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General Information
Symbol
Dmel\Pc16
Species
D. melanogaster
Name
FlyBase ID
FBal0013566
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PcK
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

2kb deletion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pc16 mutants exhibit an esc-like phenotype, consisting of homeotic transformation of mesothoracic or metathoracic legs towards prothoracic legs due to the deregulation of Scr. Pc16/+ flies exhibit wing-type wings.

Heterozygous males have ectopic sex comb teeth on the T2 (penetrance 69%) and T3 (penetrance 15%) legs.

Heterozygous males have ectopic sex comb teeth on the mesothoracic legs.

Transformation of second to first leg. Transformation of third to second leg.

Does not affect the position effect variegation (PEV) at the w locus caused by In(1)wm4 or PEV at the B locus caused by Dp(1;Y)BSCV.

Mutation changes the level of w expression in ph-plac+3 flies; eye colour is darker.

Phenoytpe manifest in: mesothoracic leg Shows a mesothoracic leg to prothoracic leg transformation.

Partial transformations of second and third legs into first legs in Pc/+ heterozygotes.

Shows a recessive extra sex comb phenotype. Enhances the extra sex combs phenotype of Pc2, AntpNs/+. Causes between a two- and four-fold enhancement of the extra sex combs phenotype of Pc4/+.

Enhances extra sex combs phenotype of Pc4.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Pc16 has visible | recessive phenotype, enhanceable by lolalk02512

Pc16 has visible | dominant phenotype, enhanceable by eff[+]/effmer4

Pc16 has visible | homeotic phenotype, enhanceable by dom14/dom[+]

Pc16 has visible phenotype, enhanceable by corto420

Pc16 has visible | dominant phenotype, enhanceable by effmer1/eff[+]

Suppressed by
Statement
Reference

Pc16 has visible | recessive | homeotic phenotype, suppressible by lolal311a

Pc16 has visible | recessive | homeotic phenotype, suppressible by lolalk07907

Pc16 has visible | recessive | homeotic phenotype, suppressible by lolalk11212

Pc16 has visible | recessive | homeotic phenotype, suppressible by lolal+tBB

Pc16 has visible | dominant | homeotic phenotype, suppressible by tara1

Pc16 has visible | dominant | homeotic phenotype, suppressible by taraL4

Pc16 has visible | dominant phenotype, suppressible by tou[+]/tou1

Pc16 has visible | dominant phenotype, suppressible by tara1/tara[+]

Pc16 has visible phenotype, suppressible by Su(Pc)35CDT41.2/Su(Pc)35CD[+]

Enhancer of
Statement
Reference

Pc16/Pc[+] is an enhancer of visible | recessive | homeotic phenotype of mxcM1

Suppressor of
Statement
Reference

Pc16 is a suppressor of abnormal eye color phenotype of wT81

Phenotype Manifest In
Enhanced by
Statement
Reference

Pc16 has sex comb tooth phenotype, enhanceable by lolalk02512

Pc16 has mesothoracic leg phenotype, enhanceable by eff[+]/effmer4

Pc16 has sex comb | ectopic phenotype, enhanceable by eff[+]/effmer4

Pc16 has mesothoracic leg phenotype, enhanceable by dom14/dom[+]

Pc16 has metathoracic leg phenotype, enhanceable by dom14/dom[+]

Pc16 has sex comb phenotype, enhanceable by corto420

Pc16 has phenotype, enhanceable by mxcM1

Pc16 has sex comb | ectopic phenotype, enhanceable by E(z)+t8.8

Pc16 has sex comb phenotype, enhanceable by Df(2R)CA53

Pc16 has leg phenotype, enhanceable by Df(3L)fz-GF3b

Pc16 has sex comb phenotype, enhanceable by Df(3L)fz-GF3b

Pc16 has leg phenotype, enhanceable by Df(3L)fz-GS1a

Pc16 has sex comb phenotype, enhanceable by Df(3L)fz-GS1a

Pc16 has leg phenotype, enhanceable by salm1

Pc16 has sex comb phenotype, enhanceable by salm1

Pc16 has leg phenotype, enhanceable by Df(2R)trix

Pc16 has sex comb phenotype, enhanceable by Df(2R)trix

Pc16 has leg phenotype, enhanceable by Df(2R)CA53

Pc16 has mesothoracic leg phenotype, enhanceable by effmer1/eff[+]

