FlyBase Allele Report: Dmel\phyl[hs.sev]

General Information

Symbol

Dmel\phyl^hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0044267

Feature type

allele

Associated gene

Dmel\phyl

Associated Insertion(s)

Carried in Construct

P{sE-phyl.D}

Also Known As

sE-phyl

Key Links

Transgenic product class

cDNA

(Dickson et al., 1995)

wild_type

(Dickson et al., 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Dickson et al., 1995)

wild_type

(Dickson et al., 1995)

Mutagen

in vitro construct

(Dickson et al., 1995)

Progenitor genotype

Carried in construct

P{sE-phyl.D}

Cytology

Description

phyl cDNA is expressed under the transcriptional control of an Hsp70 promoter and one copy of the sev enhancer.

(Dickson et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

phyl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Tang et al., 1997)

Phenotype Manifest In

cone cell | precursor

(Dickson et al., 1995)

eye

(Baril and Therrien, 2006, Tang et al., 1997, Dickson et al., 1995)

photoreceptor cell R1

(Nagaraj and Banerjee, 2009)

photoreceptor cell R6

(Nagaraj and Banerjee, 2009)

photoreceptor cell R7

(Dickson et al., 1995)

photoreceptor cell R7 | increased number

(Baril and Therrien, 2006)

Detailed Description

Statement

Reference

phyl^hs.sev heterozygous mutants exhibit a rough eye phenotype. They exhibit an average of 1.71 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type.

(Baril and Therrien, 2006)

14-3-3ε^S-696 does not show any dominant interaction with phyl^hs.sev.

(Chang and Rubin, 1997)

Eyes are roughened. Ectopic R7 cells develop. Additional R7 cells is independent of sev activity but depends on sina function. Additional R7 cells are derived from cone cell precursors.

(Dickson et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

phyl^hs.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

phyl^hs.sev, ttk^{88.hs.sev.Tag:MYC} has visible phenotype

(Tang et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

phyl^hs.sev has phenotype, enhanceable by ttk¹

(Tang et al., 1997)

NOT Enhanced by

Statement

Reference

phyl^hs.sev has eye phenotype, non-enhanceable by alph^S-331

(Baril and Therrien, 2006)

phyl^hs.sev has eye phenotype, non-enhanceable by alph^S-355

(Baril and Therrien, 2006)

Suppressed by

Statement

Reference

phyl^hs.sev has photoreceptor cell R1 phenotype, suppressible by N^ΔE.UAS/Scer\GAL4^hs.2sev

(Nagaraj and Banerjee, 2009)

phyl^hs.sev has photoreceptor cell R6 phenotype, suppressible by N^ΔE.UAS/Scer\GAL4^hs.2sev

(Nagaraj and Banerjee, 2009)

phyl^hs.sev has phenotype, suppressible by lilli^XS407

(Tang et al., 2001)

phyl^hs.sev has phenotype, suppressible by lilli^s35

(Tang et al., 2001)

phyl^hs.sev has phenotype, suppressible by lilli^XS575

(Tang et al., 2001)

phyl^hs.sev has phenotype, suppressible by sina²

(Tang et al., 1997)

phyl^hs.sev has phenotype, suppressible by sina³

(Tang et al., 1997)

Other

Statement

Reference

phyl^hs.sev, ttk^{88.hs.sev.Tag:MYC} has eye phenotype

(Tang et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

phyl^hs.sev heterozygous mutants in combination with alph^S-331 exhibit a rough eye phenotype. They exhibit an average of 1.72 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phyl^hs.sev heterozygous mutants.

phyl^hs.sev heterozygous mutants in combination with alph^S-355 exhibit a rough eye phenotype. They exhibit an average of 1.70 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phyl^hs.sev heterozygous mutants.

(Baril and Therrien, 2006)

Not lethal in combination with sev^{S11.T:Hsap\MYC}.

(Maixner et al., 1998)

Flies carrying both phyl^hs.sev and ttk^{88.hs.sev.T:Hsap\MYC} have more normal eyes than flies carrying either phyl^hs.sev or ttk^{88.hs.sev.T:Hsap\MYC} alone. The phyl^hs.sev phenotype is weakly enhanced by ttk¹/+.

(Tang et al., 1997)

Xenogenetic Interactions

Statement

Reference

Combination of phyl^hs.sev and Scer\GAL4^hs.2sev-driven expression of Dl::N^{ΔECN.Scer\UAS} results in a significant rescue in the specification of R1 and R6 cell types.

(Nagaraj and Banerjee, 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

phyl^hs.sev

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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