FlyBase Allele Report: Dmel\Pc[2]

General Information

Symbol

Dmel\Pc²

Species

D. melanogaster

Name

FlyBase ID

FBal0013552

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Struhl, 1983)

antimorphic allele - genetic evidence

(Muller et al., 1999, Capdevila et al., 1986)

Mutagen

X ray

(Muller et al., 1999, Capdevila et al., 1986)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Capdevila et al., 1986)

lethal - all die during embryonic stage | recessive

(Tiong and Russell, 1990)

some die during embryonic stage | recessive

(Tiong and Russell, 1990)

visible | dominant

(Tiong and Russell, 1990)

Phenotype Manifest In

mesothoracic leg

(Tiong and Russell, 1990)

wing

(Tiong and Russell, 1990)

Detailed Description

Statement

Reference

Heterozygous adults show transformations of 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin. Pc²²/Pc² transheterozygotes survive to the pupal stage, giving pharate adults with a strong Pc adult phenotype: there are intersegmental, wing to haltere, extra sex comb and abdominal homeotic transformations. In addition, there is partial transformation of ventral wing margin to dorsal, and posterior wing to anterior.

(Tiong and Russell, 1990)

Transformation of anterior segments to the 8th abdominal segment. Double heterozygous adult escapers show a mild homeotic transformation.

(Capdevila et al., 1986)

Homozygous esc^unspecified embryos (derived from homozygous esc^unspecified mothers) that are also homozygous for Pc² show a more extreme transformation than those carrying two copies of Pc⁺.

(Struhl, 1983)

partial transformations of second and third legs into first legs in Pc/+ heterozygotes

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Antp^Ns, Pc² has visible | homeotic phenotype, enhanceable by Pcl[+]/Pcl¹⁸

(Kennison and Tamkun, 1988)

Suppressed by

Statement

Reference

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by brm¹/brm[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by mor[+]/mor¹

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by mor²/mor[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa¹/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa²/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa[+]/osa³

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa[+]/osa⁴

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

Other

Statement

Reference

Pc², Scm^ET50 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Pc², Scm^R5-13 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Pc², Scm^Suz302 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Antp^Ns, Pc² has visible | homeotic phenotype

(Kennison and Tamkun, 1988)

Antp⁴⁹, Pc² has partially lethal - majority die | dominant phenotype

(Lindsley and Grell, 1968)

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^Ns, Pc² has antenna phenotype, enhanceable by Pcl[+]/Pcl¹⁸

(Kennison and Tamkun, 1988)

Suppressed by

Statement

Reference

Antp^Ns, Pc² has antenna phenotype, suppressible by mor[+]/mor¹

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by mor²/mor[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa¹/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa²/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa[+]/osa³

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa[+]/osa⁴

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

Antp^Scx, Pc² has sex comb phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by brm¹/brm[+]

(Kennison and Tamkun, 1988)

NOT Enhancer of

Statement

Reference

Pc² is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Suppressor of

Statement

Reference

Pc² is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Other

Statement

Reference

Antp^Ns, Pc² has antenna phenotype

(Kennison and Tamkun, 1988)

Antp[+]/Antp^Ns, Pc², Scm^K1 has sex comb phenotype

(Kennison and Tamkun, 1988)

Antp[+]/Antp^Ns, Pc², Pcl¹⁸ has sex comb phenotype

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of heterozygous Pc² has no effect on the Pairing sensitive silencing effect seen in w^Mcp.10, and w^Mcp.scs'.11. The addition of heterozygous Pc² has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.11 (P{Mcp-w#11}16/+, P{Mcp-w#11}102/+) double heterozygous insertions. The addition of heterozygous Pc² has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.14/w^Mcp.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) double heterozygous insertions.

(Muller et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

Pc² is not rescued by Pc^EGFP

(Dietzel et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Kyoto

101643

hry¹ Pc² sr¹ e^s / TM1, Me¹ kni^ri-1 Sb^sbd-l

101663

In(3LR)DcxF, ru¹ hry¹ D¹ / Diap1^th-1 st¹ cp¹ Pc²

101644

Diap1^th-1 st¹ cp¹ in¹ kni^ri-1 Pc² sr^61j / TM2, kni^ri-1 Ubx¹³⁰ e^s ca¹

Notes on Origin

Discoverer

Puro, Oct. 1961.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pc²

(Kang et al., 2015, Singh and Mishra, 2015, Bengani et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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