NOT Enhanced by
Statement
Reference

Pc16 has phenotype, non-enhanceable by Alhunspecified

Suppressed by
Statement
Reference

Pc16 has metathoracic leg phenotype, suppressible by lolal+tBB

Pc16 has prothoracic leg | ectopic phenotype, suppressible by lolal+tBB

Pc16 has sex comb tooth phenotype, suppressible by lolal+tBB

Pc16 has mesothoracic leg phenotype, suppressible by lolal311a

Pc16 has metathoracic leg phenotype, suppressible by lolal311a

Pc16 has prothoracic leg | ectopic phenotype, suppressible by lolal311a

Pc16 has mesothoracic leg phenotype, suppressible by lolalk07907

Pc16 has metathoracic leg phenotype, suppressible by lolalk07907

Pc16 has mesothoracic leg phenotype, suppressible by lolalk11212

Pc16 has metathoracic leg phenotype, suppressible by lolalk11212

Pc16 has mesothoracic leg phenotype, suppressible by lolal+tBB

Pc16 has mesothoracic leg phenotype, suppressible by tara1

Pc16 has metathoracic leg phenotype, suppressible by tara1

Pc16 has sex comb | ectopic phenotype, suppressible by tara1

Pc16 has mesothoracic leg phenotype, suppressible by taraL4

Pc16 has metathoracic leg phenotype, suppressible by taraL4

Pc16 has sex comb | ectopic phenotype, suppressible by taraL4

Pc16 has mesothoracic leg phenotype, suppressible by tou[+]/tou1

Pc16 has sex comb | ectopic phenotype, suppressible by tou[+]/tou1

Pc16 has mesothoracic leg phenotype, suppressible by tara1/tara[+]

Pc16 has sex comb | ectopic phenotype, suppressible by tara1/tara[+]

Pc16 has sex comb | ectopic phenotype, suppressible by Pcl+t16.3

Pc16 has leg phenotype, suppressible by Df(2L)H20

Pc16 has sex comb phenotype, suppressible by Df(2L)H20

Pc16 has leg phenotype, suppressible by Df(2L)TW50

Pc16 has sex comb phenotype, suppressible by Df(2L)TW50

Pc16 has leg phenotype, suppressible by Df(2L)pr-A16

Pc16 has sex comb phenotype, suppressible by Df(2L)pr-A16

Pc16 has leg phenotype, suppressible by Df(3L)fz-D21

Pc16 has sex comb phenotype, suppressible by Df(3L)fz-D21

Pc16 has mesothoracic leg phenotype, suppressible by Su(Pc)35CDT41.2/Su(Pc)35CD[+]

NOT suppressed by
Statement
Reference

Pc16 has phenotype, non-suppressible by Alhunspecified

Enhancer of
Statement
Reference

Pc16 is an enhancer of phenotype of mxcM1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

lolalk02512 enhances the Pc16 esc-like phenotype, consisting of homeotic transformation of mesothoracic or metathoracic legs towards prothoracic legs due to the deregulation of Scr. In addition there is an increase in the mean number of sex comb teeth in Pc16, lolalk02512 double mutants. One extra copy of lolal+tBB, lolalScer\UAS.T:Zzzz\FLAG or lolalScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32, suppresses the Pc16 esc-like phenotype. Mutants heterozygous for lolalk02512, lolalk11212, or lolalk07907, when also heterozygous for Pc16, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc, often resulting in curvature of the wing. This phenotype is further enhanced in specific lolal heteroallelic viable combinations, such as lolalk02512/lolal311a, lolalk11212/lolal311a, and lolalk07907/lolal311a, when also heterozygous for Pc16.

Moderate suppressor of eye pigment phenotype of wT81.

Hemizygous mxcM1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxcM1/Y in trans with one mutant copy of Pc16.

The extra sex combs phenotype of Pc16 heterozygotes is dominantly enhanced by salm1, Df(2R)trix, Df(2R)CA53, Df(3L)fz-GF3b and Df(3L)fz-GS1a. The extra sex combs phenotype of Pc16 heterozygotes is dominantly suppressed by Df(2L)H20, Df(2L)TW50, Df(2L)pr-A16 and Df(3L)fz-D21.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

invW/Pc16 wings exhibit a wing phenotype (similar to the gain of function ci phenotype).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (24)