FB2026_02 , released June 18, 2026
Allele: Dmel\kisEC1
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General Information
Symbol
Dmel\kisEC1
Species
D. melanogaster
Name
FlyBase ID
FBal0267209
Feature type
allele
Associated gene
Dmel\kis
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Melicharek et al., 2008)
Progenitor genotype
Cytology
Description

Point mutation (C2617T) in the transcript that encodes the long kis isoform; this is predicted to result in a premature stop codon (FlyBase curator comment: the mutation is reported as occurring at residue Q872, but there is no Q residue at position 872 in the reference sequence, instead the change that introduces the premature stop codon has been mapped to residue Q873).

(Gervais et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:239,571..239,571 [-]
Nucleotide change:

C239571T

Reported nucleotide change:

C2617T

Amino acid change:

Q873term | kis-PA; Q873term | kis-PC; Q873term | kis-PD; Q873term | kis-PE; Q873term | kis-PF

Reported amino acid change:

Q872term

Comment:

The mutation is reported to be at aa residue Q872 (codon CAG) but there is no Gln at position 872 in the reference sequence. It was mapped to Q873.

(Gervais et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      kisEC1/kisEC1 somatic clones in a heterozygous background contain a greater overall number of cells and significantly more intestinal stem cells in adult flies compared to controls.

      (Gervais et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      kis[+]/kisEC1 is an enhancer of eye | heat sensitive phenotype of Df(3R)p13/ato1090

      (Melicharek et al., 2008)

      kis[+]/kisEC1 is an enhancer of photoreceptor neuron | heat sensitive phenotype of Df(3R)p13/ato1090

      (Melicharek et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A kisEC1 heterozygous background gives a dominant mild enhancement to the ato1090/Df(3R)p13 eye phenotype at 25[o]C.

      (Melicharek et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      kis1

      (Melicharek et al., 2008)

      kisk13416

      (Melicharek et al., 2008)
      Rescued by

      kisEC1 is rescued by kisUAS.L.Tag:polyHis,Tag:FLAG/Scer\GAL4Tub.PU

      (Gervais et al., 2019)
      Comments

      Expressing kisUAS.L.Tag:polyHis,Tag:FLAG under the control of Scer\GAL4Tub.PU fully rescues the increased overall number of cells and of intestinal stem cells in somatic clones homozygous for kisEC1.

      (Gervais et al., 2019)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kisEC1
      (Gervais et al., 2019, Melicharek et al., 2008)
      Name Synonyms
      kismetEC1
      (Melicharek et al., 2008)
      Secondary FlyBase IDs
        References (2)