FlyBase Allele Report: Dmel\Egfr[unspecified]

General Information

Symbol

Dmel\Egfr^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0066102

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

EGFR^null

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | somatic clone

(Yang and Baker, 2003)

lethal | recessive

(Therrien et al., 2000)

lethal - all die during embryonic stage | non-rescuable maternal effect

(Hsu et al., 2001)

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | non-rescuable maternal effect

(Hsu et al., 2001)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

Detailed Description

Statement

Reference

Egfr^unspecified mutant cells are nearly always located at the rear of the cluster during border cell dorsal migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

(Bianco et al., 2007)

In Egfr^unspecified mutant somatic clones in the 3rd instar eye disc, photoreceptors R2-R5 fail to undergo or differentiation. Within Egfr^unspecified mutant somatic clones there is a failure of G1 arrest in the furrow: all cells except R8s re-enter the cell cycle. However, none of these cells progress past G2.

(Yang and Baker, 2003)

Mutant females produce eggs with either narrowed and fused dorsal appendages or no appendages at all. Embryos produced from mutant females mated to wild-type males show cuticle patterning defects; expanded and fused ventral denticles.

(Hsu et al., 2001)

Collapsed CNS axon phenotype with frequent breaks in the longitudinal connectives. Midline glial cells are displaced ventrally at stage 12. By stage 16 midline glial cells are no longer evident, having degenerated.

(Hummel et al., 1999)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Embryos form a ball of dorsal hypoderm with the external organs extruded anteriorly. Ventral cuticle is absent or strongly reduced. Abnormalities are first visible in the extended germ band stage. Pole cell transplantation experiments suggest there is no maternal effect.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Egfr[+]/Egfr^unspecified is an enhancer of lethal phenotype of Raf¹²

(Therrien et al., 2000)

Egfr[+]/Egfr^unspecified is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

NOT Enhancer of

Statement

Reference

Egfr[+]/Egfr^unspecified is a non-enhancer of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

NOT Suppressor of

Statement

Reference

Egfr[+]/Egfr^unspecified is a non-suppressor of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Egfr^unspecified is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, nej^ΔBHQ.UAS

(Anderson et al., 2005)

Egfr[+]/Egfr^unspecified is an enhancer of axon & mechanosensory neuron & adult head phenotype of Scer\GAL4^sca-537.4, htl^DN.UAS.cMb

(Garcia-Alonso et al., 2000)

Egfr^unspecified is an enhancer of axon & ocellus sensory structure | conditional ts phenotype of Nrg^l10

(Garcia-Alonso et al., 2000)

Egfr^unspecified is an enhancer of axon & mechanosensory neuron & adult head | conditional ts phenotype of Nrg^l10

(Garcia-Alonso et al., 2000)

Egfr[+]/Egfr^unspecified is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

Egfr^unspecified is an enhancer of wing vein | ectopic phenotype of rl^Sem

(Brunner et al., 1994)

NOT Enhancer of

Statement

Reference

Egfr[+]/Egfr^unspecified is a non-enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

Egfr[+], Egfr^unspecified, Scer\GAL4^Bx-MS1096 is a suppressor of wing vein | ectopic phenotype of Pstu\aarA^UAS.cGa

(Gallio et al., 2002)

Egfr[+], Egfr^unspecified, Scer\GAL4^Bx-MS1096 is a suppressor of wing phenotype of Pstu\aarA^UAS.cGa

(Gallio et al., 2002)

Egfr^unspecified is a suppressor of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^UAS.cHa

(Hsiao et al., 2001)

Egfr^unspecified is a suppressor of wing phenotype of Scer\GAL4^dpp.PH, eya^UAS.cHa

(Hsiao et al., 2001)

Egfr[+]/Egfr^unspecified is a suppressor of axon & ocellus sensory structure phenotype of Scer\GAL4^sca-537.4, htl^DN.UAS.cMb

(Garcia-Alonso et al., 2000)

Egfr[+]/Egfr^unspecified is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

NOT Suppressor of

Statement

Reference

Egfr[+]/Egfr^unspecified is a non-suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Egfr^unspecified Pvr^unspecified double mutant cells are generally located at the rear of the cluster during border cell posterior migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

(Bianco et al., 2007)

Within Egfr^unspecified mutant clones in the eye disc in a BacA\p35^GMR.PH background, caspase activation is seen posterior to column 5, relative to the morphogenetic furrow. There is no increase in caspase activation outside of these clones.

(Yang and Baker, 2003)

The proportion of eya^Scer\UAS.cHa; Scer\GAL4^dpp.PH flies with blistered wings (76%) is decreased by heterozygosity for Egfr^unspecified to 14%, while the proprotion with only mild wing defects is increased from 24% to 86%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

(Hsiao et al., 2001)

The addition of Egfr^unspecified to Egfr^{DN.Scer\UAS.cBa} animals (when driven by Scer\GAL4^unspecified) causes a suppression of the Ocellar pioneer (OP) axon phenotypes and an enhancement of the bristle mechanosensory (BM) phenotypes.

(Garcia-Alonso et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Egfr^k05115

(Dworkin and Gibson, 2006)

Egfr^SOK5

(Alvarado et al., 2004)

Egfr¹⁵

(Zhang et al., 1999)

Egfr^24-1

(Zhang et al., 1999)

Egfr^26-3

(Zhang et al., 1999)

Egfr²⁷

(Zhang et al., 1999)

Egfr^30-1

(Zhang et al., 1999)

Egfr^40-6

(Zhang et al., 1999)

Egfr⁴

(Zhang et al., 1999)

Egfr⁵

(Zhang et al., 1999)

Egfr⁶

(Zhang et al., 1999)

Egfr^9-2

(Zhang et al., 1999)

Egfr⁹

(Zhang et al., 1999)

Partially rescued by

Egfr^unspecified is partially rescued by Egfr^mSa

(Schejter and Shilo, 1989)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The ectopic veination and mild blistering seen in the wings of Pstu\aarA^Scer\UAS.cGa; Scer\GAL4^Bx-MS1096 flies is partially suprressed by heterozygosity for spi^unspecified or Egfr^unspecified.

(Gallio et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EGFR^null

(Requena et al., 2017, Nagaraj and Banerjee, 2007)

Egfr^-

(Bianco et al., 2007)

Egfr^flb

(Hsiao et al., 2001)

Egfr^unspecified

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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