FlyBase Allele Report: Dmel\PTP-ER[XE-2776]

General Information

Symbol

Dmel\PTP-ER^XE-2776

Species

D. melanogaster

Name

FlyBase ID

FBal0098355

Feature type

allele

Associated gene

Dmel\PTP-ER

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

In(2R)XE-2776

Cytology

Description

Inversion breakpoint in the catalytic domain of PTP-ER.

(Karim and Rubin, 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Karim and Rubin, 1999)

visible | recessive

(Karim and Rubin, 1999)

Phenotype Manifest In

eye

(Karim and Rubin, 1999)

eye photoreceptor cell

(Karim and Rubin, 1999)

ommatidium

(Karim and Rubin, 1999)

photoreceptor cell R7 | ectopic

(Karim and Rubin, 1999)

Detailed Description

Statement

Reference

Displays a very mild eye roughness due to the recruitment of ectopic R7 cells when hemizygous with a deficiency for the 57F--58A region.

(Karim and Rubin, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

PTP-ER^XE-2776 is an enhancer of visible phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

Suppressor of

Statement

Reference

PTP-ER^XE-2776 is a suppressor of lethal phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Maher et al., 2011)

PTP-ER^XE-2776 is a suppressor of visible | recessive phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of visible | recessive phenotype of Raf¹²

(Karim and Rubin, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

PTP-ER^XE-3022/PTP-ER^XE-2776 has photoreceptor cell R7 | increased number phenotype, enhanceable by alph^S-331

(Baril and Therrien, 2006)

Enhancer of

Statement

Reference

PTP-ER^XE-3022/PTP-ER^XE-2776 is an enhancer of photoreceptor cell R7 | increased number phenotype of alph^S-331

(Baril and Therrien, 2006)

PTP-ER^XE-2776 is an enhancer of ommatidium phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is an enhancer of eye phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

Suppressor of

Statement

Reference

PTP-ER^XE-2776 is a suppressor of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Maher et al., 2011)

PTP-ER^XE-2776 is a suppressor of eye photoreceptor cell phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of photoreceptor cell R7 phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of photoreceptor neuron phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of eye phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of eye phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of photoreceptor neuron phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-2776 is a suppressor of eye phenotype of Raf¹²

(Karim and Rubin, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

PTP-ER^XE-3022/PTP-ER^XE-2776 do not show synthetic lethality when placed in an alph^S-331 homozygous background, however, a significant increase of extra R7 cells is observed compared to the respective single homozygotes.

(Baril and Therrien, 2006)

Enhancer of the Ras85D^V12.sev rough eye phenotype. Heterozygous PTP-ER^XE-2776 suppresses the rough eyes and loss of photoreceptor cells seen in either hemizygous Dsor1^XS520, hemizygous phl¹² or homozygous ksr^S-548.

(Karim and Rubin, 1999)

Xenogenetic Interactions

Statement

Reference

The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is partially suppressed in a PTP-ER^XE-2776/+ background.

(Maher et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5765

In(2R)XE-2776, PTP-ER^XE-2776/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PTP-ER^XE-2776

(Maher et al., 2011, Baril and Therrien, 2006)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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