FlyBase Allele Report: Dmel\sws[olfE-x26]

General Information

Symbol

Dmel\sws^olfE-x26

Species

D. melanogaster

Name

FlyBase ID

FBal0013252

Feature type

allele

Associated gene

Dmel\sws

Associated Insertion(s)

Carried in Construct

Also Known As

olfE^x26

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ayyub et al., 1990)

Mutagen

ethyl methanesulfonate

(Ayyub et al., 1990)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage

(Jin et al., 2020)

abnormal smell perception

(Ayyub and Paranjape, 2002)

abnormal smell perception | recessive

(Ayyub et al., 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

In the odour-induced jump test, homozygous mutants of sws^olfE-x26 are defective in response to benzaldehyde but not iso-amyl acetate or ethyl acetate, when compared to controls.

(Ayyub and Paranjape, 2002)

Homozygous adults and larvae show a reduced response to benzaldehyde in an olfactory test. Their sensitivity to ethyl acetate, iso-amyl acetate and propionic acid is normal.

(Ayyub et al., 1990)

Larvae and adults show reduction in responses to benzaldehyde in petri-plate-based and Y-tube olfactometric assays, respectively. In odor-induced-jump assay (using benzaldehyde), mutants jump less than half as often as normal flies.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype, suppressible by sws^olfE-E2

(Ayyub and Paranjape, 2002)

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype, suppressible | partially by mys^hs.PBu

(Ayyub and Paranjape, 2002)

Other

Statement

Reference

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

mys^olfC-x5, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

Df(1)C128, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

if^B2, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

if^k27e, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In the odour-induced jump test, mutants with a heteroallelic combination of mys^olfC-x5 or mys^olfC-x17 with sws^olfE-x26 show a reduced response to both iso-amyl acetate and benzaldehyde but a normal response to ethyl acetate, compared to controls. Mutants with the heteroallelic combination of mys^olfC-x3, mys¹⁰ or mys^olfC-x10 with sws^olfE-x26 show normal responses to iso-amyl acetate, ethyl acetate and benzaldehyde compared to controls.

In the odour-induced jump-test, transheterozygous mutants of sws^olfE-x26 and Df(1)C128 are defective in their response to benzaldehyde, but not iso-amyl acetate.

When tested in the odour-induced jump test, mutants with the heteroallelic combination of mys¹⁰ with sws^olfE-x26 show normal responses to iso-amyl acetate, ethyl acetate and benzaldehyde compared to controls.

When tested in the odour-induced jump-test, hemizygous males of sws^olfE-x26 carrying mys^hs.PBu show a reduced response to iso-amyl acetate but not benzaldehyde compared to controls.

When tested in the odour-induced jump-test, double heterozygotes of sws^olfE-x26 with either if^k27e or if^B2 exhibit a reduced response to benzaldehyde, but not to iso-amyl acetate or ethyl acetate, compared to controls.

When tested in the odour-induced jump-test, sws^olfE-E2 rescues the reduced response to iso-amyl acetate and benzaldehyde observed in mys^olfC-x17/sws^olfE-x26 transheterozygotes.

When tested in the odour-induced jump test, mutants with the heteroallelic combination of mys^olfC-x17 and sws^olfE-x26 with mys^hs.PBu show slightly less severely defective responses to iso-amyl acetate and benzaldehyde compared to mys^olfC-x17 and sws^olfE-x26 alone.

(Ayyub and Paranjape, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

sws²

(Kretzschmar et al., 1997)

sws¹

(Kretzschmar et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

1015

sws^olfE-x26

Notes on Origin

Discoverer

Ayyub.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

olfE^X26

(Ayyub and Paranjape, 2002)

olfE^x26

(Ayyub et al., 1990)

sws^olfE-x26

(Jin et al., 2020, Stratoulias and Heino, 2015)

sws^olfE

(Ayyub and Paranjape, 2002)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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