FlyBase Allele Report: Dmel\Pc[16]

General Information

Symbol

Dmel\Pc¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0013566

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Also Known As

Pc^K

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Campbell et al., 1995, Cheng et al., 1994)

Mutagen

ethyl methanesulfonate

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

2kb deletion.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation, with P{418}E(Pc)17B^T2.2.31

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}I7.1

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}I33.1

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T3

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T13.4

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T13.5

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T26

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T30

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T33.1.2

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T33.1.24j

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T40

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T42.1

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T43

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{418}T72.1

(Fauvarque and Dura, 1993)

enhancer of variegation, with P{419}6.1

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}e(Pc)84DE^T66.1

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}I2.1.2

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T15.2

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T33.1.5

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T44

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T53.3

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T63

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T69.3

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T72.2

(Fauvarque and Dura, 1993)

visible

(Kodjabachian et al., 1998)

visible | dominant

(Fauvarque et al., 2001, Fauvarque and Dura, 1993)

visible | dominant | homeotic

(Calgaro et al., 2002, Ruhf et al., 2001)

visible | homeotic

(Faucheux et al., 2003)

visible | recessive

(Faucheux et al., 2003, Kennison and Tamkun, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

Pc¹⁶ mutants exhibit an esc-like phenotype, consisting of homeotic transformation of mesothoracic or metathoracic legs towards prothoracic legs due to the deregulation of Scr. Pc¹⁶/+ flies exhibit wing-type wings.

(Faucheux et al., 2003)

Heterozygous males have ectopic sex comb teeth on the T2 (penetrance 69%) and T3 (penetrance 15%) legs.

(Calgaro et al., 2002)

Heterozygous males have ectopic sex comb teeth on the mesothoracic legs.

(Fauvarque et al., 2001)

Transformation of second to first leg. Transformation of third to second leg.

(Ruhf et al., 2001)

Does not affect the position effect variegation (PEV) at the w locus caused by In(1)w^m4 or PEV at the B locus caused by Dp(1;Y)B^SCV.

(Sinclair et al., 1998)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker.

(Fauvarque et al., 1995)

Phenoytpe manifest in: mesothoracic leg Shows a mesothoracic leg to prothoracic leg transformation.

(Fauvarque and Dura, 1993)

Partial transformations of second and third legs into first legs in Pc/+ heterozygotes.

(Lindsley and Zimm, 1992)

Shows a recessive extra sex comb phenotype. Enhances the extra sex combs phenotype of Pc², Antp^Ns/+. Causes between a two- and four-fold enhancement of the extra sex combs phenotype of Pc⁴/+.

(Kennison and Tamkun, 1988)

Enhances extra sex combs phenotype of Pc⁴.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pc¹⁶ has visible | recessive phenotype, enhanceable by lolal^k02512

(Faucheux et al., 2003)

Pc¹⁶ has visible | dominant phenotype, enhanceable by eff[+]/eff^mer4

(Fauvarque et al., 2001)

Pc¹⁶ has visible | homeotic phenotype, enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Pc¹⁶ has visible phenotype, enhanceable by corto⁴²⁰

(Kodjabachian et al., 1998)

Pc¹⁶ has visible | dominant phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

Suppressed by

Statement

Reference

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by lolal^+tBB

(Faucheux et al., 2003)

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by lolal^311a

(Faucheux et al., 2003)

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by lolal^k07907

(Faucheux et al., 2003)

Pc¹⁶ has visible | recessive | homeotic phenotype, suppressible by lolal^k11212

(Faucheux et al., 2003)

Pc¹⁶ has visible | dominant | homeotic phenotype, suppressible by tara¹

(Calgaro et al., 2002)

Pc¹⁶ has visible | dominant | homeotic phenotype, suppressible by tara^L4

(Calgaro et al., 2002)

Pc¹⁶ has visible | dominant phenotype, suppressible by tou[+]/tou¹

(Fauvarque et al., 2001)

Pc¹⁶ has visible | dominant phenotype, suppressible by tara¹/tara[+]

(Fauvarque et al., 2001)

Pc¹⁶ has visible phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

Enhancer of

Statement

Reference

Pc¹⁶/Pc[+] is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

Suppressor of

Statement

Reference

Pc¹⁶ is a suppressor of abnormal eye color phenotype of w^T81

(Netter et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc¹⁶ has mesothoracic leg phenotype, enhanceable by lolal^k02512

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, enhanceable by lolal^k02512

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, enhanceable by lolal^k02512

(Faucheux et al., 2003)

Pc¹⁶ has sex comb tooth phenotype, enhanceable by lolal^k02512

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, enhanceable by eff[+]/eff^mer4

(Fauvarque et al., 2001)

Pc¹⁶ has sex comb | ectopic phenotype, enhanceable by eff[+]/eff^mer4

(Fauvarque et al., 2001)

Pc¹⁶ has mesothoracic leg phenotype, enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Pc¹⁶ has metathoracic leg phenotype, enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Pc¹⁶ has sex comb phenotype, enhanceable by corto⁴²⁰

(Kodjabachian et al., 1998)

Pc¹⁶ has phenotype, enhanceable by mxc^M1

(Docquier et al., 1996)

Pc¹⁶ has sex comb | ectopic phenotype, enhanceable by E(z)^+t8.8

(Campbell et al., 1995)

Pc¹⁶ has sex comb phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, enhanceable by Df(3L)fz-GS1a

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, enhanceable by Df(3L)fz-GS1a

