FlyBase Allele Report: Dmel\ksr[S-548]

General Information

Symbol

Dmel\ksr^S-548

Species

D. melanogaster

Name

FlyBase ID

FBal0049699

Feature type

allele

Associated gene

Dmel\ksr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Therrien et al., 1995)

Mutagen

Progenitor genotype

Cytology

Description

4bp substitution that changes two consecutive amino acids in the N-terminus of the protein. Amino acid replacement: L50S. Amino acid replacement: R51G.

(Therrien et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

3R:5,483,487..5,483,490 [-]

Amino acid change:

L50S|ksr-PA

Amino acid change:

R51G|ksr-PA

Reported amino acid change:

L50S

Reported amino acid change:

R51G

Comment:

A 4bp substitution that changes two consecutive amino acids. The amino acid changes are L50S and R51G.

Inserted_sequence:

AGTG

(Therrien et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Lai et al., 1997)

visible | recessive

(Karim and Rubin, 1999)

Phenotype Manifest In

eye

(Karim and Rubin, 1999, Therrien et al., 1995)

eye photoreceptor cell

(Lai et al., 1997)

ommatidium

(Karim and Rubin, 1999)

photoreceptor neuron

(Karim and Rubin, 1999, Therrien et al., 1995)

Detailed Description

Statement

Reference

Few ommatidia contain the normal complement of receptor cells.

(Lai et al., 1997)

Homozygotes are subviable and have rough eyes.

(Therrien et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ksr^S-548 has visible | recessive phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

ksr^S-548 has visible | recessive phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

ksr^S-548 has visible phenotype, suppressible by ttk^190.1

(Lai et al., 1997)

ksr^S-548 has visible phenotype, suppressible by aop^yan-XE18

(Lai et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

ksr^S-548 has eye phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

ksr^S-548 has ommatidium phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

ksr^S-548 has photoreceptor neuron phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

ksr^S-548 has eye phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

ksr^S-548 has ommatidium phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

ksr^S-548 has photoreceptor neuron phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

ksr^S-548 has eye photoreceptor cell phenotype, suppressible by aop^yan-XE18

(Lai et al., 1997)

ksr^S-548 has eye photoreceptor cell phenotype, suppressible by ttk^190.1

(Lai et al., 1997)

Suppressor of

Statement

Reference

ksr^S-548 is a suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous PTP-ER^XE-3022, PTP-ER^XE-2776 as well as deficiency alleles of PTP-ER suppress the rough eyes and loss of photoreceptor cells seen in homozygous ksr^S-548.

(Karim and Rubin, 1999)

Up to 99% ommatidia are wild type in a aop^yan-XE18 or ttk^190.1 mutant background.

(Lai et al., 1997)

Dominantly suppresses the rough eye phenotype of Ras85D^V12.sev.

(Therrien et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ksr^S-548

ksr^XS-548

(Karim and Rubin, 1999)

ksr^XS548

(Lai et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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