FlyBase Allele Report: Dmel\Dsp1[EP355]

General Information

Symbol

Dmel\Dsp1^EP355

Species

D. melanogaster

Name

FlyBase ID

FBal0089430

Feature type

allele

Associated gene

Dmel\Dsp1

Associated Insertion(s)

P{EP}Dsp1^EP355

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Rorth et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{EP}Dsp1^EP355

Cytology

Description

The P{EP} element is inserted within the 5' UTR.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:16,333,634..16,333,634 [+]

(Cao et al., 2008, Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Rorth et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^GMR.PF

(Müller et al., 2005)

Phenotype Manifest In

adult thorax | dorsal, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

eye, with Scer\GAL4^GMR.PF

(Müller et al., 2005)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

scutellum, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

wing, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Expression using Scer\GAL4^ey.PU does not induce a rough eye phenotype.

(Cao et al., 2008)

Mutant flies show a higher bacterial clearance activity than do control flies after injection with E.coli.

Mutant flies show a lower survival rate after infection with E.coli than do control flies.

(Kim et al., 2007)

Expression of Dsp1^EP355 under the control of Scer\GAL4^GMR.PF results in a weak rough eye phenotype.

(Müller et al., 2005)

Flies expressing Dsp1^EP355 under the control of Scer\GAL4^ap-md544 have a strong thoracic cleft and a deformed scutellum and wings.

(Pena-Rangel et al., 2002)

Mutant larvae expressing Dsp1^EP355 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. Mutant larvae expressing Dsp1^EP355 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dsp1^EP355, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Dsp1^EP355/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237