FlyBase Allele Report: Dmel\aos[rlt]

General Information

Symbol

Dmel\aos^rlt

Species

D. melanogaster

Name

FlyBase ID

FBal0035517

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

Carried in Construct

Also Known As

argos^rlt, rlt¹

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Contains a truncated P-element in the 5' UTR of argos within the proposed transcriptional start at bp 55.

(Gaengel and Mlodzik, 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

abnormal cell polarity (with aos^5F4)

(Strutt and Strutt, 2003)

abnormal cell polarity (with aos^Δ7)

(Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

Phenotype Manifest In

eye

(Choi and Benzer, 1994)

eye photoreceptor cell

(Choi and Benzer, 1994)

eye photoreceptor cell | ectopic

(Strutt and Strutt, 2003)

eye photoreceptor cell | ectopic (with aos^5F4)

(Strutt and Strutt, 2003)

eye photoreceptor cell | ectopic (with aos^Δ7)

(Strutt and Strutt, 2003)

ommatidium

(Fetting et al., 2009, Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

ommatidium (with aos^5F4)

(Strutt and Strutt, 2003)

ommatidium (with aos^Δ7)

(Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

Detailed Description

Statement

Reference

Many argos^rlt ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes and the mean angle of orientation of the ommatidia is only 77.84[o] (compared to 90[o] in wild type).

(Fetting et al., 2009)

Homozygotes, argos^rlt/argos^Δ7 or argos^rlt/Df(3L)st7P animals exhibit a ommatidial rotation phenotype. Clusters are seen that are both over and under-rotated with respect to their neighbours and developmental stage. Mutant animals do not exhibit any photoreceptor R3/R4 cell fate defects.

(Gaengel and Mlodzik, 2003)

About 12% of ommatidia in homozygous argos^rlt animals exhibit extra R cells. Of those that ommatidia that remain about 49% exhibit misrotations, about 6% exhibit achirality, and about 1% exhibit the wrong chirality. About 11% of ommatidia in argos^Δ7/argos^rlt animals exhibit extra R cells. Of those that ommatidia that remain about 52% exhibit misrotations, about 1% exhibit achirality, and about 1% exhibit the wrong chirality. About 16% of ommatidia in argos^5F4/argos^rlt animals exhibit extra R cells. Of those that ommatidia that remain about 53% exhibit misrotations, about 2% exhibit achirality, and about 0.3% exhibit the wrong chirality.

(Strutt and Strutt, 2003)

The addition of argos^rlt/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals.

(Strutt and Strutt, 2003)

Photoreceptor orientation is abnormal. The majority of ommatidia have the normal number of photoreceptors, in normal trapezoidal configuration, though 17% of ommatidia have an extra photoreceptor cell. But 47% of photoreceptor clusters actually rotate more than 90^o. nmo mutants are epistatic to argos^rlt with respect to ommatidial precluster orientation.

(Choi and Benzer, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

aos^rlt has abnormal cell polarity phenotype, suppressible by Egfr^t1

(Gaengel and Mlodzik, 2003)

aos^rlt has abnormal cell polarity phenotype, suppressible by Ras85D^e2F

(Gaengel and Mlodzik, 2003)

aos^rlt has abnormal cell polarity phenotype, suppressible by nmo^P1

(Gaengel and Mlodzik, 2003)

aos^rlt has abnormal cell polarity phenotype, suppressible by pnt^Δ88

(Gaengel and Mlodzik, 2003)

Enhancer of

Statement

Reference

aos[+]/aos^rlt is an enhancer of visible phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

aos[+]/aos^rlt is an enhancer of abnormal planar polarity phenotype of Mtl^UAS.cMa, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

aos^rlt is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

NOT Enhancer of

Statement

Reference

argos[+]/aos^rlt is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

aos^rlt is a suppressor of abnormal cell polarity phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

NOT Suppressor of

Statement

Reference

argos[+]/aos^rlt is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

aos^rlt has ommatidium phenotype, suppressible by Egfr^t1

(Gaengel and Mlodzik, 2003)

aos^rlt has ommatidium phenotype, suppressible by Ras85D^e2F

(Gaengel and Mlodzik, 2003)

aos^rlt has ommatidium phenotype, suppressible by nmo^P1

(Gaengel and Mlodzik, 2003)

aos^rlt has ommatidium phenotype, suppressible by pnt^Δ88

(Gaengel and Mlodzik, 2003)

Enhancer of

Statement

Reference

aos[+]/aos^rlt is an enhancer of wing vein phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

aos[+]/aos^rlt is an enhancer of ommatidium phenotype of Mtl^UAS.cMa, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

aos^rlt is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

NOT Enhancer of

Statement

Reference

argos[+]/aos^rlt is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

argos[+]/aos^rlt is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2008)

aos^rlt is a suppressor of ommatidium phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

aos^rlt is a suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

NOT Suppressor of

Statement

Reference

argos[+]/aos^rlt is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

argos[+]/aos^rlt is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Fiehler and Wolff, 2008)

aos^rlt is a non-suppressor of ommatidium phenotype of ec^spok

(Montrasio et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The small-eye phenotype observed in animals expressing H^Scer\UAS.cMa in the eye under the control of Scer\GAL4^GMR.PU is partially suppressed in a argos^rlt/+ mutant background.

(Protzer et al., 2008)

The ommatidial rotation defects observed in ec^spok hemizygous adult eyes are not suppressed by argos^rlt/+.

(Montrasio et al., 2007)

S^48-5/argos^rlt mutants show 3.74%+-1.99 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

Heterozygotes suppress the ommatidial polarity defects seen in Ras64B^V14.Act5C.

(Strutt and Strutt, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

aos^rlt is rescued by aos^sev.PF

(Gaengel and Mlodzik, 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7336

aos^rlt

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

aos^rlt1

(Montrasio et al., 2007)

aos^rlt

(Valentine et al., 2014, Fetting et al., 2009, Muñoz-Descalzo et al., 2007)

argos^rlt

(Duan et al., 2018, Harris et al., 2011, Djiane and Mlodzik, 2010, Fiehler and Wolff, 2008, Protzer et al., 2008)

rlt¹

(Brown and Freeman, 2003, Gaengel and Mlodzik, 2003, Fanto, 2000, Fanto et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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