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General Information
Symbol
Dmel\alphS-355
Species
D. melanogaster
Name
FlyBase ID
FBal0120640
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    G29593867A

    Amino acid change:

    G173S | alph-PA; G173S | alph-PB; G173S | alph-PC; G173S | alph-PD; G173S | alph-PE; G173S | alph-PF

    Reported amino acid change:

    G173S

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: G173S.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    alphS-355/pp2c99B[+] is an enhancer of visible phenotype of Ras85DV12.sev

    Suppressor of
    Statement
    Reference

    alphS-355/alph[+] is a suppressor of lethal phenotype of slprBS06

    alphS-355/alph[+] is a suppressor | partially of lethal phenotype of licG0252

    alphS-355/pp2c99B[+] is a suppressor of lethal phenotype of Raf12

    alphS-355/pp2c99B[+] is a suppressor of visible phenotype of ksr::torΔNksr.hs.sev

    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    alphS-355 is an enhancer of eye phenotype of Ras85DV12.sev

    alphS-355/pp2c99B[+] is an enhancer of eye phenotype of Ras85DV12.sev

    NOT Enhancer of
    Statement
    Reference

    alphS-355 is a non-enhancer of eye phenotype of phylhs.sev

    Suppressor of
    Statement
    Reference

    alphS-355/pp2c99B[+] is a suppressor of eye phenotype of ksr::torΔNksr.hs.sev

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Introduction of a heterozygous alphS-355 allele into the licG0252 background suppresses hemizygous male lethality.

    Introduction of a heterozygous alphS-355 allele into the hepG0107 background suppresses hemizygous male lethality.

    alphS-355 restores viability to slprBS06/Y males.

    rlSem.sev heterozygous mutants in combination with alphS-355 exhibit a rough eye phenotype. They exhibit an average of 3.39 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type.

    ksr::torΔNksr.hs.sev/alphS-355 mutants exhibit a 20% loss of ommatidial R7 cells, indicating that alphS-355 has suppressed the ksr::torΔNksr.hs.sev phenotype. This effect is not specific to the R7 cells as the loss of outer photoreceptors is suppressed in this double mutant.

    The rough eye phenotype of Ras85DV12.sev mutants is increased when transheterozygous with alphS-355.

    phylhs.sev heterozygous mutants in combination with alphS-355 exhibit a rough eye phenotype. They exhibit an average of 1.70 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phylhs.sev heterozygous mutants.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    pp2c99BS-355
    Name Synonyms
    Secondary FlyBase IDs
      References (3)