FlyBase Allele Report: Dmel\γTub23C[Pl-2]

General Information

Symbol

Dmel\γTub23C^Pl-2

Species

D. melanogaster

Name

Pearl-2

FlyBase ID

FBal0190681

Feature type

allele

Associated gene

Dmel\γTub23C

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Vázquez et al., 2008)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: M382I.

(Vázquez et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,974,322..2,974,322 [+]

Nucleotide change:

G2974322H

Amino acid change:

M382I | gammaTub23C-PA

Reported amino acid change:

M382I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vázquez et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2L)3G)

(Vázquez et al., 2008)

lethal (with Df(2L)JS17)

(Vázquez et al., 2008)

lethal (with γTub23C^A6-2)

(Vázquez et al., 2008)

lethal (with γTub23C^A14-9)

(Vázquez et al., 2008)

lethal (with γTub23C^A15-2)

(Vázquez et al., 2008)

lethal (with γTub23C^bmps1)

(Vázquez et al., 2008)

visible | dominant

(Vázquez et al., 2008, Vazquez et al., 2006)

Phenotype Manifest In

eye

(Vázquez et al., 2008, Vazquez et al., 2006)

wing

(Vazquez et al., 2006)

wing blade

(Vázquez et al., 2008, Vazquez et al., 2006)

wing margin

(Vázquez et al., 2008)

wing vein

(Vazquez et al., 2006)

wing vein L2

(Vázquez et al., 2008)

wing vein L3

(Vázquez et al., 2008)

Detailed Description

Statement

Reference

Heterozygotes have pearl-like structures in the wings, which are predominantly found in the L2 and L3 wing veins. In addition, they have blisters in the wing blade, and notches or gaps in the ventral and dorsal margins in one or both wings. The heterozygotes also have small round eyes.

6% of γTub23C^A6-2/γTub23C^Pl-2 animals survive to eclosion, but all quickly become stuck in the food medium.

(Vázquez et al., 2008)

Heterozygotes have small eyes, held-out and notched wings, wing blisters and pearl-like structures in the wing blade and veins.

(Vazquez et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

γTub23C^A6-2/γTub23C^Pl-2 has lethal phenotype, suppressible | partially by Grip91^su(Pl)

(Vázquez et al., 2008)

Df(2L)JS17/γTub23C^Pl-2 has lethal phenotype, suppressible | partially by Grip91^su(Pl)

(Vázquez et al., 2008)

Df(2L)3G/γTub23C^Pl-2 has lethal phenotype, suppressible | partially by Grip91^su(Pl)

(Vázquez et al., 2008)

NOT suppressed by

Statement

Reference

γTub23C^A14-9/γTub23C^Pl-2 has lethal phenotype, non-suppressible by Grip91^su(Pl)

(Vázquez et al., 2008)

γTub23C^bmps1/γTub23C^Pl-2 has lethal phenotype, non-suppressible by Grip91^su(Pl)

(Vázquez et al., 2008)

Enhancer of

Statement

Reference

γTub23C^Pl-2 is an enhancer of visible | dominant phenotype of tna¹

(Vázquez et al., 2008)

Other

Statement

Reference

γTub23C^Pl-2, brm¹ has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa² has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, tara² has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, tara²⁰ has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor⁶ has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, brm[+]/brm², osa¹/osa[+] has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, brm² has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor¹ has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor² has visible | dominant phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa¹ has visible | dominant phenotype

(Vázquez et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

γTub23C^Pl-2 is an enhancer of wing phenotype of tna¹

(Vázquez et al., 2008)

Other

Statement

Reference

γTub23C^Pl-2, brm¹ has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa² has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, tara² has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, tara²⁰ has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor⁶ has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, brm[+]/brm², osa¹/osa[+] has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, brm² has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor¹ has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, mor² has wing phenotype

(Vázquez et al., 2008)

γTub23C^Pl-2, osa¹ has wing phenotype

(Vázquez et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

γTub23C^Pl-2 results in a held-out wing phenotype in double heterozygous combination with a number of mutations (penetrance of the phenotype given in parentheses); brm¹ (35%), brm² (76%), mor¹ (10%), mor² (42%), mor⁶ (19%), osa¹ (98%), osa² (39%), tna¹ (75%), tara² (22%), tara²⁰ (21%).

γTub23C^Pl-2/+ ; brm²/osa¹ triple heterozygous flies show poor survival and have twisted and blistered wings.

(Vázquez et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

γTub23C^bmps1

(Vázquez et al., 2008)

γTub23C^A14-9

(Vázquez et al., 2008)

γTub23C^A15-2

(Vázquez et al., 2008)

γTub23C^A6-2

(Vázquez et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series (in order of decreasing activity): γTub23C^A14-9 > γTub23C^A6-2 > γTub23C^A15-2 = Df(2L)JS17 = Df(2L)3G > γTub23C^Pl-2.

(Vázquez et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Pl²

(Vázquez et al., 2008)

Pl[2]

(Vazquez et al., 2006)

γTub23C²

γTub23C^Pl-2

(Vázquez et al., 2008)

Name Synonyms

Pearl-2

(Vázquez et al., 2008)

Pearl[2]

(Vazquez et al., 2006)

Secondary FlyBase IDs

References (2)

Report Sections

Open Close