FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sec61αEP2567
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General Information
Symbol
Dmel\Sec61αEP2567
Species
D. melanogaster
Name
FlyBase ID
FBal0130604
Feature type
allele
Associated gene
Dmel\Sec61α
Associated Insertion(s)
P{EP}Sec61αEP2567
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kanuka et al., 2003, Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}Sec61αEP2567
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Kanuka et al., 2003)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Transheterozygous combination of Sec61αk04917/Sec61αEP2567 suppresses neurodegenerative disease induced by Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1.

      (Kanuka et al., 2003)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sec61αEP2567 under the control of Scer\GAL4GMR.PF has no affect on the eye.

      (Müller et al., 2005)

      The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

      (Milchanowski et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Sec61αEP2567, Scer\GAL4GMR.PF is an enhancer of visible phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Sec61αEP2567, Scer\GAL4GMR.PF is an enhancer of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EP(2)3567
      (Kanuka et al., 2003)
      Sec61αEP(2)2567
      (Milchanowski et al., 2004)
      Sec61αEP(2)3567
      (Kanuka et al., 2003)
      Sec61αEP2567
      Name Synonyms
      Secondary FlyBase IDs
        References (4)