FB2025_04 , released October 2, 2025
Allele: Dmel\pb13
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General Information
Symbol
Dmel\pb13
Species
D. melanogaster
Name
FlyBase ID
FBal0013517
Feature type
allele
Associated gene
Dmel\pb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cribbs et al., 1992)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: C655S.

(Tayyab et al., 2004)

Nucleotide substitution: T1344C.

(Tayyab et al., 2004)

Nucleotide substitution: C1964C.

(Tayyab et al., 2004)

Amino acid replacement: Q736term.

(Tayyab et al., 2004)

Nucleotide substitution: C2206T.

(Tayyab et al., 2004)

The nucleotide substitution C2206T results in a premature stop codon at residue 736. The mutant allele also contains the nucleotide polymorphism G1964C, which results in a C655S protein polymorphism and the silent nucleotide polymorphism T1344C (coordinates of the lesions are the position in the 2-μ-4a spliced form of pb).

(Tayyab et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,708,351..6,708,351 [-]
Nucleotide change:

C6708351T

Reported nucleotide change:

C2206T

Amino acid change:

Q736term | pb-PA; Q731term | pb-PB; Q731term | pb-PC; Q726term | pb-PD

Reported amino acid change:

Q736term

Comment:

The C655S polymorphism is also present in this strain. Reported coordinates are with respect to pb-RA and pb-PA.

(Tayyab et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pb13/pb20 flies show a reduction in length of the maxillary palps, the labellar cap is weakly transformed towards an arista and the number of pseudotracheal rows is reduced to 3 or 4.

      (Tayyab et al., 2004)

      pb4/pb13 flies have nearly normal labial palps, which show a slight reduction of the pseudotracheal rows.

      (Calgaro et al., 2002)

      pb5/pb13 flies show a slight distal transformation of labium to antennal arista. If the flies are also heterozygous for N55e11 the number of pseudotracheal rows is reduced and a region of apparent ectoderm forms between the remaining pseudotracheal rows and the transformed antennal structures.

      (Boube et al., 1998)

      The labial palp is transformed weakly to antenna.

      (Cribbs et al., 1992)

      weak antenna

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      pb4/pb13, taraL4 has labellum | distal phenotype

      (Calgaro et al., 2002)

      pb4/pb13, taraL4 has arista | ectopic phenotype

      (Calgaro et al., 2002)

      pb4/pb13, taraL4/tara[+] has labellum | distal phenotype

      (Calgaro et al., 2002)

      pb4/pb13, taraL4/tara[+] has arista | ectopic phenotype

      (Calgaro et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pb4 taraL4/pb13 + flies show a weak but reliable transformation of the distal labium to antennal arista.

      (Calgaro et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Fornili.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      f4
      (Cribbs et al., 1992)
      pb13
      (Tayyab et al., 2004)
      pbf4
      Name Synonyms
      Secondary FlyBase IDs
        References (4)