FB2026_02 , released June 18, 2026
Allele: Dmel\swsolfE-E2
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General Information
Symbol
Dmel\swsolfE-E2
Species
D. melanogaster
Name
FlyBase ID
FBal0035310
Feature type
allele
Associated gene
Dmel\sws
Associated Insertion(s)
Carried in Construct
P{Car20-E2}
Key Links
Transgenic product class
genomic_DNA
(Hasan, 1990)
wild_type
(Hasan, 1990)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Hasan, 1990)
wild_type
(Hasan, 1990)
Mutagen
in vitro construct
(Kretzschmar et al., 1997, Hasan, 1990)
Progenitor genotype
Carried in construct
P{Car20-E2}
Cytology
Description

14kb genomic fragment that encompasses the major 5.4kb sws transcript.

(Hasan, 1990)
Allele components
Component
Use(s)
Regulatory region(s)
sws
Encoded product / tool
sws
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      swsolfE-E2 mutants exhibit olfactory behavior defects, as compared to controls.

      (Kretzschmar et al., 1997)

      in the brain. Compact dark bodies are seen in the cortex, especially the lamina cortex. These structures are first seen during late pupal stages, and increase in size during aging of the adult. Approximately 10% of brain cortex neurons are enwrapped by multilayered membranes originating from nearby glia in newly eclosed flies. Membranous whorls are seen in older flies. Homozygotes adults show a significant reduction in lifespan compared to wild-type flies.

      (Kretzschmar et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When tested in the odour-induced jump-test, hemizygous males of mysolfC-x17 carrying swsolfE-E2 show a reduced response to iso-amyl acetate but not benzaldehyde compared to controls.

      When tested in the odour-induced jump-test, swsolfE-E2 suppresses the reduced response to iso-amyl acetate and benzaldehyde observed in mysolfC-x17/swsolfE-x26 transheterozygotes.

      (Ayyub and Paranjape, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      swsolfE-E2 partially rescues swsunspecified

      (Hasan, 1990)
      Comments

      Complemented by either sws1 or sws2.

      (Kretzschmar et al., 1997)

      Partially rescues the sws mutant phenotype as assayed in the olfactory jump assay, and rescues the phenotype as measured in the Y maze test.

      (Hasan, 1990)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      olfEE2
      swsolfE-E2
      Name Synonyms
      Secondary FlyBase IDs
        References (3)