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Citation
Nagaraj, R., Banerjee, U. (2009). Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway.  EMBO J. 28(4): 337--346.
FlyBase ID
FBrf0206749
Publication Type
Research paper
Abstract

Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated at multiple levels. Here, we present an analysis of Phyllopod as a coordinated regulator of these two critical signal transduction pathways. Phyl specifically helps traffic Notch and Wg pathway components within early endocytic vesicles, thereby controlling the amount of processed signal available for causing a transcriptional response within the nucleus. In Drosophila, the EGFR pathway transcriptionally activates phyl whose product then blocks Notch and Wg signalling pathways. This provides a mechanistic basis for an antagonistic relationship between receptor tyrosine kinase and Notch/Wg pathways during development. Furthermore, this study identifies a Phyl-regulated class of endosomal vesicles that specifically include components of Notch and Wg signalling.

PubMed ID
PubMed Central ID
PMC2646148 (PMC) (EuropePMC)
Related Publication(s)
Note

Phyllopod at the intersection of developmental signalling pathways.
Shilo, 2009, EMBO J. 28(4): 311--312 [FBrf0206792]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference