FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lwr13
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General Information
Symbol
Dmel\lwr13
Species
D. melanogaster
Name
FlyBase ID
FBal0189967
Feature type
allele
Associated gene
Dmel\lwr
Associated Insertion(s)
P{PZ}lwr13
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sun et al., 2003)
Mutagen
Delta2-3 transposase
(Sun et al., 2003)
Progenitor genotype
lwrsemi710
(Sun et al., 2003)
Associated Insertion(s)
P{PZ}lwr13
Cytology
Description

Imprecise excision: results in a 1603bp deletion from 18bp upstream of the 5' end of the lwr gene to 299bp downstream of the poly(A) site of Spp. P{PZ} sequences are retained at the site of the original insertion.

(Sun et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dendrites of MARCM lwr13 mutant DL1 projection neuron single cell clones innervate large areas across the entire antennal lobe. In 58% of cases, lwr13 dl1 projection neuron dendrites shift ventromedially from DL1 and avoid the DL1 glomerulus. In 21% of cases they innervate the DL1 glomerulus but spill into several adjacent glomeruli, with the remaining 21% innervating simultaneously dorsolateral and ventromedial portions of the antennal lobe.

      (Berdnik et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      lwr13/lwr[+] is an enhancer of visible | dominant phenotype of tna1

      (Monribot-Villanueva et al., 2013)
      Suppressor of
      Statement
      Reference

      lwr13/lwr[+] is a suppressor of abnormal neuroanatomy | somatic clone phenotype of veloLL05209

      (Berdnik et al., 2012)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      lwr13/lwr[+] is an enhancer of wing phenotype of tna1

      (Monribot-Villanueva et al., 2013)
      Suppressor of
      Statement
      Reference

      lwr13/lwr[+] is a suppressor of adult antennal lobe projection neuron DL1 adPN | somatic clone phenotype of veloLL05209

      (Berdnik et al., 2012)

      lwr13/lwr[+] is a suppressor of antennal lobe glomerulus DL1 | somatic clone phenotype of veloLL05209

      (Berdnik et al., 2012)

      lwr13/lwr[+] is a suppressor of dendrite | somatic clone phenotype of veloLL05209

      (Berdnik et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      lwr13/+ enhances both the penetrance and expressivity of the held-out wing phenotype of tna1/+ flies.

      (Monribot-Villanueva et al., 2013)

      A lwr13 heterozygous background suppress the dendritic mistargeting seen in veloLL05209 mutant DL1 projection neurons.

      (Berdnik et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      lwr14

      (Sun et al., 2003)

      lwr5

      (Sun et al., 2003)
      Rescued by

      lwr13 is rescued by lwrUAS.cAa/Scer\GAL4GH146

      (Berdnik et al., 2012)
      Comments

      Expression of lwrScer\UAS.cAa under the control of Scer\GAL4GH146 fully rescues the dendrite mistargeting defects in lwr13 mutants.

      (Berdnik et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Df(2L)lwr13
      (Sun et al., 2003)
      lwr13
      (Gao et al., 2024, Monribot-Villanueva et al., 2013, Berdnik et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)