FlyBase Allele Report: Dmel\tara[L4]

General Information

Symbol

Dmel\tara^L4

Species

D. melanogaster

Name

FlyBase ID

FBal0135608

Feature type

allele

Associated gene

Dmel\tara

Associated Insertion(s)

P{lacW}tara^L4

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Calgaro et al., 2002)

Mutagen

Delta2-3 transposase

(Calgaro et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{lacW}tara^L4

Cytology

Description

P{lacW} insertion in an intron.

(Calgaro et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3R)sbd26)

(Calgaro et al., 2002)

lethal (with tara^R19)

(Calgaro et al., 2002)

lethal (with tara^R38)

(Calgaro et al., 2002)

lethal (with tara^R40)

(Calgaro et al., 2002)

lethal (with tara^R47)

(Calgaro et al., 2002)

lethal (with tara^R58)

(Calgaro et al., 2002)

lethal (with tara^R75)

(Calgaro et al., 2002)

lethal (with tara^R91)

(Calgaro et al., 2002)

lethal (with tara^R108)

(Calgaro et al., 2002)

lethal | recessive

(Calgaro et al., 2002)

visible, with tara^β.Ubi-p63E

(Calgaro et al., 2002)

Phenotype Manifest In

arista, with tara^β.Ubi-p63E

(Calgaro et al., 2002)

haltere, with tara^β.Ubi-p63E

(Calgaro et al., 2002)

wing, with tara^β.Ubi-p63E

(Calgaro et al., 2002)

Detailed Description

Statement

Reference

Homozygotes and tara^L4/Df(3R)sbd26 animals die as late embryos or first instar larvae without any obvious cuticle pattern defects. Heterozygotes do not have a held-out wing phenotype. tara^L4 homozygotes rescued by one copy of tara^β.Ubi-p63E have poor fertility and a fully penetrant wings-held-out phenotype. tara^L4 homozygotes rescued by a single copy of tara^β.Ubi-p63E sometimes have a thickened arista (resembling a weak antenna-to-leg transformation) and they may have haltere defects, which appear to be result from transformation to wing margin (a row of bristles is formed). Only 30% of tara^L4 homozygotes rescued by two copies of tara^β.Ubi-p63E have a held-out wings phenotype and their fertility is increased compared to those carrying one copy of tara^β.Ubi-p63E.

(Calgaro et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

brm[+]/brm², tara^L4 has visible | dominant phenotype, enhanceable by trx[+]/trx^E2

(Calgaro et al., 2002)

Suppressor of

Statement

Reference

tara^L4 is a suppressor of visible | dominant | homeotic phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara^L4 is a suppressor of visible | dominant | homeotic phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

Other

Statement

Reference

brm², tara^L4/tara[+], trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm², tara^L4 has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara^L4 has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara^L4/tara[+], trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm², tara^L4/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara^L4/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

pb^hs.PB, tara^L4 has visible | dominant phenotype

(Calgaro et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

brm[+]/brm², tara^L4 has wing phenotype, enhanceable by trx[+]/trx^E2

(Calgaro et al., 2002)

Suppressor of

Statement

Reference

tara^L4 is a suppressor of mesothoracic leg phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara^L4 is a suppressor of metathoracic leg phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara^L4 is a suppressor of sex comb | ectopic phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara^L4 is a suppressor of mesothoracic leg phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara^L4 is a suppressor of metathoracic leg phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara^L4 is a suppressor of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

NOT Suppressor of

Statement

Reference

tara^L4/tara[+] is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

brm², tara^L4/tara[+], trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², tara^L4 has wing phenotype

(Calgaro et al., 2002)

osa¹, tara^L4 has wing phenotype

(Calgaro et al., 2002)

pb⁴/pb¹³, tara^L4 has labellum | distal phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara^L4/tara[+], trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², tara^L4/tara[+] has wing phenotype

(Calgaro et al., 2002)

pb⁴/pb¹³, tara^L4/tara[+] has labellum | distal phenotype

(Calgaro et al., 2002)

pb⁴/pb¹³, tara^L4/tara[+] has arista | ectopic phenotype

(Calgaro et al., 2002)

pb⁴/pb¹³, tara^L4 has arista | ectopic phenotype

(Calgaro et al., 2002)

osa¹, tara^L4/tara[+] has wing phenotype

(Calgaro et al., 2002)

pb^hs.PB, tara^L4 has wing vein L5 phenotype

(Calgaro et al., 2002)

pb^hs.PB, tara^L4 has wing vein L4 phenotype

(Calgaro et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

60% of flies carrying pb^hs.PB that are also heterozygous for tara^L4 show partial truncation of the distal part of wing vein L4. This phenotype is not seen in either pb^hs.PB single mutant or tara^L4/+ single mutant flies. Deletions of wing vein L5 are also seen in the double mutant flies. pb⁴ tara^L4/pb¹³ + flies show a weak but reliable transformation of the distal labium to antennal arista. 36% of osa¹ tara^L4 double heterozygotes have a held-out wing phenotype. 2% of trx^E2 tara^L4 double heterozygotes have a held-out wing phenotype. 12% of brm² tara^L4 double heterozygotes have a held-out wing phenotype. 45% of trx^E2 brm² tara^L4 triple heterozygotes have a held-out wing phenotype.

(Calgaro et al., 2002)

tara^L4/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

tara^L4 is partially rescued by tara^β.Ubi-p63E

(Calgaro et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The recessive lethality of tara^L4 and its interaction with pb^hs.PB can be reverted by excision of the P{lacW} element.

(Calgaro et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tara^L4

Name Synonyms

Secondary FlyBase IDs

References (2)

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