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General Information
Symbol
Dmel\kisk13416
Species
D. melanogaster
Name
FlyBase ID
FBal0043481
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
kis13416
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}kisk13416
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

kisLM27/kisk13416 third instar larvae do not show gross defects in muscle morphology. Muscle 6 area is normal and the number of boutons per muscle 6/7 neuromuscular junction (NMJ) is not significantly different from wild type. The total number of synaptic branches per muscle 6/7 NMJ is significantly increased compared to wild type.

Muscle 6 area, number of boutons per muscle 6/7 NMJ and total number of synaptic branches per muscle 6/7 NMJ are normal in homozygous kisk13416 larvae.

Homozygous kisk13416 and kisLM27/kisk13416 third instar larvae show a significant decrease in both evoked excitatory junctional current (eEJC) amplitude and in miniature EJC amplitude at the neuromuscular junction compared to controls. mEJC frequency is not significantly different from controls. Quantal content is significantly reduced.

kisk13416 mutant germline clones show oogenesis arrest and oocyte mislocalisation.

Polytene chromosomes of homozygotes sometimes appear slightly thinner than normal, but their overall morphology and banding pattern is not significantly altered from wild type.

Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

kisk13416/kis[+] is an enhancer of visible phenotype of DgdsRNA.UAS, Scer\GAL4Tub.PU

kisk13416 is an enhancer of visible | dominant phenotype of tna1

NOT Enhancer of
Statement
Reference

kisk13416 is a non-enhancer of visible phenotype of RetGMR.PR

Suppressor of
Statement
Reference

kisk13416 is a suppressor of visible phenotype of RetMEN2B.GMR

kisk13416/kis[+] is a suppressor of visible phenotype of pnrMD237

NOT Suppressor of
Statement
Reference

kisk13416/kis[+] is a non-suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

kisk13416 is a non-suppressor of visible phenotype of RetGMR.PR

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

kisk13416/kis[+] is an enhancer of eye | heat sensitive phenotype of Df(3R)p13/ato1090

kisk13416/kis[+] is an enhancer of photoreceptor cell | heat sensitive phenotype of Df(3R)p13/ato1090

kisk13416/kis[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1

kisk13416 is an enhancer of wing phenotype of tna1

NOT Enhancer of
Statement
Reference

kisk13416 is a non-enhancer of eye phenotype of RetGMR.PR

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

kisk13416 is a non-suppressor of eye phenotype of RetGMR.PR

Other
Additional Comments
Genetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is not affected by combination with a single copy of kisk13416.

One copy of kisk13416 strongly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU but produces extra wing vein material.

One copy of kisk13416 strongly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU but produces extra wing vein material.

One copy of kisk13416 in a DysE6/+ background results in posterior crossvein defects.

One copy of kisk13416 enhances the posterior crossvein phenotype seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

A kisk13416 heterozygous background gives a dominant mild enhancement to the ato1090/Df(3R)p13 eye phenotype at 25[o]C.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is not affected by combination with a single copy of kisk13416.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

I. Kiss.

Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (17)