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, enhanceable by salm¹

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, enhanceable by salm¹

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, enhanceable by Df(2R)trix

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, enhanceable by Df(2R)trix

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

Pc¹⁶ has mesothoracic leg phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

NOT Enhanced by

Statement

Reference

Pc¹⁶ has phenotype, non-enhanceable by Alh^unspecified

(Perrin et al., 2003)

Suppressed by

Statement

Reference

Pc¹⁶ has mesothoracic leg phenotype, suppressible by lolal^+tBB

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by lolal^311a

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by lolal^k07907

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by lolal^k11212

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by lolal^+tBB

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by lolal^311a

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by lolal^k07907

(Faucheux et al., 2003)

Pc¹⁶ has metathoracic leg phenotype, suppressible by lolal^k11212

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by lolal^+tBB

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by lolal^311a

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by lolal^k07907

(Faucheux et al., 2003)

Pc¹⁶ has prothoracic leg | ectopic phenotype, suppressible by lolal^k11212

(Faucheux et al., 2003)

Pc¹⁶ has sex comb tooth phenotype, suppressible by lolal^+tBB

(Faucheux et al., 2003)

Pc¹⁶ has sex comb tooth phenotype, suppressible by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

Pc¹⁶ has sex comb tooth phenotype, suppressible by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by tara¹

(Calgaro et al., 2002)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by tara^L4

(Calgaro et al., 2002)

Pc¹⁶ has metathoracic leg phenotype, suppressible by tara¹

(Calgaro et al., 2002)

Pc¹⁶ has metathoracic leg phenotype, suppressible by tara^L4

(Calgaro et al., 2002)

Pc¹⁶ has sex comb | ectopic phenotype, suppressible by tara¹

(Calgaro et al., 2002)

Pc¹⁶ has sex comb | ectopic phenotype, suppressible by tara^L4

(Calgaro et al., 2002)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by tara¹/tara[+]

(Fauvarque et al., 2001)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by tou[+]/tou¹

(Fauvarque et al., 2001)

Pc¹⁶ has sex comb | ectopic phenotype, suppressible by tara¹/tara[+]

(Fauvarque et al., 2001)

Pc¹⁶ has sex comb | ectopic phenotype, suppressible by tou[+]/tou¹

(Fauvarque et al., 2001)

Pc¹⁶ has sex comb | ectopic phenotype, suppressible by Pcl^+t16.3

(Campbell et al., 1995)

Pc¹⁶ has leg phenotype, suppressible by Df(2L)H20

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, suppressible by Df(2L)H20

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, suppressible by Df(2L)TW50

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, suppressible by Df(2L)TW50

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, suppressible by Df(2L)pr-A16

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, suppressible by Df(2L)pr-A16

(Landecker et al., 1994)

Pc¹⁶ has leg phenotype, suppressible by Df(3L)fz-D21

(Landecker et al., 1994)

Pc¹⁶ has sex comb phenotype, suppressible by Df(3L)fz-D21

(Landecker et al., 1994)

Pc¹⁶ has mesothoracic leg phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

NOT suppressed by

Statement

Reference

Pc¹⁶ has phenotype, non-suppressible by Alh^unspecified

(Perrin et al., 2003)

Enhancer of

Statement

Reference

Pc¹⁶ is an enhancer of phenotype of mxc^M1

(Docquier et al., 1996)

Other

Statement

Reference

Pc¹⁶, inv^W has wing phenotype

(Randsholt et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

lolal^k02512 enhances the Pc¹⁶ esc-like phenotype, consisting of homeotic transformation of mesothoracic or metathoracic legs towards prothoracic legs due to the deregulation of Scr. In addition there is an increase in the mean number of sex comb teeth in Pc¹⁶, lolal^k02512 double mutants. One extra copy of lolal^+tBB, lolal^{Scer\UAS.T:Zzzz\FLAG} or lolal^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^da.G32, suppresses the Pc¹⁶ esc-like phenotype. Mutants heterozygous for lolal^k02512, lolal^k11212, or lolal^k07907, when also heterozygous for Pc¹⁶, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc, often resulting in curvature of the wing. This phenotype is further enhanced in specific lolal heteroallelic viable combinations, such as lolal^k02512/lolal^311a, lolal^k11212/lolal^311a, and lolal^k07907/lolal^311a, when also heterozygous for Pc¹⁶.

(Faucheux et al., 2003)

Moderate suppressor of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of Pc¹⁶.

(Saget et al., 1998)

The extra sex combs phenotype of Pc¹⁶ heterozygotes is dominantly enhanced by salm¹, Df(2R)trix, Df(2R)CA53, Df(3L)fz-GF3b and Df(3L)fz-GS1a. The extra sex combs phenotype of Pc¹⁶ heterozygotes is dominantly suppressed by Df(2L)H20, Df(2L)TW50, Df(2L)pr-A16 and Df(3L)fz-D21.

(Landecker et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

inv^W/Pc¹⁶ wings exhibit a wing phenotype (similar to the gain of function ci phenotype).

(Randsholt et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Pc¹⁶

Pc^K1

(Kennison and Tamkun, 1988)

Pc^K

(Perrin et al., 2003, Faucheux et al., 2001, Ruhf et al., 2001, Randsholt et al., 2000, Kodjabachian et al., 1998, Fauvarque and Dura, 1993)

Pc^k

(Bloyer et al., 2003, Saget et al., 1998, Docquier et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (24)

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