FlyBase Allele Report: Dmel\hep[G0107]

General Information

Symbol

Dmel\hep^G0107

Species

D. melanogaster

Name

FlyBase ID

FBal0102654

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

P{lacW}hep^G0107

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.12.10)

Progenitor genotype

Associated Insertion(s)

P{lacW}hep^G0107

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:13,089,677..13,090,188 [-]

(Guichard et al., 2006, Peter et al., 2002, Schäfer et al., 1999.12.10)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426887

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Schäfer et al., 1999.12.10)

lethal - all die before end of pupal stage

(Peter et al., 2002)

lethal - all die during P-stage

(Baril et al., 2009)

some die during pupal stage

(Peter et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

hep^G0107/Y males die at the pupal stage.

(Baril et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hep^G0107 has lethal - all die during P-stage phenotype, suppressible by alph^S-331/alph^S-331

(Baril et al., 2009)

hep^G0107 has lethal - all die during P-stage phenotype, suppressible | partially by alph^S-331/alph[+]

(Baril et al., 2009)

hep^G0107 has lethal - all die during P-stage phenotype, suppressible | partially by alph^XS-88/alph[+]

(Baril et al., 2009)

hep^G0107 has lethal - all die during P-stage phenotype, suppressible | partially by alph^S-355/alph[+]

(Baril et al., 2009)

hep^G0107 has lethal - all die during P-stage phenotype, suppressible | partially by alph^c04528/alph[+]

(Baril et al., 2009)

Suppressor of

Statement

Reference

hep[+]/hep^G0107 is a suppressor of radiation sensitive phenotype of alph^S-331

(Baril et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of a homozygous alph^S-331 allele into the hep^G0107 background strongly suppresses hemizygous male lethality.

Introduction of a heterozygous alph^S-331, alph^XS-88, alph^S-355, or alph^c04528 allele into the hep^G0107 background suppresses hemizygous male lethality.

hep^G0107/+ suppresses the eye loss enhancement seen in alph^S-331 homozygotes following UVC irradiation of 24-hr pupal eyes.

(Baril et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10082

w^67c23 P{lacW}hep^G0107/FM7c

Kyoto

111740

y¹ w^* P{lacW}hep^G0107 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.12.10)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426887

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hep^G0107

(Guichard et al., 2006)

hep^G0107

(Marchal et al., 2012, Baril et al., 2009)

l(1)G0107

(Peter et al., 2002)

l(1)G0107^G0107

(Schäfer et al., 1999.12.10)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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