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General Information
Symbol
Dmel\icsBG02577
Species
D. melanogaster
Name
FlyBase ID
FBal0137650
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the first exon of ics that disrupts the coding sequence.

Insertion components
P{GT1}icsBG02577
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

icsBG02577/icsBG02577 flies are more resistant to ethanol-induced sedation than icsBG02577/+ or wild type flies, but have normal ethanol absorption and metabolism and show normal locomotion.

icsBG02577 homozygotes display wing blisters at 60% penetrance.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

icsBG02577 has no effect on the viability of flies expressing stckwt.T:Zzzz\FLAG in a stck3R-17/stck18 mutant background.

The addition of icsBG02577 reduces the viability of flies expressing stckQ38A.T:Zzzz\FLAG in a stck3R-17/stck18 mutant background. Between 6 and 34% of the expected number of progeny are seen, with the majority of the lethality taking place during the larval and pharate stages. The rescued larvae display a range of sizes, including presumptive first instar larvae that appear stumpy, exhibit sluggish movement and do not progress in development.

Homozygosity for icsBG02577 suppresses the msn102 'dorsal open' phenotype, reducing its incidence from approximately 30% to approximately 2%.

Homozygosity for icsBG02577 increases the incidence of eclosion seen in msn03349 homozygotes from approximately 0.5% to approximately 3%, and completely suppresses the msn03349 thorax closure defects.

Homozygosity for icsBG02577 suppresses the bsk1 'dorsal open' phenotype, reducing its incidence from approximately 60% to approximately 30%.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
BG:BACR48E02.4BG02577
CG9031BG02577
Rsu-1BG02577
icsBG02577
Name Synonyms
Secondary FlyBase IDs
    References (4)