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General Information
Symbol
Dmel\ifB2
Species
D. melanogaster
Name
FlyBase ID
FBal0031512
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult ifB2 homozygous mutant intestinal stem cell clones have similar maintenance 7 days and 14 days after clone induction compared to control clones.

Fewer haemocytes are observed migrating into the tail region in ifB2 mutant embryos. There is no decrease in migration to the dorsal vessel or ventral nerve cord in these animals.

ifB2 mutant embryos develop a mild muscle detachment phenotype in several segments.

When tested in the odour-induced jump-test, double heterozygotes of swsolfE-x26 and ifB2 exhibit a reduced response to benzaldehyde, but not to iso-amyl acetate or ethyl acetate, compared to controls

Stage 14 oocytes carrying ifB2 somatic clones are much more rounded than wild-type.

Embryos exhibit normal epidermis and resultant secreted cuticle, defects lie in internal tissues. Somatic muscle detach and round up. Gut morphogenesis is defective: anterior midgut does not become a slender tube and only two fat gastric caecae are formed. The ventral nerve cord does not fully condense.

Homozygous embryos have an increased rate of axon errors in the central and peripheral nervous systems compared to wild-type.

Small clones (fewer than 150 cells) in the wing are often wild type or have a weak phenotype, even if on the ventral surface. mewH7 ifB2 double mutant small clones display a morphological phenotype.

Mitotic clones in the eye have normal morphology.

Clones in the eye do not exhibit photoreceptor disorganisation.

Extreme defects in somatic muscle attachment sites and morphogenesis of the midgut in the embryo. Muscles pull away from attachment sites at the onset of contractions. Ventral nerve cord fails to shorten completely. There is no dorsal herniation defect. Clonal analysis demonstrated that if function is only required in the cells of the ventral wing surface.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

if[+]/ifB2 is a non-enhancer of visible | dominant phenotype of sogEP7

if[+]/ifB2 is a non-enhancer of visible | dominant phenotype of sogEP11

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

if[+]/ifB2 is a non-suppressor of visible | dominant phenotype of sogEP7

if[+]/ifB2 is a non-suppressor of visible | dominant phenotype of sogEP11

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

ifB2 has muscle attachment site phenotype, enhanceable by Tsp[+]/Tspunspecified

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

if[+]/ifB2 is a non-enhancer of wing vein phenotype of sogEP7

if[+]/ifB2 is a non-enhancer of wing vein phenotype of sogEP11

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

if[+]/ifB2 is a non-suppressor of wing vein phenotype of sogEP7

if[+]/ifB2 is a non-suppressor of wing vein phenotype of sogEP11

Other
Additional Comments
Genetic Interactions
Statement
Reference

Approximately 56% of ifB2/+; p130CAS1/p130CAS1 double mutants emerge as adults.

Approximately 30% of βTub85Dn and ifB2 mutant embryos exhibit salivary gland migration defects.

The mild muscle detachment phenotype of ifB2 mutant embryos is strongly enhanced, both with respect to the extent of detachment and penetrance in embryos that are also heterozygous for Tspunspecified. In these embryos, longitudinal, ventral as well as dorsal muscles are detached, a phenomenon not observed in homozygous Tspunspecified single mutant embryos.

ifB2/Y; TspΔ79 double mutant embryos develop dramatic muscle pattern defects which is beyond an additive effect of the two individual mutant phenotypes.

In combination with either mysolfC-x3, mysolfC-x5, mysolfC-x10 or mysolfC-x17, ifB2 flies show a reduced olfactory response to isoamyl acetate and benzaldehyde. In combination with mysolfC-x5 or mysolfC-x17 (but not mysolfC-x10 or mysolfC-x3), ifB2 flies show a reduced olfactory response to ethyl acetate.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Brabant.

Selected as: F1 screen for mutations that fail to complement if3.

Comments
Comments

Class 0 mutation.

Very little protein made by this allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (20)