FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cup15
Open Close
General Information
Symbol
Dmel\cup15
Species
D. melanogaster
Name
FlyBase ID
FBal0002160
Feature type
allele
Associated gene
Dmel\cup
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Keyes and Spradling, 1997, Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Egg chambers arrest at stage S7-8. Nurse cell nuclear chromatin in the oldest egg chambers appears decondensed. cup15 has a dominant effect on meiotic X chromosome segregation.

      (Keyes and Spradling, 1997)

      Abnormalities in follicle cell migration: open ended chorion.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      cup15 has egg chamber phenotype, enhanceable by mira[+]/miraAB78

      (Piccioni et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by miraJJ92/mira[+]

      (Piccioni et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by miraL44/mira[+]

      (Piccioni et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by miraYY227/mira[+]

      (Piccioni et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by Hsp8319F2/Hsp83[+]

      (Pisa et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by Hsp83[+]/Hsp83e6A

      (Pisa et al., 2009)

      cup15 has egg chamber phenotype, enhanceable by otu11

      (Keyes and Spradling, 1997)
      Enhancer of
      Statement
      Reference

      cup15/cup15 is an enhancer of egg chamber phenotype of otu11

      (Keyes and Spradling, 1997)
      Suppressor of
      Statement
      Reference

      cup15 is a suppressor of phenotype of nanos18

      (Verrotti and Wharton, 2000)
      Other
      Statement
      Reference

      cup15, otu[+]/otu11 has nurse cell & chromatin phenotype

      (Keyes and Spradling, 1997)

      cup15, otu11 has ovariole phenotype

      (Keyes and Spradling, 1997)

      cup15, otu11 has nurse cell & chromatin phenotype

      (Keyes and Spradling, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ovarian phenotype of cup15 homozygous females is enhanced if they are also heterozygous for one of miraAB78, miraJJ92, miraL44 or miraYY227; a greater fraction of egg chambers arrest development between stages 3 and 5 in the double mutant ovaries compared to in the single mutant ovaries.

      (Piccioni et al., 2009)

      The oogenesis defects seen in cup15 females are enhanced if they are also heterozygous for Hsp8319F2 or Hsp83e6A.

      (Pisa et al., 2009)

      cup15 otu11 double homozygotes (raised at the restrictive temperature for otu11) have a more severe phenotype than either single mutant homozygote: ovarioles are either extremely tumorous, with no budded chambers, or appear completely agametic. cup15/cup15 otu11/+ females (raised at the restrictive temperature for otu11) are fertile, although some eggs laid have flaccid chorions and do not hatch. Nurse cell chromatin morphology is not completely normal in these females, and 18% of egg chambers are dicephalic.

      (Keyes and Spradling, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cup15
      (Saha et al., 2023, Piccioni et al., 2009, Pisa et al., 2009)
      cupQJ36
      Name Synonyms
      Secondary FlyBase IDs
        References (7)