FlyBase Allele Report: Dmel\Scm[R5-13]

General Information

Symbol

Dmel\Scm^R5-13

Species

D. melanogaster

Name

FlyBase ID

FBal0094002

Feature type

allele

Associated gene

Dmel\Scm

Associated Insertion(s)

Carried in Construct

Also Known As

Scm^R5-13B

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bornemann et al., 1998)

Mutagen

X ray

(Bornemann et al., 1998)

Progenitor genotype

Cytology

Description

Deletion of amino acids 270 to 273.

(Bornemann et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:9,636,279..9,636,290 [-]

Comment:

12 bp in-frame deletion.

(Bornemann et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | recessive

(Bornemann et al., 1998)

some die during pupal stage | recessive

(Bornemann et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scm^R5-13 is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Bornemann et al., 1998)

Scm^R5-13 is an enhancer of partially lethal | dominant phenotype of Pc³

(Bornemann et al., 1998)

Other

Statement

Reference

Pc², Scm^R5-13 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Sce^D1, Scm^R5-13 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Scm^R5-13, ph-p⁴⁰⁹ has partially lethal phenotype

(Bornemann et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scm^R5-13 has phenotype, non-enhanceable by lolal^k02512/lolal[+]

(Mishra et al., 2003)

NOT suppressed by

Statement

Reference

Scm^R5-13 has phenotype, non-suppressible by lolal^k02512/lolal[+]

(Mishra et al., 2003)

Enhancer of

Statement

Reference

Scm^R5-13 is an enhancer of phenotype of Pc¹⁵

(Bornemann et al., 1998)

NOT Enhancer of

Statement

Reference

Scm^R5-13/Scm[+] is a non-enhancer of phenotype of lolal^k02512

(Mishra et al., 2003)

Suppressor of

Statement

Reference

Scm^R5-13 is a suppressor of phenotype of z¹

(Bornemann et al., 1998)

NOT Suppressor of

Statement

Reference

Scm^R5-13/Scm[+] is a non-suppressor of phenotype of lolal^k02512

(Mishra et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of heterozygous Scm^R5-13 to lolal^k02512/+ animals shows enhancement or suppression.

(Mishra et al., 2003)

The addition of Scm^R5-13 suppresses the Pairing sensitive silencing effect seen inw^Mcp.y.scs'.1 and strongly suppresses the eye colour phenotype of double insertion combination w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+). The addition of Scm^R5-13 has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.21 or the eye colour of the double insertion combination w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+).

(Muller et al., 1999)

Dominantly enhances the homeotic phenotypes of Pc³/+ adults. Partially lethal in double heterozygous combination with Pc³, Pc² or Sce^D1. ph-p⁴⁰⁹ males that are also heterozygous for Scm^R5-13 show partial lethality.

(Bornemann et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Scm⁴

(Bornemann et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scm^R5-13

Scm^R5-13B

(Singh and Mishra, 2015, Bengani et al., 2013, Vasanthi et al., 2013, Muller et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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