FlyBase Allele Report: Dmel\osa[1]

General Information

Symbol

Dmel\osa¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013298

Feature type

allele

Associated gene

Dmel\osa

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle | germline clone

(Vazquez et al., 1999)

embryonic epidermis | germline clone

(Vazquez et al., 1999)

embryonic segment | germline clone

(Vazquez et al., 1999)

wing

(Monribot-Villanueva et al., 2013, Gutierrez et al., 2003)

Detailed Description

Statement

Reference

osa¹/+ flies show a slight held-out wing phenotype.

(Monribot-Villanueva et al., 2013)

osa¹/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-31. osa¹/+ has no effect on the telomeric position effect (TPE) of P{wA}4-4.

(Boivin et al., 2003)

3% of heterozygous flies have a held-out wings phenotype.

(Gutierrez et al., 2003)

Heterozygotes do not have a held-out wing phenotype.

(Calgaro et al., 2002)

osa¹/osa² embryos (lacking zygotic osa function) die late in embryogenesis with no clear defects in segmentation or segment identity. Embryos derived from homozygous female germline clones without paternal rescue (lacking both maternal and zygotic osa function) do not differentiate any cuticle. Embryos derived from homozygous female germline clones with paternal rescue (lacking maternal osa function) secrete cuticle but have severe defects in segmentation, resembling gap gene mutants.

(Vazquez et al., 1999)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

osa¹ has visible | dominant phenotype, enhanceable by Sumo⁰⁴⁴⁹³/smt3[+]

(Monribot-Villanueva et al., 2013)

osa¹ has visible | dominant phenotype, enhanceable by tna¹

(Gutierrez et al., 2003)

osa¹ has visible | dominant phenotype, enhanceable by tara²

(Gutierrez et al., 2003)

osa¹ has visible | dominant phenotype, enhanceable by brm²

(Gutierrez et al., 2003)

osa¹ has visible | dominant phenotype, enhanceable by tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

osa¹ has visible | dominant phenotype, enhanceable by tara²⁰

(Gutierrez et al., 2003)

NOT Enhanced by

Statement

Reference

osa¹ has visible | dominant phenotype, non-enhanceable by tna^S058302

(Gutierrez et al., 2003)

Enhancer of

Statement

Reference

osa¹/osa[+] is an enhancer of visible | dominant phenotype of tna¹

(Monribot-Villanueva et al., 2013)

osa¹ is an enhancer of visible | dominant phenotype of brm²

(Gutierrez et al., 2003)

osa¹ is an enhancer of visible | dominant phenotype of tna¹

(Gutierrez et al., 2003)

osa¹ is an enhancer of visible | dominant phenotype of tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

Suppressor of

Statement

Reference

osa¹/osa[+] is a suppressor of visible | dominant | homeotic phenotype of Antp^Ns

(Vazquez et al., 1999)

osa¹/osa[+] is a suppressor of visible | homeotic phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

osa¹ is a non-suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

γTub23C^Pl-2, brm[+]/brm², osa¹/osa[+] has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa¹ has visible | dominant phenotype

(Vázquez et al., 2008)

osa¹, tara¹ has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara^L4 has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara¹/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara^L4/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

brm², osa¹ has visible | dominant phenotype

(Vazquez et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

osa¹ has wing phenotype, enhanceable by Sumo⁰⁴⁴⁹³/smt3[+]

(Monribot-Villanueva et al., 2013)

osa¹ has wing phenotype, enhanceable by tna¹

(Gutierrez et al., 2003)

osa¹ has wing phenotype, enhanceable by tara²

(Gutierrez et al., 2003)

osa¹ has wing phenotype, enhanceable by brm²

(Gutierrez et al., 2003)

osa¹ has wing phenotype, enhanceable by tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

osa¹ has wing phenotype, enhanceable by tara²⁰

(Gutierrez et al., 2003)

NOT Enhanced by

Statement

Reference

osa¹ has wing phenotype, non-enhanceable by tna^S058302

(Gutierrez et al., 2003)

Enhancer of

Statement

Reference

osa¹/osa[+] is an enhancer of wing phenotype of tna¹

(Monribot-Villanueva et al., 2013)

osa¹ is an enhancer of wing phenotype of brm²

(Gutierrez et al., 2003)

osa¹ is an enhancer of wing phenotype of tna¹

(Gutierrez et al., 2003)

osa¹ is an enhancer of wing phenotype of tara⁰³⁸⁸¹

(Gutierrez et al., 2003)

Suppressor of

Statement

Reference

osa¹/osa[+] is a suppressor of antenna phenotype of Antp^Ns

(Vazquez et al., 1999)

osa¹/osa[+] is a suppressor of leg | ectopic phenotype of Antp^Ns

(Vazquez et al., 1999)

osa¹/osa[+] is a suppressor of antenna phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

osa¹ is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

Other

Statement

Reference

γTub23C^Pl-2, brm[+]/brm², osa¹/osa[+] has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa¹ has wing phenotype

(Vázquez et al., 2008)

osa¹, tara¹ has wing phenotype

(Calgaro et al., 2002)

osa¹, tara^L4 has wing phenotype

(Calgaro et al., 2002)

osa¹, tara¹/tara[+] has wing phenotype

(Calgaro et al., 2002)

osa¹, tara^L4/tara[+] has wing phenotype

(Calgaro et al., 2002)

brm², osa¹ has wing phenotype

(Vazquez et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Trans-heterozygous tna¹, osa¹ double mutants show a stronger held-out wing phenotype than either of the single mutants.

smt3⁰⁴⁴⁹³/+ augments the penetrance and the expressivity of the weak held-out wing phenotype of osa¹/+.

(Monribot-Villanueva et al., 2013)

γTub23C^Pl-2 results in a held-out wing phenotype in double heterozygous combination with osa¹ (98% penetrance).

γTub23C^Pl-2/+ ; brm²/osa¹ triple heterozygous flies show poor survival and have twisted and blistered wings.

(Vázquez et al., 2008)

100% of brm²/osa¹ flies have a held-out wings phenotype. 100% of tna¹/osa¹ flies have a held-out wings phenotype. tna^S058302/osa¹ flies do not have a held-out wings phenotype. 72% of osa¹/tara² flies have a held-out wings phenotype. 75% of osa¹/tara²⁰ flies have a held-out wings phenotype. 31% of osa¹/tara⁰³⁸⁸¹ flies have a held-out wings phenotype.

(Gutierrez et al., 2003)

36% of osa¹ tara^L4 double heterozygotes have a held-out wing phenotype. 28% of osa¹ tara¹ double heterozygotes have a held-out wing phenotype.

(Calgaro et al., 2002)

brm² osa¹ double heterozygotes have held-out wings. This phenotype is partially suppressed if the flies are also carrying brm^+t14.4. Antp^73b/+ flies show transformation of antenna to leg. This phenotype is not suppressed by one copy of osa¹. Antp^Ns/+ flies show transformation of antenna to leg. This phenotype is significantly suppressed by one copy of osa¹. Expression of Antp^hs.PHTA during the larval stages results in antenna to leg transformations. This phenotype is not affected if the animals are also carrying osa¹.

(Vazquez et al., 1999)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is not suppressed by osa¹.

(Maixner et al., 1998)

Suppresses the antenna to leg transformation phenotype of Pc², Antp^Ns/+. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

osa^Arv1

(Talbert and Garber, 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

osa¹

(Monribot-Villanueva et al., 2013, Di Stefano et al., 2011, Vázquez et al., 2008, Chang et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (18)

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