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General Information
Symbol
Dmel\ScmSuz302
Species
D. melanogaster
Name
FlyBase ID
FBal0039014
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(z)302, ScmSu(z)302
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G9636455A

Reported nucleotide change:
Amino acid change:

D215N | Scm-PA; D215N | Scm-PB

Reported amino acid change:
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G to A. Amino acid replacement: D215N. D215N lies within the first of the two mbt repeats.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ScmSuz302/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{wA}4-4. ScmSuz302/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-31.

Pairing sensitive repression is alleviated in iab-7 PRE lines that carry ScmSuz302.

In z1 wzm strain mutation causes reduction of eye pigmentation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

ScmSuz302 is an enhancer of visible | dominant | homeotic phenotype of Pc3

Suppressor of
Statement
Reference

ScmSuz302/Scm[+] is a suppressor of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

ScmSuz302 is a suppressor of visible phenotype of ctpN2s

ScmSuz302 is a suppressor of visible phenotype of ctn2s

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

ScmSuz302 is an enhancer of phenotype of Pc15

Suppressor of
Statement
Reference

ScmSuz302/Scm[+] is a suppressor of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

ScmSuz302 is a suppressor of phenotype of z1

ScmSuz302 is a suppressor of wing phenotype of ctpN2s

ScmSuz302 is a suppressor of wing phenotype of ctn2s

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Sfmbt1 ScmD1/ScmSuz302 double mutant clones in the wing disc have a tumour-like phenotype that is characterized by unrestricted cell proliferation (this phenotype is not seen in single mutant clones).

ScmSuz302 suppresses the pairing-dependent silencing of wenh.iab-7PRE.410 seen in flies homozygous for P{iab-7PRE-wenh.410}1 or P{iab-7PRE-wenh.410}2. ScmSuz302 suppresses the pairing-dependent silencing of wenh.iab-7PRE.260 seen in flies homozygous for P{iab-7PRE-wenh.260}1 or P{iab-7PRE-wenh.260}2.

Dominantly enhances the homeotic phenotypes of Pc3/+ adults. Partially lethal in double heterozygous combination with Pc3, Pc2 or SceD1. ph-p409 males that are also heterozygous for ScmSuz302 show partial lethality.

Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (11)