^Cbx-1 homologue.

(Goldsborough and Kornberg, 1996)

Introduction of z^a reduces the expression of single copies of w in pairing-sensitive and pairing-insensitive lines. Eye colour of flies carrying two copies of the pairing-sensitive iab-7 PRE lines becomes darker in combination with z^a : suppression of iab-7 PRE silencing.

(Hagstrom et al., 1997)

Does not affect the "co-suppression" seen in flies carrying increasing numbers of the P{Adh^w.PR} transgene.

(Pal-Bhadra et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

z^a

(King et al., 2019, Johnston and Desplan, 2014, Brown and Kassis, 2013, Mellert and Truman, 2012, Juni and Yamamoto, 2009, Kostyuchenko et al., 2009, Gohl et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (42)

Report Sections

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