FlyBase Allele Report: Dmel\Bap60[1]

General Information

Symbol

Dmel\Bap60¹

Species

D. melanogaster

Name

FlyBase ID

FBal0248828

Feature type

allele

Associated gene

Dmel\Bap60

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Möller et al., 2005)

Progenitor genotype

P{Mae-UAS.6.11}CG12096^GG01131

(Möller et al., 2005)

Caused by aberration

Df(1)Bap60¹

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 2kb deletion that removes the N-terminal portion of the Bap60 coding region and an N-terminal portion of the CG12096 gene.

(Möller et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive

(Möller et al., 2005)

lethal | embryonic stage | recessive

(Möller et al., 2005)

lethal | larval stage | recessive

(Möller et al., 2005)

suppressor of variegation | dominant

(Möller et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Approximately two-thirds of hemizygous male embryos die prior to hatching, while the remaining male hemizygotes die during early larval stages.

Eggs derived from females carrying homozygous germline clones are partially deformed or deflated and no larvae hatch from these eggs.

Bap60¹/+ completely suppresses the position effect variegation at the w locus which is caused by In(1)w^m4h.

(Möller et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Bap60[+]/Bap60¹ is an enhancer of visible | dominant phenotype of brm²

(Möller et al., 2005)

Bap60[+]/Bap60¹ is an enhancer of visible | dominant phenotype of brm², trx[+]/trx^E2

(Möller et al., 2005)

Bap60[+]/Bap60¹ is an enhancer of visible | dominant phenotype of mor¹

(Möller et al., 2005)

Suppressor of

Statement

Reference

Bap60[+]/Bap60¹ is a suppressor of visible | dominant phenotype of Antp^Ns

(Möller et al., 2005)

NOT Suppressor of

Statement

Reference

Bap60[+]/Bap60¹ is a non-suppressor of visible | dominant phenotype of Antp^73b

(Möller et al., 2005)

Other

Statement

Reference

Bap60¹, sisA[+]/sisA¹, upd1^sisC-1/os[+] has partially lethal - majority die | dominant | maternal effect | female limited phenotype

(Möller et al., 2005)

Bap60¹, sisA[+]/sisA¹ has partially lethal - majority die | dominant | maternal effect | female limited phenotype

(Möller et al., 2005)

Bap60¹, Df(1)sc19/+ has partially lethal - majority die | dominant | maternal effect | female limited phenotype

(Möller et al., 2005)

Bap60¹, Df(1)sc10-1/+ has partially lethal - majority die | dominant | maternal effect | female limited phenotype

(Möller et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

Bap60[+]/Bap60¹ is an enhancer of humeral bristle phenotype of brm²

(Möller et al., 2005)

Bap60[+]/Bap60¹ is an enhancer of humeral bristle phenotype of brm², trx[+]/trx^E2

(Möller et al., 2005)

Bap60[+]/Bap60¹ is an enhancer of humeral bristle phenotype of mor¹

(Möller et al., 2005)

Suppressor of

Statement

Reference

Bap60[+]/Bap60¹ is a suppressor of antenna phenotype of Antp^Ns

(Möller et al., 2005)

Bap60[+]/Bap60¹ is a suppressor of leg | ectopic phenotype of Antp^Ns

(Möller et al., 2005)

NOT Suppressor of

Statement

Reference

Bap60[+]/Bap60¹ is a non-suppressor of antenna phenotype of Antp^73b

(Möller et al., 2005)

Bap60[+]/Bap60¹ is a non-suppressor of leg | ectopic phenotype of Antp^73b

(Möller et al., 2005)

Other

Statement

Reference

Bap60[+]/Bap60¹, akirin^EP906 has larval somatic muscle cell phenotype

(Nowak et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Stage 16 Bap60¹/+ ; akirin^EP906/+ double heterozygous embryos show disruption of the somatic muscle pattern (20.2% of embryos have missing, misattached or duplicated muscles in at least 2 hemisegments).

(Nowak et al., 2012)

The penetrance of the loss of humeral bristle phenotype seen in brm²/+ flies is increased by Bap60¹/+ from 7% to 14%.

5% of brm² trx^E2 double heterozygotes show loss of humeral bristles. The penetrance of this phenotype is increased to 15% by Bap60¹/+.

Bap60¹/+ ; trx^E2/+ double heterozygotes do not show loss of humeral bristles.

The penetrance of the loss of humeral bristle phenotype seen in mor¹/+ flies is increased by Bap60¹/+ from 3% to 7%.

The penetrance of the antenna to leg transformation phenotype seen in Antp^Ns/+ flies is slightly suppressed by Bap60¹/+ from 100% to 92%.

The antenna to leg transformation phenotype seen in Antp^73b/+ flies is not suppressed by Bap60¹/+.

Maternal heterozygosity for Bap60¹ reduces the viability of female offspring which are doubly heterozygous for sisA¹ upd1^sisC-1.

Maternal heterozygosity for Bap60¹ reduces the viability of female offspring which are heterozygous for sisA¹.

Maternal heterozygosity for Bap60¹ reduces the viability of female offspring which are heterozygous for Df(1)sc19.

Maternal heterozygosity for Bap60¹ reduces the viability of female offspring which are heterozygous for Df(1)sc10-1.

(Möller et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bap60¹ is rescued by Bap60^Act5C.PM

(Möller et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Bap60¹

(Nowak et al., 2012, Möller et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close