FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(2R)B5
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General Information
Symbol
Df(2R)B5
Species
D. melanogaster
Name
FlyBase ID
FBab0010225
Feature type
chromosomal_deletion
Computed Breakpoints include

46A1-46A4;46C3-46C12

Features within 46A1--46C12
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{wA}l(2)46CbN21
(O'Brien et al., 1994)
Mutagen
X ray
(O'Brien et al., 1994)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Beaton, 1997.3.4, de Nooij et al., 1996, Pauli et al., 1995)
Breakpoints

46A;46C

(de Nooij et al., 1996, Pauli et al., 1995)

46A1-46A4;46C3-46C12

(Beaton, 1997.3.4)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << dap << l(2)46Cd << bk2 << l(2)46Dg

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(O'Brien et al., 1991)
Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0092781) Left limit of break 2 from inclusion of eve (FBrf0074052) Right limit of break 2 from polytene analysis (FBrf0080317)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2R)B5 failed to complement Df(2R)BSC133. Inferred to overlap with: Df(2R)BSC133.

    (Christensen and Cook, 2005.12.14)
    NOT in combination with other aberrations

    Heterozygosity for Df(2R)B5 results in 0.7% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Weak second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance 10-24%.

    (Halsell and Kiehart, 1998)

    dap04454/Df(2R)B5 and dap2X10/Df(2R)B5 hemizygous combination is almost fully lethal.

    (de Nooij et al., 1996)

    Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2R)B5 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)B5 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

    (Mason et al., 2004)

    "46A1--4;46C3--12" was stated as revision.

    (Beaton, 1997.3.4)
    Synonyms and Secondary IDs (2)
    References (37)